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4QB3

Crystal structure of the first bromodomain of human BRD4 in complex with Olinone

Summary for 4QB3
Entry DOI10.2210/pdb4qb3/pdb
DescriptorBromodomain-containing protein 4, N-[4-(1-oxo-1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indol-5-yl)butyl]acetamide, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordsbromodomain, transcription factor, acetyl-lysine binding, transcription-transcription inhibitor complex, transcription/transcription inhibitor
Biological sourceHomo sapiens (human)
Cellular locationNucleus: O60885
Total number of polymer chains1
Total formula weight15460.82
Authors
Plotnikov, A.N.,Joshua, J.,Zhou, M.-M. (deposition date: 2014-05-06, release date: 2015-04-22, Last modification date: 2023-09-20)
Primary citationGacias, M.,Gerona-Navarro, G.,Plotnikov, A.N.,Zhang, G.,Zeng, L.,Kaur, J.,Moy, G.,Rusinova, E.,Rodriguez, Y.,Matikainen, B.,Vincek, A.,Joshua, J.,Casaccia, P.,Zhou, M.M.
Selective chemical modulation of gene transcription favors oligodendrocyte lineage progression.
Chem.Biol., 21:841-854, 2014
Cited by
PubMed: 24954007
DOI: 10.1016/j.chembiol.2014.05.009
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (0.94 Å)
Structure validation

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