3O6F
Crystal structure of a human autoimmune TCR MS2-3C8 bound to MHC class II self-ligand MBP/HLA-DR4
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006955 | biological_process | immune response |
| A | 0016020 | cellular_component | membrane |
| A | 0019882 | biological_process | antigen processing and presentation |
| A | 0042613 | cellular_component | MHC class II protein complex |
| B | 0006955 | biological_process | immune response |
| B | 0016020 | cellular_component | membrane |
| B | 0019882 | biological_process | antigen processing and presentation |
| B | 0042613 | cellular_component | MHC class II protein complex |
| E | 0006955 | biological_process | immune response |
| E | 0016020 | cellular_component | membrane |
| E | 0019882 | biological_process | antigen processing and presentation |
| E | 0042613 | cellular_component | MHC class II protein complex |
| F | 0006955 | biological_process | immune response |
| F | 0016020 | cellular_component | membrane |
| F | 0019882 | biological_process | antigen processing and presentation |
| F | 0042613 | cellular_component | MHC class II protein complex |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCQVEH |
| Chain | Residue | Details |
| B | TYR200-HIS206 | |
| A | TYR161-HIS167 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498 |
| Chain | Residue | Details |
| D | ASN184 | |
| H | ASN184 | |
| G | ASN142 | |
| G | ASN176 | |
| F | ALA87 | |
| F | ASN91 | |
| F | ASN111 | |
| F | TYR112 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498 |
| Chain | Residue | Details |
| C | ASN187 | |
| G | ASN187 | |
| E | GLY49 | |
| E | ALA52 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19303388, ECO:0000269|PubMed:24190431 |
| Chain | Residue | Details |
| B | GLY49 | |
| F | GLY49 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | SITE: Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819 |
| Chain | Residue | Details |
| A | SER53 | |
| E | SER53 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | SITE: Pathogen-derived peptide antigen => ECO:0000269|PubMed:23260142, ECO:0007744|PDB:4GBX |
| Chain | Residue | Details |
| A | GLU55 | |
| E | GLU55 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | SITE: Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4GBX |
| Chain | Residue | Details |
| A | ASN62 | |
| E | ASN62 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | SITE: Pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX |
| Chain | Residue | Details |
| A | ASN69 | |
| E | ASN69 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | SITE: Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX |
| Chain | Residue | Details |
| A | ARG76 | |
| E | ARG76 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7477400 |
| Chain | Residue | Details |
| A | ASN78 | |
| A | ASN118 | |
| E | ASN78 | |
| E | ASN118 |
