3O6F
Crystal structure of a human autoimmune TCR MS2-3C8 bound to MHC class II self-ligand MBP/HLA-DR4
Summary for 3O6F
Entry DOI | 10.2210/pdb3o6f/pdb |
Descriptor | HLA class II histocompatibility antigen, DR alpha chain, HLA class II histocompatibility antigen, DRB1-4 beta chain, T-cell receptor alpha chain C region, ... (5 entities in total) |
Functional Keywords | autoimmunity, multiple sclerosis, t cell receptor, hla class ii, protein-protein complex, immunoglobulin fold, membrane, immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Cell membrane; Single-pass type I membrane protein: P01903 P13760 Membrane ; Single-pass membrane protein : P01848 A0A5B9 |
Total number of polymer chains | 8 |
Total formula weight | 193200.94 |
Authors | Yin, Y.,Li, Y.,Martin, R.,Mariuzza, R.A. (deposition date: 2010-07-29, release date: 2011-03-02, Last modification date: 2023-09-06) |
Primary citation | Yin, Y.,Li, Y.,Kerzic, M.C.,Martin, R.,Mariuzza, R.A. Structure of a TCR with high affinity for self-antigen reveals basis for escape from negative selection. Embo J., 30:1137-1148, 2011 Cited by PubMed: 21297580DOI: 10.1038/emboj.2011.21 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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