Author results

6BZ9
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CRYSTAL STRUCTURE OF HUMAN CASPASE-1 IN COMPLEX WITH AC-FLTD-CMK
Descriptor:Caspase-1, Ac-FLTD-CMK, DI(HYDROXYETHYL)ETHER
Authors:Xiao, T.S., Yang, J., Liu, Z., Wang, C., Yang, R.
Deposit date:2017-12-22
Release date:2018-06-13
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (1.796 Å)
Cite:Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
3VD8
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CRYSTAL STRUCTURE OF HUMAN AIM2 PYD DOMAIN WITH MBP FUSION
Descriptor:Maltose-binding periplasmic protein, Interferon-inducible protein AIM2, 1,2-ETHANEDIOL, ...
Authors:Jin, T.C., Perry, A., Smith, P., Xiao, T.S.
Deposit date:2012-01-04
Release date:2013-01-16
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.0685 Å)
Cite:Structure of the Absent in Melanoma 2 (AIM2) Pyrin Domain Provides Insights into the Mechanisms of AIM2 Autoinhibition and Inflammasome Assembly.
J.Biol.Chem., 288, 2013
4EO7
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CRYSTAL STRUCTURE OF THE TIR DOMAIN OF HUMAN MYELOID DIFFERENTIATION PRIMARY RESPONSE PROTEIN 88.
Descriptor:Myeloid differentiation primary response protein MyD88, MAGNESIUM ION
Authors:Snyder, G.A., Cirl, C., Jiang, J.S., Chen, P., Smith, T., Xiao, T.S.
Deposit date:2012-04-13
Release date:2013-04-10
Last modified:2013-05-08
Method:X-RAY DIFFRACTION (1.449 Å)
Cite:Molecular mechanisms for the subversion of MyD88 signaling by TcpC from virulent uropathogenic Escherichia coli.
Proc.Natl.Acad.Sci.USA, 110, 2013
4LQC
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THE CRYSTAL STRUCTURES OF THE BRUCELLA PROTEIN TCPB AND THE TLR ADAPTOR PROTEIN TIRAP SHOW STRUCTURAL DIFFERENCES IN MICROBIAL TIR MIMICRY.
Descriptor:TcpB
Authors:Snyder, G.A., Smith, P., Fresquez, T., Cirl, C., Jiang, J., Snyder, N., Luchetti, T., Miethke, T., Xiao, T.S.
Deposit date:2013-07-17
Release date:2013-12-04
Last modified:2014-04-09
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of the Toll/Interleukin-1 receptor (TIR) domains from the Brucella protein TcpB and host adaptor TIRAP reveal mechanisms of molecular mimicry.
J.Biol.Chem., 289, 2014
4LQD
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THE CRYSTAL STRUCTURES OF THE BRUCELLA PROTEIN TCPB AND THE TLR ADAPTOR PROTEIN TIRAP SHOW STRUCTURAL DIFFERENCES IN MICROBIAL TIR MIMICRY
Descriptor:Toll/interleukin-1 receptor domain-containing adapter protein, GLYCEROL
Authors:Snyder, G.A., Smith, P., Jiang, J., Xiao, T.S.
Deposit date:2013-07-17
Release date:2013-12-04
Last modified:2014-04-09
Method:X-RAY DIFFRACTION (2.451 Å)
Cite:Crystal structures of the Toll/Interleukin-1 receptor (TIR) domains from the Brucella protein TcpB and host adaptor TIRAP reveal mechanisms of molecular mimicry.
J.Biol.Chem., 289, 2014
4M6B
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CRYSTAL STRUCTURE OF YEAST SWR1-Z DOMAIN IN COMPLEX WITH H2A.Z-H2B DIMER
Descriptor:Chimera protein of Histone H2B.1 and Histone H2A.Z, Helicase SWR1
Authors:Hong, J.J., Feng, H.Q., Wang, F., Ranjan, A., Chen, J.H., Jiang, J.S., Girlando, R., Xiao, T.S., Wu, C., Bai, Y.W.
Deposit date:2013-08-09
Release date:2014-02-19
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:The Catalytic Subunit of the SWR1 Remodeler Is a Histone Chaperone for the H2A.Z-H2B Dimer.
Mol.Cell, 53, 2014
4QLC
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CRYSTAL STRUCTURE OF CHROMATOSOME AT 3.5 ANGSTROM RESOLUTION
Descriptor:DNA (167-mer), Histone H3, Histone H4, ...
Authors:Jiang, J.S., Zhou, B.R., Xiao, T.S., Bai, Y.W.
Deposit date:2014-06-11
Release date:2015-07-22
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.503 Å)
Cite:Structural Mechanisms of Nucleosome Recognition by Linker Histones.
Mol.Cell, 33 Suppl 1, 2015
5H7N
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CRYSTAL STRUCTURE OF HUMAN NLRP12-PYD WITH A MBP TAG
Descriptor:NLRP12-PYD with MBP tag, MALTOTETRAOSE, SULFATE ION, ...
Authors:Jin, T.C., Xiao, T.S.
Deposit date:2016-11-19
Release date:2017-02-15
Method:X-RAY DIFFRACTION (1.849 Å)
Cite:Design of an expression system to enhance MBP-mediated crystallization
Sci Rep, 7, 2017
5H7Q
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CRYSTAL STRUCTURE OF HUMAN MNDA PYD DOMAIN WITH MBP TAG
Descriptor:MNDA PYD domain with MBP tag, MALTOSE, ACETATE ION
Authors:Jin, T.C., Xiao, T.S.
Deposit date:2016-11-20
Release date:2017-02-15
Method:X-RAY DIFFRACTION (1.451 Å)
Cite:Design of an expression system to enhance MBP-mediated crystallization
Sci Rep, 7, 2017
5WPZ
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CRYSTAL STRUCTURE OF MNDA PYD WITH MBP TAG
Descriptor:MBP-hMNDA-PYD, MALTOSE
Authors:Jin, T.C., Xiao, T.S.
Deposit date:2016-11-22
Release date:2017-02-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Design of an expression system to enhance MBP-mediated crystallization
Sci Rep, 7, 2017
5WQ6
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CRYSTAL STRUCTURE OF HMNDA-PYD WITH MBP TAG
Descriptor:MBP tagged hMNDA-PYD, MALTOSE, 1,2-ETHANEDIOL, ...
Authors:Jin, T.C., Xiao, T.S.
Deposit date:2016-11-23
Release date:2017-02-15
Method:X-RAY DIFFRACTION (1.648 Å)
Cite:Design of an expression system to enhance MBP-mediated crystallization
Sci Rep, 7, 2017
5Y3S
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CRYSTAL STRUCTURE OF HUMAN NLRP1 LEUCINE RICH REPEAT DOMAIN
Descriptor:NACHT, LRR and PYD domains-containing protein 1, PHOSPHATE ION, ...
Authors:Jin, T., Xiao, T.S.
Deposit date:2017-07-30
Release date:2018-08-01
Last modified:2018-10-17
Method:X-RAY DIFFRACTION (2.451 Å)
Cite:Crystal structure of human NLRP1 LRR domain
To Be Published
5Z7D
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P204HINAB-DSDNA COMPLEX STRUCTURE
Descriptor:Interferon-activable protein 204, DNA (5'-D(P*CP*CP*AP*TP*CP*AP*GP*AP*AP*AP*GP*AP*GP*AP*GP*C)-3')
Authors:Jin, T., Jiang, J., Xiao, T.S.
Deposit date:2018-01-28
Release date:2019-01-30
Method:X-RAY DIFFRACTION (4.504 Å)
Cite:p204-HINab:dsDNA complex structure
To Be Published
6AO3
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CRYSTAL STRUCTURE OF THE MURINE GASDERMIN D C-TERMINAL DOMAIN
Descriptor:Gasdermin-D
Authors:Liu, Z., Wang, C., Yang, J., Xiao, T.S.
Deposit date:2017-08-15
Release date:2018-04-11
Last modified:2018-05-09
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Structures of the Gasdermin D C-Terminal Domains Reveal Mechanisms of Autoinhibition.
Structure, 26, 2018
6AO4
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CRYSTAL STRUCTURE OF THE HUMAN GASDERMIN D C-TERMINAL DOMAIN
Descriptor:Gasdermin-D
Authors:Liu, Z., Wang, C., Yang, J., Xiao, T.S.
Deposit date:2017-08-15
Release date:2018-04-11
Last modified:2018-05-09
Method:X-RAY DIFFRACTION (2.901 Å)
Cite:Structures of the Gasdermin D C-Terminal Domains Reveal Mechanisms of Autoinhibition.
Structure, 26, 2018
3R9M
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CRYSTAL STRUCTURE OF THE BROX BRO1 DOMAIN
Descriptor:BRO1 domain-containing protein BROX, 1,2-ETHANEDIOL, FORMIC ACID
Authors:Mu, R.L., Jiang, J.S., Snyder, G., Smith, P., Xiao, T.
Deposit date:2011-03-25
Release date:2011-09-14
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The Phe105 Loop of Alix Bro1 Domain Plays a Key Role in HIV-1 Release.
Structure, 19, 2011
3RAU
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CRYSTAL STRUCTURE OF THE HD-PTP BRO1 DOMAIN
Descriptor:Tyrosine-protein phosphatase non-receptor type 23, ACETATE ION, 1,2-ETHANEDIOL, ...
Authors:Mu, R.L., Jiang, J.S., Snyder, G., Smith, P., Xiao, T.
Deposit date:2011-03-28
Release date:2011-09-14
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The Phe105 Loop of Alix Bro1 Domain Plays a Key Role in HIV-1 Release.
Structure, 19, 2011
3RLN
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STRUCTURAL BASIS OF CYTOSOLIC DNA RECOGNITION BY INNATE IMMUNE RECEPTORS
Descriptor:Gamma-interferon-inducible protein 16
Authors:Jin, T.C., Xiao, T.
Deposit date:2011-04-19
Release date:2012-04-25
Last modified:2012-05-09
Method:X-RAY DIFFRACTION (2.251 Å)
Cite:Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor.
Immunity, 36, 2012
3RLO
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STRUCTURAL BASIS OF CYTOSOLIC DNA RECOGNITION BY INNATE RECEPTORS
Descriptor:Gamma-interferon-inducible protein 16, 1,2-ETHANEDIOL, FORMIC ACID
Authors:Jin, T.C., Xiao, T.
Deposit date:2011-04-19
Release date:2012-04-25
Last modified:2014-10-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor.
Immunity, 36, 2012
3RN2
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STRUCTURAL BASIS OF CYTOSOLIC DNA RECOGNITION BY INNATE IMMUNE RECEPTORS
Descriptor:Interferon-inducible protein AIM2, DNA (5'-D(*CP*CP*AP*TP*CP*AP*AP*AP*GP*AP*TP*CP*TP*TP*TP*GP*AP*TP*GP*G)-3'), 1,2-ETHANEDIOL
Authors:Jin, T.C., Xiao, T.
Deposit date:2011-04-21
Release date:2012-04-25
Last modified:2012-05-09
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor.
Immunity, 36, 2012
3RN5
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STRUCTURAL BASIS OF CYTOSOLIC DNA RECOGNITION BY INNATE IMMUNE RECEPTORS
Descriptor:Interferon-inducible protein AIM2, DNA (5'-D(*CP*CP*AP*TP*CP*AP*AP*AP*GP*AP*GP*AP*GP*AP*AP*AP*GP*AP*G)-3'), DNA (5'-D(*GP*CP*TP*CP*TP*TP*TP*CP*TP*CP*TP*CP*TP*TP*TP*GP*AP*TP*G)-3'), ...
Authors:Jin, T.C., Xiao, T.
Deposit date:2011-04-21
Release date:2012-04-25
Last modified:2012-05-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor.
Immunity, 36, 2012
3RNU
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STRUCTURAL BASIS OF CYTOSOLIC DNA SENSING BY INNATE IMMUNE RECEPTORS
Descriptor:Gamma-interferon-inducible protein 16, DNA (5'-D(*GP*CP*CP*AP*TP*CP*AP*AP*AP*GP*AP*GP*AP*GP*AP*G)-3'), DNA (5'-D(*TP*CP*TP*CP*TP*CP*TP*TP*TP*GP*AP*TP*GP*GP*CP*C)-3'), ...
Authors:Jin, T.C., Xiao, T.
Deposit date:2011-04-22
Release date:2012-04-25
Last modified:2015-01-28
Method:X-RAY DIFFRACTION (2.502 Å)
Cite:Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor.
Immunity, 36, 2012
3ULY
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CRYSTAL STRUCTURE OF BROX BRO1 DOMAIN IN COMPLEX WITH THE C-TERMINAL TAILS OF CHMP5
Descriptor:BRO1 domain-containing protein BROX, Charged multivesicular body protein 5, GLYCEROL
Authors:Jiang, J.S., Mu, R.L., Xiao, T.
Deposit date:2011-11-11
Release date:2012-04-18
Last modified:2012-05-23
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Two Distinct Binding Modes Define the Interaction of Brox with the C-Terminal Tails of CHMP5 and CHMP4B.
Structure, 20, 2012
3UM0
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CRYSTAL STRUCTURE OF THE BROX BRO1 DOMAIN IN COMPLEX WITH THE C-TERMINAL TAIL OF CHMP5
Descriptor:BRO1 domain-containing protein BROX, Charged multivesicular body protein 5, GLYCEROL
Authors:Jiang, J.S., Mu, R.L., Xiao, T.
Deposit date:2011-11-11
Release date:2012-04-18
Last modified:2012-05-23
Method:X-RAY DIFFRACTION (3.102 Å)
Cite:Two Distinct Binding Modes Define the Interaction of Brox with the C-Terminal Tails of CHMP5 and CHMP4B.
Structure, 20, 2012
3UM1
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CRYSTAL STRUCTURE OF THE BROX BRO1 DOMAIN IN COMPLEX WITH THE C-TERMINAL TAIL OF CHMP5
Descriptor:BRO1 domain-containing protein BROX, Charged multivesicular body protein 5, GLYCEROL
Authors:Jiang, J.S., Mu, R.L., Xiao, T.
Deposit date:2011-11-11
Release date:2012-04-18
Last modified:2012-05-23
Method:X-RAY DIFFRACTION (2.708 Å)
Cite:Two Distinct Binding Modes Define the Interaction of Brox with the C-Terminal Tails of CHMP5 and CHMP4B.
Structure, 20, 2012
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