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6BZ9

Crystal structure of human caspase-1 in complex with Ac-FLTD-CMK

Functional Information from GO Data
ChainGOidnamespacecontents
A0004197molecular_functioncysteine-type endopeptidase activity
A0006508biological_processproteolysis
A0008234molecular_functioncysteine-type peptidase activity
B0004197molecular_functioncysteine-type endopeptidase activity
B0006508biological_processproteolysis
B0008234molecular_functioncysteine-type peptidase activity
Functional Information from PDB Data
site_idAC1
Number of Residues2
Detailsbinding site for residue PEG A 301
ChainResidue
ATRP145
AILE155

site_idAC2
Number of Residues8
Detailsbinding site for residue PEG A 302
ChainResidue
AHOH425
ASER159
ATHR212
AILE255
ALEU256
AGLN257
AALA260
AMET264

Functional Information from PROSITE/UniProt
site_idPS00455
Number of Residues12
DetailsAMP_BINDING Putative AMP-binding domain signature. MPTSSGSEGnVK
ChainResidueDetails
AMET123-LYS134

site_idPS01121
Number of Residues15
DetailsCASPASE_HIS Caspase family histidine active site. HktsdStfLvFMSHG
ChainResidueDetails
AHIS224-GLY238

site_idPS01122
Number of Residues12
DetailsCASPASE_CYS Caspase family cysteine active site. KPKVIIIQACRG
ChainResidueDetails
ALYS276-GLY287

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: ACT_SITE => ECO:0000269|PubMed:1574116
ChainResidueDetails
AHIS237

site_idSWS_FT_FI2
Number of Residues1
DetailsACT_SITE: ACT_SITE => ECO:0000269|PubMed:1574116, ECO:0000305|PubMed:32051255
ChainResidueDetails
ACYS285

site_idSWS_FT_FI3
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:30065070
ChainResidueDetails
ALYS134

Catalytic Information from CSA
site_idMCSA1
Number of Residues1
DetailsM-CSA 718
ChainResidueDetails
BGLU390electrostatic stabiliser
AGLY238electrostatic stabiliser
ACYS285nucleofuge, nucleophile, proton acceptor, proton donor
AARG286electrostatic stabiliser

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PDB entries from 2024-07-24

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