1IRS

IRS-1 PTB DOMAIN COMPLEXED WITH A IL-4 RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE

Summary for 1IRS

DescriptorIRS-1, IL-4 RECEPTOR PHOSPHOPEPTIDE (2 entities in total)
Functional Keywordsphosphotyrosine binding domain (ptb), complex, signal transduction, complex (signal transduction-peptide), complex (signal transduction-peptide) complex, complex (signal transduction/peptide)
Biological sourceHomo sapiens (human)
Cellular locationCell membrane; Single-pass type I membrane protein. Isoform 2: Secreted P24394
Total number of polymer chains2
Total molecular weight13890.05
Authors
Zhou, M.-M.,Huang, B.,Olejniczak, E.T.,Meadows, R.P.,Shuker, S.B.,Miyazaki, M.,Trub, T.,Shoelson, S.E.,Feisk, S.W. (deposition date: 1996-03-22, release date: 1997-05-15, Last modification date: 2011-07-13)
Primary citation
Zhou, M.M.,Huang, B.,Olejniczak, E.T.,Meadows, R.P.,Shuker, S.B.,Miyazaki, M.,Trub, T.,Shoelson, S.E.,Fesik, S.W.
Structural basis for IL-4 receptor phosphopeptide recognition by the IRS-1 PTB domain.
Nat.Struct.Biol., 3:388-393, 1996
PubMed: 8599766 (PDB entries with the same primary citation)
DOI: 10.1038/nsb0496-388
MImport into Mendeley
Experimental method
SOLUTION NMR
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliers155.1%25.2%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures

More Asymmetric unit images

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