4NUD

Crystal structure of the first bromodomain of human BRD4 in complex with MS436 inhibitor

Summary for 4NUD

Entry DOI	10.2210/pdb4nud/pdb
Related	4NUC 4NUE
Descriptor	Bromodomain-containing protein 4, 4-[(E)-(2-amino-4-hydroxy-5-methylphenyl)diazenyl]-N-(pyridin-2-yl)benzenesulfonamide, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	transcription factor, transcription, transcription-transcription inhibitor complex, transcription/transcription inhibitor
Biological source	Homo sapiens (human)
Cellular location	Nucleus: O60885
Total number of polymer chains	1
Total formula weight	15544.87
Authors	Plotnikov, A.N.,Joshua, J.,Zhou, M.-M. (deposition date: 2013-12-03, release date: 2014-04-02, Last modification date: 2024-02-28)
Primary citation	Zhang, G.,Plotnikov, A.N.,Rusinova, E.,Shen, T.,Morohashi, K.,Joshua, J.,Zeng, L.,Mujtaba, S.,Ohlmeyer, M.,Zhou, M.-M. Structure-Guided Design of Potent Diazobenzene Inhibitors for the BET Bromodomains J.Med.Chem., 56:9251-9264, 2013 Cited by PubMed: 24144283 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.2 Å)

Structure validation