Author results

6XC2
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CRYSTAL STRUCTURE OF SARS-COV-2 RECEPTOR BINDING DOMAIN IN COMPLEX WITH NEUTRALIZING ANTIBODY CC12.1
Descriptor:Spike protein S1, CC12.1 light chain, CC12.1 heavy chain, ...
Authors:Yuan, M., Liu, H., Wu, N.C., Zhu, X., Wilson, I.A.
Deposit date:2020-06-08
Release date:2020-07-08
Last modified:2020-09-16
Method:X-RAY DIFFRACTION (3.112 Å)
Cite:Structural basis of a shared antibody response to SARS-CoV-2.
Science, 369, 2020
6XC3
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CRYSTAL STRUCTURE OF SARS-COV-2 RECEPTOR BINDING DOMAIN IN COMPLEX WITH ANTIBODIES CC12.1 AND CR3022
Descriptor:CR3022 heavy chain, CR3022 light chain, CC12.1 light chain, ...
Authors:Yuan, M., Liu, H., Wu, N.C., Zhu, X., Wilson, I.A.
Deposit date:2020-06-08
Release date:2020-07-08
Last modified:2020-09-16
Method:X-RAY DIFFRACTION (2.698 Å)
Cite:Structural basis of a shared antibody response to SARS-CoV-2.
Science, 369, 2020
6XC4
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CRYSTAL STRUCTURE OF SARS-COV-2 RECEPTOR BINDING DOMAIN IN COMPLEX WITH NEUTRALIZING ANTIBODY CC12.3
Descriptor:Spike protein S1, CC12.3 heavy chain, CC12.3 light chain, ...
Authors:Yuan, M., Liu, H., Wu, N.C., Zhu, X., Wilson, I.A.
Deposit date:2020-06-08
Release date:2020-07-08
Last modified:2020-09-16
Method:X-RAY DIFFRACTION (2.341 Å)
Cite:Structural basis of a shared antibody response to SARS-CoV-2.
Science, 369, 2020
6XC7
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CRYSTAL STRUCTURE OF SARS-COV-2 RECEPTOR BINDING DOMAIN IN COMPLEX WITH ANTIBODIES CC12.3 AND CR3022
Descriptor:Spike protein S1, CR3022 heavy chain, CR3022 light chain, ...
Authors:Yuan, M., Liu, H., Wu, N.C., Zhu, X., Wilson, I.A.
Deposit date:2020-06-08
Release date:2020-07-08
Last modified:2020-09-16
Method:X-RAY DIFFRACTION (2.883 Å)
Cite:Structural basis of a shared antibody response to SARS-CoV-2.
Science, 369, 2020
5OEY
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CRYSTAL STRUCTURE OF LEISHMANIA MAJOR FRUCTOSE-1,6-BISPHOSPHATASE IN HOLO FORM.
Descriptor:FBP protein, PHOSPHATE ION, MANGANESE (II) ION, ...
Authors:Yuan, M., Vasquez-Valdivieso, M.G., McNae, I.W., Michels, P.A.M., Fothergill-Gilmore, L.A., Walkinshaw, M.D.
Deposit date:2017-07-10
Release date:2017-09-20
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structures of Leishmania Fructose-1,6-Bisphosphatase Reveal Species-Specific Differences in the Mechanism of Allosteric Inhibition.
J. Mol. Biol., 429, 2017
5OEZ
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CRYSTAL STRUCTURE OF LEISHMANIA MAJOR FRUCTOSE-1,6-BISPHOSPHATASE IN APO FORM.
Descriptor:FBP protein
Authors:Yuan, M., Vasquez-Valdivieso, M.G., McNae, I.W., Michels, P.A.M., Fothergill-Gilmore, L.A., Walkinshaw, M.D.
Deposit date:2017-07-10
Release date:2017-09-20
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Structures of Leishmania Fructose-1,6-Bisphosphatase Reveal Species-Specific Differences in the Mechanism of Allosteric Inhibition.
J. Mol. Biol., 429, 2017
5OFU
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CRYSTAL STRUCTURE OF LEISHMANIA MAJOR FRUCTOSE-1,6-BISPHOSPHATASE IN T-STATE.
Descriptor:FBP protein, ADENOSINE MONOPHOSPHATE, 6-O-phosphono-beta-D-fructofuranose, ...
Authors:Yuan, M., Vasquez-Valdivieso, M.G., McNae, I.W., Michels, P.A.M., Fothergill-Gilmore, L.A., Walkinshaw, M.D.
Deposit date:2017-07-11
Release date:2017-09-20
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Structures of Leishmania Fructose-1,6-Bisphosphatase Reveal Species-Specific Differences in the Mechanism of Allosteric Inhibition.
J. Mol. Biol., 429, 2017
6NCP
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CRYSTAL STRUCTURE OF HIV-1 BROADLY NEUTRALIZING ANTIBODY ACS202
Descriptor:ACS202 Fab heavy chain, ACS202 Fab light chain, HIV-1 Fusion Peptide (residues 512-520), ...
Authors:Yuan, M., Wilson, I.A.
Deposit date:2018-12-11
Release date:2019-06-19
Last modified:2019-11-13
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Conformational Plasticity in the HIV-1 Fusion Peptide Facilitates Recognition by Broadly Neutralizing Antibodies.
Cell Host Microbe, 25, 2019
6W41
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CRYSTAL STRUCTURE OF SARS-COV-2 RECEPTOR BINDING DOMAIN IN COMPLEX WITH HUMAN ANTIBODY CR3022
Descriptor:CR3022 Fab heavy chain, CR3022 Fab light chain, Spike protein S1, ...
Authors:Yuan, M., Wu, N.C., Zhu, X.Y., Wilson, I.A.
Deposit date:2020-03-09
Release date:2020-03-25
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.084 Å)
Cite:A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV.
Science, 368, 2020
6VOR
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CRYSTAL STRUCTURE OF MACAQUE ANTI-HIV-1 ANTIBODY RM20E1
Descriptor:RM20E1 Fab heavy chain, RM20E1 Fab light chain, GLYCINE
Authors:Yuan, M., Wilson, I.A.
Deposit date:2020-01-31
Release date:2020-09-16
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates.
Plos Pathog., 16, 2020
6VOS
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CRYSTAL STRUCTURE OF MACAQUE ANTI-HIV-1 ANTIBODY RM20J
Descriptor:RM20J Fab heavy chain, RM20J Fab light chain, TRIS(HYDROXYETHYL)AMINOMETHANE, ...
Authors:Yuan, M., Wilson, I.A.
Deposit date:2020-01-31
Release date:2020-09-16
Method:X-RAY DIFFRACTION (2.299 Å)
Cite:Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates.
Plos Pathog., 16, 2020
6XKQ
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CRYSTAL STRUCTURE OF SARS-COV-2 RECEPTOR BINDING DOMAIN IN COMPLEX WITH NEUTRALIZING ANTIBODY CV07-250
Descriptor:Spike protein S1, CV07-250 Heavy Chain, CV07-250 Light Chain, ...
Authors:Yuan, M., Liu, H., Zhu, X., Wu, N.C., Wilson, I.A.
Deposit date:2020-06-26
Release date:2020-10-14
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:A therapeutic non-self-reactive SARS-CoV-2 antibody protects from lung pathology in a COVID-19 hamster model
Cell(Cambridge,Mass.), 2020
6GG3
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CRYSTAL STRUCTURE OF M2 PYK IN COMPLEX WITH ALANINE.
Descriptor:Pyruvate kinase PKM, PHOSPHATE ION, ALANINE
Authors:McNae, I.W., Yuan, M., Walkinshaw, M.D.
Deposit date:2018-05-02
Release date:2019-09-04
Method:X-RAY DIFFRACTION (3.72 Å)
Cite:An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor.
Biochem.J., 475, 2018
6GG4
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CRYSTAL STRUCTURE OF M2 PYK IN COMPLEX WITH PHENYALANINE.
Descriptor:Pyruvate kinase PKM, PHOSPHATE ION, PHENYLALANINE, ...
Authors:McNae, I.W., Yuan, M., Walkinshaw, M.D.
Deposit date:2018-05-02
Release date:2018-05-23
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor.
Biochem. J., 475, 2018
6GG5
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CRYSTAL STRUCTURE OF M2 PYK IN COMPLEX WITH TRYPTOPHAN.
Descriptor:Pyruvate kinase PKM, PHOSPHATE ION, TRYPTOPHAN, ...
Authors:McNae, I.W., Yuan, M., Walkinshaw, M.D.
Deposit date:2018-05-02
Release date:2018-05-23
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor.
Biochem. J., 475, 2018
6GG6
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CRYSTAL STRUCTURE OF M2 PYK IN COMPLEX WITH SERINE.
Descriptor:Pyruvate kinase PKM, POTASSIUM ION, MAGNESIUM ION, ...
Authors:McNae, I.W., Yuan, M., Walkinshaw, M.D.
Deposit date:2018-05-02
Release date:2018-05-23
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (2.96 Å)
Cite:An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor.
Biochem. J., 475, 2018
6NC2
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AMC011 V4.2 SOSIP ENV TRIMER IN COMPLEX WITH FUSION PEPTIDE TARGETING ANTIBODY ACS202 FRAGMENT ANTIGEN BINDING
Descriptor:AMC011 v4.2 SOSIP gp120, AMC011 v4.2 SOSIP gp41, Monoclonal antibody ACS202 fragment antigen binding heavy chain, ...
Authors:Cottrell, C.A., Ozorowski, G., Yuan, M., Copps, J., Wilson, I.A., Ward, A.B.
Deposit date:2018-12-10
Release date:2019-06-19
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (5.2 Å)
Cite:Conformational Plasticity in the HIV-1 Fusion Peptide Facilitates Recognition by Broadly Neutralizing Antibodies.
Cell Host Microbe, 25, 2019
6VSR
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CRYSTAL STRUCTURE OF MACAQUE ANTI-HIV-1 ANTIBODY RM20F
Descriptor:RM20F Fab Heavy Chain, RM20F Fab Light Chain, SULFATE ION
Authors:Oyen, D., Yuan, M., Wilson, I.A.
Deposit date:2020-02-11
Release date:2020-09-16
Method:X-RAY DIFFRACTION (2.176 Å)
Cite:Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates.
Plos Pathog., 16, 2020
6XKP
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CRYSTAL STRUCTURE OF SARS-COV-2 RECEPTOR BINDING DOMAIN IN COMPLEX WITH NEUTRALIZING ANTIBODY CV07-270
Descriptor:Spike protein S1, CV07-270 Heavy Chain, CV07-270 Light Chain, ...
Authors:Liu, H., Yuan, M., Zhu, X., Wu, N.C., Wilson, I.A.
Deposit date:2020-06-26
Release date:2020-10-14
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:A therapeutic non-self-reactive SARS-CoV-2 antibody protects from lung pathology in a COVID-19 hamster model
Cell(Cambridge,Mass.), 2020
3IT4
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THE CRYSTAL STRUCTURE OF ORNITHINE ACETYLTRANSFERASE FROM MYCOBACTERIUM TUBERCULOSIS (RV1653) AT 1.7 A
Descriptor:Arginine biosynthesis bifunctional protein argJ alpha chain, Arginine biosynthesis bifunctional protein argJ beta chain, GLYCEROL, ...
Authors:Sankaranarayanan, R., Cherney, M.M., Garen, C., Garen, G., Yuan, M., James, M.N., TB Structural Genomics Consortium (TBSGC)
Deposit date:2009-08-27
Release date:2010-03-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The molecular structure of ornithine acetyltransferase from Mycobacterium tuberculosis bound to ornithine, a competitive inhibitor.
J.Mol.Biol., 397, 2010
3IT6
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THE CRYSTAL STRUCTURE OF ORNITHINE ACETYLTRANSFERASE COMPLEXED WITH ORNITHINE FROM MYCOBACTERIUM TUBERCULOSIS (RV1653) AT 2.4 A
Descriptor:Arginine biosynthesis bifunctional protein argJ alpha chain, Arginine biosynthesis bifunctional protein argJ beta chain, L-ornithine
Authors:Sankaranarayanan, R., Cherney, M.M., Garen, C., Garen, G., Yuan, M., James, M.N., TB Structural Genomics Consortium (TBSGC)
Deposit date:2009-08-27
Release date:2010-03-02
Last modified:2014-06-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The molecular structure of ornithine acetyltransferase from Mycobacterium tuberculosis bound to ornithine, a competitive inhibitor.
J.Mol.Biol., 397, 2010
4KYH
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CRYSTAL STRUCTURE OF MOUSE GLYOXALASE I COMPLEXED WITH ZOPOLRESTAT
Descriptor:Lactoylglutathione lyase, ZINC ION, 3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACID
Authors:Zhai, J., Yuan, M., Zhang, L., Chen, Y., Zhang, H., Chen, S., Zhao, Y.
Deposit date:2013-05-29
Release date:2013-08-07
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Zopolrestat as a Human Glyoxalase I Inhibitor and Its Structural Basis
Chemmedchem, 2013
4KYK
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CRYSTAL STRUCTURE OF MOUSE GLYOXALASE I COMPLEXED WITH INDOMETHACIN
Descriptor:Lactoylglutathione lyase, ZINC ION, INDOMETHACIN
Authors:Zhai, J., Yuan, M., Zhang, L., Chen, Y., Zhang, H., Chen, S., Zhao, Y.
Deposit date:2013-05-29
Release date:2013-08-07
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Zopolrestat as a Human Glyoxalase I Inhibitor and Its Structural Basis
Chemmedchem, 2013
4RVP
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CRYSTAL STRUCTURE OF SUPEROXIDE DISMUTASE FROM SEDUM ALFREDII
Descriptor:superoxide dismutase, ZINC ION
Authors:Qiu, R., Li, C., Zhai, J., Tang, L., Zhang, H., Yuan, M., Hu, X.
Deposit date:2014-11-27
Release date:2015-12-16
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The positive effects of Cd and Cd-Zn relationship in the Zn-related physiological processes involved in growth in the Zn/Cd hyperaccumulator Sedum alfredii
To be Published
4WJ8
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HUMAN PYRUVATE KINASE M2 MUTANT C424A
Descriptor:Pyruvate kinase PKM, OXALIC ACID, 1,6-di-O-phosphono-beta-D-fructofuranose, ...
Authors:Mitchell, T., Yuan, M., McNae, I., Morgan, H., Walkinshaw, M.D.
Deposit date:2014-09-29
Release date:2015-09-30
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.87 Å)
Cite:Human Pyruvate Kinase M2 Mutant C424A
To Be Published
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169963
PDB entries from 2020-10-14