2LSP

solution structures of BRD4 second bromodomain with NF-kB-K310ac peptide

Summary for 2LSP

• Entry DOI: 10.2210/pdb2lsp/pdb
• NMR Information: BMRB: 18439
• Descriptor: NF-kB-K310ac peptide, Bromodomain-containing protein 4 (2 entities in total)
• Functional Keywords: nf-kb, brd4, hiv, bromodomain, kidney disease, protein binding
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: Q04206 O60885
• Total number of polymer chains: 2
• Total formula weight: 16506.01

Authors

Zhang, G.,Liu, R.,Zhong, Y.,Plotnikov, A.N.,Zhang, W.,Rusinova, E.,Gerona-Nevarro, G.,Moshkina, N.,Joshua, J.,Chuang, P.Y.,Ohlmeyer, M.,He, J.,Zhou, M.-M. (deposition date: 2012-05-03, release date: 2012-07-18, Last modification date: 2023-11-15)

• Primary citation: Zhang, G.,Liu, R.,Zhong, Y.,Plotnikov, A.N.,Zhang, W.,Zeng, L.,Rusinova, E.,Gerona-Nevarro, G.,Moshkina, N.,Joshua, J.,Chuang, P.Y.,Ohlmeyer, M.,He, J.C.,Zhou, M.M.; Down-regulation of NF-kappa B transcriptional activity in HIV-associated kidney disease by BRD4 inhibition.; J.Biol.Chem., 287:28840-28851, 2012; PubMed: 22645123; DOI: 10.1074/jbc.M112.359505

Experimental method

SOLUTION NMR