1SHC

SHC PTB DOMAIN COMPLEXED WITH A TRKA RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE

Summary for 1SHC

DescriptorSHC, TRKA RECEPTOR PHOSPHOPEPTIDE (2 entities in total)
Functional Keywordscomplex (signal transduction-peptide), phosphotyrosine binding domain (ptb), complex (signal transduction-peptide) complex, complex (signal transduction/peptide)
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm. Isoform p46Shc: Mitochondrion matrix. Isoform p66Shc: Mitochondrion (By similarity) P29353
Cell membrane; Single-pass type I membrane protein (By similarity) P04629
Total number of polymer chains2
Total molecular weight22924.09
Authors
Zhou, M.-M.,Ravichandran, K.S.,Olejniczak, E.T.,Petros, A.M.,Meadows, R.P.,Sattler, M.,Harlan, J.E.,Wade, W.S.,Burakoff, S.J.,Fesik, S.W. (deposition date: 1996-03-27, release date: 1997-05-15, Last modification date: 2011-07-13)
Primary citation
Zhou, M.M.,Ravichandran, K.S.,Olejniczak, E.F.,Petros, A.M.,Meadows, R.P.,Sattler, M.,Harlan, J.E.,Wade, W.S.,Burakoff, S.J.,Fesik, S.W.
Structure and ligand recognition of the phosphotyrosine binding domain of Shc.
Nature, 378:584-592, 1995
PubMed: 8524391 (PDB entries with the same primary citation)
DOI: 10.1038/378584a0
MImport into Mendeley
Experimental method
SOLUTION NMR
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Structure validation

ClashscoreRamachandran outliersSidechain outliers36 13.4% 39.5%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures
Download full validation reportDownload
171916
PDB entries from 2020-12-02