Author results

1JM4
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NMR STRUCTURE OF P/CAF BROMODOMAIN IN COMPLEX WITH HIV-1 TAT PEPTIDE
Descriptor:HIV-1 Tat Peptide, P300/CBP-associated Factor
Authors:Mujtaba, S., He, Y., Zeng, L., Farooq, A., Carlson, J.E., Ott, M., Verdin, E., Zhou, M.-M.
Deposit date:2001-07-17
Release date:2002-07-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain
Mol.Cell, 9, 2002
1M3G
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SOLUTION STRUCTURE OF THE CATALYTIC DOMAIN OF MAPK PHOSPHATASE PAC-1: INSIGHTS INTO SUBSTRATE-INDUCED ENZYMATIC ACTIVATION
Descriptor:DUAL SPECIFICITY PROTEIN PHOSPHATASE 2
Authors:Farooq, A., Zhou, M.-M.
Deposit date:2002-06-27
Release date:2003-06-27
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution Structure of the MAPK Phosphatase PAC-1 Catalytic Domain Insights into Substrate-Induced Enzymatic Activation of MKP
Structure, 11, 2003
1N3H
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COUPLING OF FOLDING AND BINDING IN THE PTB DOMAIN OF THE SIGNALING PROTEIN SHC
Descriptor:SHC Transforming protein
Authors:Farooq, A., Zeng, L., Yan, K.S., Ravichandran, K.S., Zhou, M.-M.
Deposit date:2002-10-28
Release date:2003-10-28
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Coupling of Folding and Binding in the PTB Domain of the Signaling Protein Shc
Structure, 11, 2003
1N3J
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STRUCTURE AND SUBSTRATE OF A HISTONE H3 LYSINE METHYLTRANSFERASE FROM PARAMECIUM BURSARIA CHLORELLA VIRUS 1
Descriptor:Histone H3 Lysine Methyltransferase
Authors:Manzur, K.L., Farooq, A., Zeng, L., Plotnikova, O., Sachchidanand, Koch, A.W., Zhou, M.-M.
Deposit date:2002-10-28
Release date:2003-01-28
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A dimeric viral SET domain methyltransferase specific to Lys27 of histone H3.
Nat.Struct.Biol., 10, 2003
1N72
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STRUCTURE AND LIGAND OF A HISTONE ACETYLTRANSFERASE BROMODOMAIN
Descriptor:HISTONE ACETYLTRANSFERASE
Authors:Dhalluin, C., Carlson, J.E., Zeng, L., He, C., Aggarwal, A.K., Zhou, M.-M.
Deposit date:2002-11-12
Release date:2002-12-11
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure and Ligand of a Histone Acetyltransferase Bromodomain
Nature, 399, 1999
1OP4
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SOLUTION STRUCTURE OF NEURAL CADHERIN PRODOMAIN
Descriptor:Neural-cadherin
Authors:Koch, A.W., Farooq, A., Shan, W., Zeng, L., Colman, D.R., Zhou, M.-M.
Deposit date:2003-03-04
Release date:2004-03-16
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of the Neural (N-) Cadherin Prodomain Reveals a Cadherin Extracellular Domain-like Fold without Adhesive Characteristics
Structure, 12, 2004
1OY2
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COUPLING OF FOLDING AND BINDING IN THE PTB DOMAIN OF THE SIGNALING PROTEIN SHC
Descriptor:SHC transforming protein
Authors:Farooq, A., Zeng, L., Yan, K.S., Ravichandran, K.S., Zhou, M.-M.
Deposit date:2003-04-03
Release date:2004-04-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Coupling of Folding and Binding in the PTB Domain of the Signaling Protein Shc
Structure, 11, 2003
1R4K
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SOLUTION STRUCTURE OF THE DROSOPHILA ARGONAUTE 1 PAZ DOMAIN
Descriptor:Argonaute 1
Authors:Yan, K.S., Yan, S., Farooq, A., Han, A., Zeng, L., Zhou, M.-M.
Deposit date:2003-10-07
Release date:2003-12-09
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure and conserved RNA binding of the PAZ domain
Nature, 426, 2003
1XR0
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STRUCTURAL BASIS OF SNT PTB DOMAIN INTERACTIONS WITH DISTINCT NEUROTROPHIC RECEPTORS
Descriptor:Basic fibroblast growth factor receptor 1, FGFR signalling adaptor SNT-1
Authors:Dhalluin, C., Yan, K.S., Plotnikova, O., Lee, K.W., Zeng, L., Kuti, M., Mujtaba, S., Goldfarb, M.P., Zhou, M.-M.
Deposit date:2004-10-13
Release date:2004-11-02
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural Basis of SNT PTB Domain Interactions with Distinct Neurotrophic Receptors
Mol.Cell, 6, 2000
2AQE
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STRUCTURAL AND FUNCTIONAL ANALYSIS OF ADA2 ALPHA SWIRM DOMAIN
Descriptor:Transcriptional adaptor 2, Ada2 alpha
Authors:Qian, C., Zhang, Q., Zeng, L., Zhou, M.-M.
Deposit date:2005-08-17
Release date:2005-12-13
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure and chromosomal DNA binding of the SWIRM domain
Nat.Struct.Mol.Biol., 12, 2005
4NUC
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CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH MS435 INHIBITOR
Descriptor:Bromodomain-containing protein 4, 4-[(E)-(4-hydroxy-3,5-dimethylphenyl)diazenyl]-N-(pyridin-2-yl)benzenesulfonamide, 1,2-ETHANEDIOL
Authors:Plotnikov, A.N., Joshua, J., Zhou, M.-M.
Deposit date:2013-12-03
Release date:2014-04-02
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure-Guided Design of Potent Diazobenzene Inhibitors for the BET Bromodomains
J.Med.Chem., 56, 2013
4NUD
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CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH MS436 INHIBITOR
Descriptor:Bromodomain-containing protein 4, 4-[(E)-(2-amino-4-hydroxy-5-methylphenyl)diazenyl]-N-(pyridin-2-yl)benzenesulfonamide, 1,2-ETHANEDIOL
Authors:Plotnikov, A.N., Joshua, J., Zhou, M.-M.
Deposit date:2013-12-03
Release date:2014-04-02
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structure-Guided Design of Potent Diazobenzene Inhibitors for the BET Bromodomains
J.Med.Chem., 56, 2013
4NUE
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CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH MS267 INHIBITOR
Descriptor:Bromodomain-containing protein 4, 4-[(E)-(2-amino-4-hydroxy-3,5-dimethylphenyl)diazenyl]-N-(pyridin-2-yl)benzenesulfonamide, 1,2-ETHANEDIOL
Authors:Plotnikov, A.N., Joshua, J., Zhou, M.-M.
Deposit date:2013-12-03
Release date:2014-04-02
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structure-Guided Design of Potent Diazobenzene Inhibitors for the BET Bromodomains
J.Med.Chem., 56, 2013
1BVH
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SOLUTION STRUCTURE OF A LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE
Descriptor:ACID PHOSPHATASE
Authors:Logan, T.M., Zhou, M.-M., Nettesheim, D.G., Meadows, R.P., Van Etten, R.L., Fesik, S.W.
Deposit date:1994-05-03
Release date:1994-07-31
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of a low molecular weight protein tyrosine phosphatase.
Biochemistry, 33, 1994
1IRS
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IRS-1 PTB DOMAIN COMPLEXED WITH A IL-4 RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE
Descriptor:IRS-1, IL-4 RECEPTOR PHOSPHOPEPTIDE
Authors:Zhou, M.-M., Huang, B., Olejniczak, E.T., Meadows, R.P., Shuker, S.B., Miyazaki, M., Trub, T., Shoelson, S.E., Feisk, S.W.
Deposit date:1996-03-22
Release date:1997-05-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural basis for IL-4 receptor phosphopeptide recognition by the IRS-1 PTB domain.
Nat.Struct.Biol., 3, 1996
1SHC
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SHC PTB DOMAIN COMPLEXED WITH A TRKA RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE
Descriptor:SHC, TRKA RECEPTOR PHOSPHOPEPTIDE
Authors:Zhou, M.-M., Ravichandran, K.S., Olejniczak, E.T., Petros, A.M., Meadows, R.P., Sattler, M., Harlan, J.E., Wade, W.S., Burakoff, S.J., Fesik, S.W.
Deposit date:1996-03-27
Release date:1997-05-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure and ligand recognition of the phosphotyrosine binding domain of Shc.
Nature, 378, 1995
1TCE
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SOLUTION NMR STRUCTURE OF THE SHC SH2 DOMAIN COMPLEXED WITH A TYROSINE-PHOSPHORYLATED PEPTIDE FROM THE T-CELL RECEPTOR, MINIMIZED AVERAGE STRUCTURE
Descriptor:SHC, PHOSPHOPEPTIDE OF THE ZETA CHAIN OF T CELL RECEPTOR
Authors:Zhou, M.-M., Meadows, R.P., Logan, T.M., Yoon, H.S., Wade, W.R., Ravichandran, K.S., Burakoff, S.J., Feisk, S.W.
Deposit date:1996-03-27
Release date:1997-05-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the Shc SH2 domain complexed with a tyrosine-phosphorylated peptide from the T-cell receptor.
Proc.Natl.Acad.Sci.USA, 92, 1995
4N4F
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CRYSTAL STRUCTURE OF THE BROMODOMAIN-PHD FINGER MODULE OF HUMAN TRANSCRIPTIONAL CO-ACTIVATOR CBP IN COMPLEX WITH DI-ACETYLATED HISTONE 4 PEPTIDE (H412ACK16AC).
Descriptor:CREB-binding protein, Histone 4 Peptide, ZINC ION
Authors:Plotnikov, A.N., Zhou, J., Zhou, M.-M.
Deposit date:2013-10-08
Release date:2014-02-19
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Structural Insights into Acetylated-Histone H4 Recognition by the Bromodomain-PHD Finger Module of Human Transcriptional Coactivator CBP.
Structure, 22, 2014
4N3W
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CRYSTAL STRUCTURE OF THE BROMODOMAIN-PHD FINGER MODULE OF HUMAN TRANSCRIPTIONAL CO-ACTIVATOR CBP IN COMPLEX WITH ACETYLATED HISTONE 4 PEPTIDE (H4K20AC).
Descriptor:CREB-binding protein, Histone H4 peptide, ZINC ION
Authors:Plotnikov, A.N., Yang, S., Zhou, M.-M.
Deposit date:2013-10-07
Release date:2014-01-29
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Insights into Acetylated-Histone H4 Recognition by the Bromodomain-PHD Finger Module of Human Transcriptional Coactivator CBP.
Structure, 22, 2014
5ULA
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CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH CYCLIC VINYLOGOUS AMIDE INHIBITOR MS402
Descriptor:Bromodomain-containing protein 4, 3-chloranyl-~{N}-(4-methoxyphenyl)-4-[(2-methyl-3-oxidanylidene-cyclopenten-1-yl)amino]benzamide
Authors:Plotnikov, A.N., Joshua, j., Zhou, M.-M.
Deposit date:2017-01-24
Release date:2017-03-22
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:BET N-terminal bromodomain inhibition selectively blocks Th17 cell differentiation and ameliorates colitis in mice.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
6MNL
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NMR SOLUTION STRUCTURES OF SECOND BROMODOMAIN OF BRD4 WITH FOXO3A PEPTIDE
Descriptor:FOXO3a peptide, Bromodomain-containing protein 4
Authors:Zeng, L., Zhou, M.-M.
Deposit date:2018-10-02
Release date:2018-10-31
Last modified:2018-12-19
Method:SOLUTION NMR
Cite:Targeting the BRD4/FOXO3a/CDK6 axis sensitizes AKT inhibition in luminal breast cancer.
Nat Commun, 9, 2018
1HZM
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STRUCTURE OF ERK2 BINDING DOMAIN OF MAPK PHOSPHATASE MKP-3: STRUCTURAL INSIGHTS INTO MKP-3 ACTIVATION BY ERK2
Descriptor:DUAL SPECIFICITY PROTEIN PHOSPHATASE 6
Authors:Farooq, A., Zhou, M.-M.
Deposit date:2001-01-25
Release date:2002-01-25
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of ERK2 binding domain of MAPK phosphatase MKP-3: structural insights into MKP-3 activation by ERK2.
Mol.Cell, 7, 2001
1JSP
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NMR STRUCTURE OF CBP BROMODOMAIN IN COMPLEX WITH P53 PEPTIDE
Descriptor:tumor protein p53, CREB-BINDING PROTEIN
Authors:He, Y., Mujtaba, S., Zeng, L., Yan, S., Zhou, M.-M.
Deposit date:2001-08-17
Release date:2002-08-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.
Mol.Cell, 13, 2004
2AQF
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STRUCTURAL AND FUNCTIONAL ANALYSIS OF ADA2 ALPHA SWIRM DOMAIN
Descriptor:transcriptional adaptor 2, Ada2 alpha
Authors:Qian, C., Zhang, Q., Zhou, M.-M., Zeng, L.
Deposit date:2005-08-17
Release date:2006-01-31
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure and chromosomal DNA binding of the SWIRM domain.
Nat.Struct.Mol.Biol., 12, 2005
2LSP
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SOLUTION STRUCTURES OF BRD4 SECOND BROMODOMAIN WITH NF-KB-K310AC PEPTIDE
Descriptor:NF-kB-K310ac peptide, Bromodomain-containing protein 4
Authors:Zhang, G., Liu, R., Zhong, Y., Plotnikov, A.N., Zhang, W., Rusinova, E., Gerona-Nevarro, G., Moshkina, N., Joshua, J., Chuang, P.Y., Ohlmeyer, M., He, J., Zhou, M.-M.
Deposit date:2012-05-03
Release date:2012-07-18
Last modified:2013-08-28
Method:SOLUTION NMR
Cite:Down-regulation of NF-kappa B transcriptional activity in HIV-associated kidney disease by BRD4 inhibition.
J.Biol.Chem., 287, 2012
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