6BZ9
Crystal structure of human caspase-1 in complex with Ac-FLTD-CMK
Summary for 6BZ9
Entry DOI | 10.2210/pdb6bz9/pdb |
Descriptor | Caspase-1, Ac-FLTD-CMK, DI(HYDROXYETHYL)ETHER, ... (5 entities in total) |
Functional Keywords | inhibitor, complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 30893.88 |
Authors | Xiao, T.S.,Yang, J.,Liu, Z.,Wang, C.,Yang, R. (deposition date: 2017-12-22, release date: 2018-06-13, Last modification date: 2023-10-04) |
Primary citation | Yang, J.,Liu, Z.,Wang, C.,Yang, R.,Rathkey, J.K.,Pinkard, O.W.,Shi, W.,Chen, Y.,Dubyak, G.R.,Abbott, D.W.,Xiao, T.S. Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor. Proc. Natl. Acad. Sci. U.S.A., 115:6792-6797, 2018 Cited by PubMed: 29891674DOI: 10.1073/pnas.1800562115 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.796 Å) |
Structure validation
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