8D36

Crystal structure of SARS-CoV-2 fusion peptide in complex with neutralizing antibody COV44-62

Summary for 8D36

• Entry DOI: 10.2210/pdb8d36/pdb
• Descriptor: Neutralizing antibody COV44-62 heavy chain, Neutralizing antibody COV44-62 light chain, Spike protein S2 fusion peptide, ... (4 entities in total)
• Functional Keywords: sars-cov-2, coronavirus, antibody, fusion peptide, neutralizing antibody, covid-19, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 48689.42

Authors

Yuan, M.,Lee, C.C.D.,Wilson, I.A. (deposition date: 2022-05-31, release date: 2022-07-27, Last modification date: 2023-10-18)

• Primary citation: Dacon, C.,Tucker, C.,Peng, L.,Lee, C.D.,Lin, T.H.,Yuan, M.,Cong, Y.,Wang, L.,Purser, L.,Williams, J.K.,Pyo, C.W.,Kosik, I.,Hu, Z.,Zhao, M.,Mohan, D.,Cooper, A.J.R.,Peterson, M.,Skinner, J.,Dixit, S.,Kollins, E.,Huzella, L.,Perry, D.,Byrum, R.,Lembirik, S.,Drawbaugh, D.,Eaton, B.,Zhang, Y.,Yang, E.S.,Chen, M.,Leung, K.,Weinberg, R.S.,Pegu, A.,Geraghty, D.E.,Davidson, E.,Douagi, I.,Moir, S.,Yewdell, J.W.,Schmaljohn, C.,Crompton, P.D.,Holbrook, M.R.,Nemazee, D.,Mascola, J.R.,Wilson, I.A.,Tan, J.; Broadly neutralizing antibodies target the coronavirus fusion peptide.; Science, 377:728-735, 2022; PubMed: 35857439; DOI: 10.1126/science.abq3773

Experimental method

X-RAY DIFFRACTION (1.45 Å)