Author results

3O6F
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CRYSTAL STRUCTURE OF A HUMAN AUTOIMMUNE TCR MS2-3C8 BOUND TO MHC CLASS II SELF-LIGAND MBP/HLA-DR4
Descriptor:HLA class II histocompatibility antigen, DR alpha chain, DRB1-4 beta chain, ...
Authors:Yin, Y., Li, Y., Martin, R., Mariuzza, R.A.
Deposit date:2010-07-29
Release date:2011-03-02
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of a TCR with high affinity for self-antigen reveals basis for escape from negative selection.
Embo J., 30, 2011
4WV1
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CRYSTAL STRUCTURE OF THE FGFR2 D2 DOMAIN IN COMPLEX WITH FAB 2B.1.3
Descriptor:Fibroblast growth factor receptor 2, Fab heavy chain, Fab light chain
Authors:Yin, Y., Carter, P.J.
Deposit date:2014-11-04
Release date:2015-09-16
Last modified:2015-10-14
Method:X-RAY DIFFRACTION (2.362 Å)
Cite:Redesigning a Monospecific Anti-FGFR3 Antibody to Add Selectivity for FGFR2 and Expand Antitumor Activity.
Mol.Cancer Ther., 14, 2015
2GFP
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STRUCTURE OF THE MULTIDRUG TRANSPORTER EMRD FROM ESCHERICHIA COLI
Descriptor:Multidrug resistance protein D
Authors:Yin, Y., He, X., Szewczyk, P., Nguyen, T., Chang, G.
Deposit date:2006-03-22
Release date:2006-05-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structure of the multidrug transporter EmrD from Escherichia coli
Science, 312, 2006
3T0E
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CRYSTAL STRUCTURE OF A COMPLETE TERNARY COMPLEX OF T CELL RECEPTOR, PEPTIDE-MHC AND CD4
Descriptor:HLA class II histocompatibility antigen, DR alpha chain, DRB1-4 beta chain, ...
Authors:Yin, Y., Mariuzza, R.A.
Deposit date:2011-07-20
Release date:2012-03-07
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (4 Å)
Cite:Crystal structure of a complete ternary complex of T-cell receptor, peptide-MHC, and CD4.
Proc.Natl.Acad.Sci.USA, 109, 2012
5TDN
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CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF ANTI-HER2 ANTIBODY 4D5 WITH REDESIGNED HEAVY AND LIGHT CHAIN INTERFACES
Descriptor:anti-HER2 Fab Light Chain, anti-HER2 Fab Heavy Chain, GLYCEROL
Authors:Yin, Y., Carter, P.J.
Deposit date:2016-09-19
Release date:2016-12-07
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Crystal structure of the Fab fragment of anti-HER2 antibody 4D5 with redesigned heavy and light chain interfaces
To Be Published
5TDO
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CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF ANTI-HER2 ANTIBODY 4D5 WITH REDESIGNED HEAVY AND LIGHT CHAIN INTERFACES
Descriptor:anti-HER2 Fab Light Chain, anti-HER2 Fab Heavy Chain, GLYCEROL
Authors:Yin, Y., Carter, P.J.
Deposit date:2016-09-19
Release date:2016-12-07
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Crystal structure of the Fab fragment of anti-HER2 antibody 4D5 with redesigned heavy and light chain interfaces
To Be Published
5TDP
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CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF ANTI-HER2 ANTIBODY 4D5 WITH REDESIGNED HEAVY AND LIGHT CHAIN INTERFACES
Descriptor:anti-HER2 Fab Light Chain, anti-HER2 Fab Heavy Chain, GLYCEROL
Authors:Yin, Y., Carter, P.J.
Deposit date:2016-09-19
Release date:2016-12-07
Method:X-RAY DIFFRACTION (1.716 Å)
Cite:Crystal structure of the Fab fragment of anti-HER2 antibody 4D5 with redesigned heavy and light chain interfaces
To Be Published
6BPQ
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STRUCTURE OF THE COLD- AND MENTHOL-SENSING ION CHANNEL TRPM8
Descriptor:Transient receptor potential cation channel subfamily M member 8
Authors:Yin, Y., Wu, M., Zubcevic, L., Borschel, W.F., Lander, G.C., Lee, S.-Y.
Deposit date:2017-11-25
Release date:2017-12-13
Last modified:2018-01-24
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structure of the cold- and menthol-sensing ion channel TRPM8.
Science, 359, 2018
5EF6
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STRUCTURE OF HOXB13 COMPLEX WITH METHYLATED DNA
Descriptor:Homeobox protein Hox-B13, DNA (5'-D(P*TP*TP*GP*TP*GP*TP*TP*TP*TP*AP*(5CM)P*GP*AP*GP*GP*TP*CP*C)-3'), DNA (5'-D(P*GP*GP*AP*CP*CP*TP*(5CM)P*GP*TP*AP*AP*AP*AP*CP*AP*CP*AP*A)-3')
Authors:Morgunova, E., Yin, Y., Jolma, A., Popov, A., Taipale, J.
Deposit date:2015-10-23
Release date:2017-02-08
Last modified:2017-05-17
Method:X-RAY DIFFRACTION (3 Å)
Cite:Impact of cytosine methylation on DNA binding specificities of human transcription factors.
Science, 356, 2017
5EGO
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HOXB13-MEIS1 HETERODIMER BOUND TO METHYLATED DNA
Descriptor:Homeobox protein Meis1, DNA (5'-D(P*GP*TP*TP*GP*AP*CP*AP*GP*TP*TP*TP*TP*AP*(5CM)P*GP*AP*GP*G)-3'), DNA (5'-D(*CP*CP*TP*(5CM)P*GP*TP*AP*AP*AP*AP*CP*TP*GP*TP*CP*AP*AP*C)-3'), ...
Authors:Morgunova, E., Yin, Y., Jolma, A., Popov, A., Taipale, J.
Deposit date:2015-10-27
Release date:2016-11-09
Last modified:2017-05-17
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Impact of cytosine methylation on DNA binding specificities of human transcription factors.
Science, 356, 2017
5HOD
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STRUCTURE OF LHX4 TRANSCRIPTION FACTOR COMPLEXED WITH DNA
Descriptor:LIM/homeobox protein Lhx4, DNA (5'-D(P*AP*CP*CP*TP*AP*AP*TP*TP*AP*GP*GP*CP*GP*TP*AP*AP*TP*TP*AP*G)-3'), DNA (5'-D(P*CP*TP*AP*AP*TP*TP*AP*CP*GP*CP*CP*TP*AP*AP*TP*TP*AP*GP*GP*T)-3')
Authors:Morgunova, E., Yin, Y., Popov, A., Taipale, J.
Deposit date:2016-01-19
Release date:2017-02-01
Last modified:2017-05-17
Method:X-RAY DIFFRACTION (2.682 Å)
Cite:Impact of cytosine methylation on DNA binding specificities of human transcription factors.
Science, 356, 2017
5V54
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CRYSTAL STRUCTURE OF 5-HT1B RECEPTOR IN COMPLEX WITH METHIOTHEPIN
Descriptor:5-hydroxytryptamine receptor 1B,OB-1 fused 5-HT1b receptor,5-hydroxytryptamine receptor 1B, 1-methyl-4-[(5~{S})-3-methylsulfanyl-5,6-dihydrobenzo[b][1]benzothiepin-5-yl]piperazine
Authors:Yin, W.C., Zhou, X.E., Yang, D., de Waal, P., Wang, M.T., Dai, A., Cai, X., Huang, C.Y., Liu, P., Yin, Y., Liu, B., Caffrey, M., Melcher, K., Xu, Y., Wang, M.W., Xu, H.E., Jiang, Y.
Deposit date:2017-03-13
Release date:2018-02-07
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:A common antagonistic mechanism for class A GPCRs revealed by the structure of the human 5-HT1B serotonin receptor bound to an antagonist
Cell Discov, 2018
5W0P
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CRYSTAL STRUCTURE OF RHODOPSIN BOUND TO VISUAL ARRESTIN DETERMINED BY X-RAY FREE ELECTRON LASER
Descriptor:Endolysin,Rhodopsin,S-arrestin, N-ACETYL-D-GLUCOSAMINE
Authors:Zhou, X.E., He, Y., de Waal, P.W., Gao, X., Kang, Y., Van Eps, N., Yin, Y., Pal, K., Goswami, D., White, T.A., Barty, A., Latorraca, N.R., Chapman, H.N., Hubbell, W.L., Dror, R.O., Stevens, R.C., Cherezov, V., Gurevich, V.V., Griffin, P.R., Ernst, O.P., Melcher, K., Xu, H.E.
Deposit date:2017-05-31
Release date:2017-08-09
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (3.013 Å)
Cite:Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors.
Cell, 170, 2017
1O8T
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GLOBAL STRUCTURE AND DYNAMICS OF HUMAN APOLIPOPROTEIN CII IN COMPLEX WITH MICELLES: EVIDENCE FOR INCREASED MOBILITY OF THE HELIX INVOLVED IN THE ACTIVATION OF LIPOPROTEIN LIPASE
Descriptor:APOLIPOPROTEIN C-II
Authors:Zdunek, J., Martinez, G.V., Schleucher, J., Lycksell, P.O., Yin, Y., Nilsson, S., Shen, Y., Olivecrona, G., Wijmenga, S.
Deposit date:2002-11-29
Release date:2003-02-27
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Global Structure and Dynamics of Human Apolipoprotein Cii in Complex with Micelles: Evidence for Increased Mobility of the Helix Involved in the Activation of Lipoprotein Lipase
Biochemistry, 42, 2003
5EDN
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STRUCTURE OF HOXB13-DNA(TCG) COMPLEX
Descriptor:Homeobox protein Hox-B13, DNA (5'-D(P*GP*TP*TP*GP*TP*GP*TP*TP*TP*TP*AP*CP*GP*AP*GP*GP*TP*CP*C)-3'), DNA (5'-D(P*GP*GP*AP*CP*CP*TP*CP*GP*TP*AP*AP*AP*AP*CP*AP*CP*AP*AP*C)-3'), ...
Authors:Morgunova, E., Yin, Y., Jolma, A., Popov, A., Taipale, J.
Deposit date:2015-10-21
Release date:2016-11-09
Last modified:2018-08-15
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Two distinct DNA sequences recognized by transcription factors represent enthalpy and entropy optima.
Elife, 7, 2018
5EEA
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STRUCTURE OF HOXB13-DNA(CAA) COMPLEX
Descriptor:DNA (5'-D(P*TP*TP*GP*TP*GP*TP*TP*TP*TP*AP*TP*TP*GP*GP*GP*TP*CP*C)-3'), DNA (5'-D(P*GP*GP*AP*CP*CP*CP*AP*AP*TP*AP*AP*AP*AP*CP*AP*CP*AP*A)-3'), Homeobox protein Hox-B13
Authors:Morgunova, E., Yin, Y., Jolma, A., Popov, A., Taipale, J.
Deposit date:2015-10-22
Release date:2016-10-26
Last modified:2018-08-15
Method:X-RAY DIFFRACTION (2.195 Å)
Cite:Two distinct DNA sequences recognized by transcription factors represent enthalpy and entropy optima.
Elife, 7, 2018
6ES2
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STRUCTURE OF CDX2-DNA(CAA)
Descriptor:DNA (5'-D(P*TP*TP*GP*TP*GP*TP*TP*TP*TP*AP*TP*TP*GP*CP*CP*TP*CP*C)-3'), Homeobox protein CDX-2, DNA (5'-D(P*GP*GP*AP*GP*GP*CP*AP*AP*TP*AP*AP*AP*AP*CP*AP*CP*AP*A)-3')
Authors:Morgunova, E., Yin, Y., Jolma, A., Popov, A., Taipale, J.
Deposit date:2017-10-19
Release date:2018-03-21
Last modified:2018-05-16
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Two distinct DNA sequences recognized by transcription factors represent enthalpy and entropy optima.
Elife, 7, 2018
6ES3
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STRUCTURE OF CDX2-DNA(TCG)
Descriptor:DNA (5'-D(P*TP*TP*GP*TP*GP*TP*TP*TP*TP*AP*CP*GP*AP*CP*CP*TP*CP*C)-3'), Homeobox protein CDX-2, DNA (5'-D(P*GP*GP*AP*GP*GP*TP*CP*GP*TP*AP*AP*AP*AP*CP*AP*CP*AP*A)-3')
Authors:Morgunova, E., Yin, Y., Jolma, A., Popov, A., Taipale, J.
Deposit date:2017-10-19
Release date:2018-03-21
Last modified:2018-05-16
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:Two distinct DNA sequences recognized by transcription factors represent enthalpy and entropy optima.
Elife, 7, 2018
1M83
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CRYSTAL STRUCTURE OF TRYPTOPHANYL-TRNA SYNTHETASE COMPLEXED WITH ATP IN A CLOSED, PRE-TRANSITION STATE CONFORMATION
Descriptor:Tryptophan-tRNA ligase, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Retailleau, P., Huang, X., Yin, Y., Hu, M., Weinreb, V., Vachette, P., Vonrhein, C., Bricogne, G., Roversi, P., Ilyin, V., Carter Jr., C.W.
Deposit date:2002-07-24
Release date:2002-12-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Interconversion of ATP binding and conformational free energies by tryptophanyl-tRNA synthetase: structures of ATP bound to open and closed, pre-transition-state conformations.
J.Mol.Biol., 325, 2003
1MAU
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CRYSTAL STRUCTURE OF TRYPTOPHANYL-TRNA SYNTHETASE COMPLEXED WITH ATP AND TRYPTOPHANAMIDE IN A PRE-TRANSITION STATE CONFORMATION
Descriptor:tryptophan-tRNA ligase, SODIUM ION, MAGNESIUM ION, ...
Authors:Retailleau, P., Huang, X., Yin, Y., Hu, M., Weinreb, V., Vachette, P., Vonrhein, C., Bricogne, G., Roversi, P., Ilyin, V., Carter Jr., C.W.
Deposit date:2002-08-02
Release date:2003-01-07
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Interconversion of ATP binding and conformational free energies by tryptophanyl-tRNA synthetase: structures of ATP bound to open and closed, pre-transition-state conformations.
J.Mol.Biol., 325, 2003
1MAW
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CRYSTAL STRUCTURE OF TRYPTOPHANYL-TRNA SYNTHETASE COMPLEXED WITH ATP IN AN OPEN CONFORMATION
Descriptor:TRYPTOPHAN-TRNA LIGASE, ADENOSINE-5'-TRIPHOSPHATE
Authors:Retailleau, P., Huang, X., Yin, Y., Hu, M., Weinreb, V., Vachette, P., Vonrhein, C., Bricogne, G., Roversi, P., Ilyin, V., Carter Jr., C.W.
Deposit date:2002-08-02
Release date:2003-01-07
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (3 Å)
Cite:Interconversion of ATP binding and conformational free energies by tryptophanyl-tRNA synthetase: structures of ATP bound to open and closed, pre-transition-state conformations.
J.Mol.Biol., 325, 2003
1MB2
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CRYSTAL STRUCTURE OF TRYPTOPHANYL-TRNA SYNTHETASE COMPLEXED WITH TRYPTOPHAN IN AN OPEN CONFORMATION
Descriptor:TRYPTOPHAN-TRNA LIGASE, TRYPTOPHAN
Authors:Retailleau, P., Huang, X., Yin, Y., Hu, M., Weinreb, V., Vachette, P., Vonrhein, C., Bricogne, G., Roversi, P., Ilyin, V., Carter Jr., C.W.
Deposit date:2002-08-02
Release date:2003-01-07
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Interconversion of ATP binding and conformational free energies by tryptophanyl-tRNA synthetase: structures of ATP bound to open and closed, pre-transition-state conformations.
J.Mol.Biol., 325, 2003
1PES
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NMR SOLUTION STRUCTURE OF THE TETRAMERIC MINIMUM TRANSFORMING DOMAIN OF P53
Descriptor:TUMOR SUPPRESSOR P53
Authors:Lee, W., Harvey, T.S., Yin, Y., Yau, P., Litchfield, D., Arrowsmith, C.H.
Deposit date:1994-11-24
Release date:1995-02-07
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the tetrameric minimum transforming domain of p53.
Nat.Struct.Biol., 1, 1994
1PET
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NMR SOLUTION STRUCTURE OF THE TETRAMERIC MINIMUM TRANSFORMING DOMAIN OF P53
Descriptor:TUMOR SUPPRESSOR P53
Authors:Lee, W., Harvey, T.S., Yin, Y., Yau, P., Litchfield, D., Arrowsmith, C.H.
Deposit date:1994-11-24
Release date:1995-02-07
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the tetrameric minimum transforming domain of p53.
Nat.Struct.Biol., 1, 1994
3C8O
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THE CRYSTAL STRUCTURE OF RRAA FROM PAO1
Descriptor:Regulator of ribonuclease activity A, 1,2-ETHANEDIOL, TRIETHYLENE GLYCOL, ...
Authors:Luo, M., Niu, S., Yin, Y., Huang, A., Wang, D.
Deposit date:2008-02-12
Release date:2009-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The Crystal Structure of RraA from PAO1
To be published
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