3O6F

Crystal structure of a human autoimmune TCR MS2-3C8 bound to MHC class II self-ligand MBP/HLA-DR4

Summary for 3O6F

• Entry DOI: 10.2210/pdb3o6f/pdb
• Descriptor: HLA class II histocompatibility antigen, DR alpha chain, HLA class II histocompatibility antigen, DRB1-4 beta chain, T-cell receptor alpha chain C region, ... (5 entities in total)
• Functional Keywords: autoimmunity, multiple sclerosis, t cell receptor, hla class ii, protein-protein complex, immunoglobulin fold, membrane, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane; Single-pass type I membrane protein: P01903 P13760; Membrane ; Single-pass membrane protein : P01848 A0A5B9
• Total number of polymer chains: 8
• Total formula weight: 193200.94

Authors

Yin, Y.,Li, Y.,Martin, R.,Mariuzza, R.A. (deposition date: 2010-07-29, release date: 2011-03-02, Last modification date: 2023-09-06)

• Primary citation: Yin, Y.,Li, Y.,Kerzic, M.C.,Martin, R.,Mariuzza, R.A.; Structure of a TCR with high affinity for self-antigen reveals basis for escape from negative selection.; Embo J., 30:1137-1148, 2011; PubMed: 21297580; DOI: 10.1038/emboj.2011.21

Experimental method

X-RAY DIFFRACTION (2.8 Å)