3O6F

Crystal structure of a human autoimmune TCR MS2-3C8 bound to MHC class II self-ligand MBP/HLA-DR4

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E (A, E)	HLA class II histocompatibility antigen, DR alpha chain	polymer	182	21155.9	2	UniProt (P01903) Pfam (PF00993) Pfam (PF07654)	Homo sapiens (human)	MHC class II antigen DRA
2	B, F (B, F)	HLA class II histocompatibility antigen, DRB1-4 beta chain	polymer	221	25169.8	2	UniProt (P13760) Pfam (PF00969) Pfam (PF07654) UniProt (by SIFTS) (P01911)	Homo sapiens (human)	MHC class II antigen DRB1*4, DR-4, DR4
3	C, G (C, G)	T-cell receptor alpha chain C region	polymer	206	22743.1	2	UniProt (P01848) Pfam (PF09291)	Homo sapiens (human)
4	D, H (D, H)	T-cell receptor beta-1 chain C region	polymer	245	27531.7	2	UniProt (A0A5B9) Pfam (PF07654)	Homo sapiens (human)
5	I, J, K, L, M... (A, B, C, D, E...)	water	water		18.0	27	Chemie (HOH)

Sequence modifications

B, F: 1 - 30 (PDB: 3O6F)
B, F: 31 - 221 (UniProt: P13760)
C, G: -1 - 108 (PDB: 3O6F)
C, G: 109 - 200 (UniProt: P01848)
D, H: 1 - 115 (PDB: 3O6F)
D, H: 116 - 245 (UniProt: A0A5B9)

PDB	External Database	Details
Ser 189	Cys 74	engineered mutation

Sequence viewer

Contents of the asymmetric unit

*Water molecules are not included.