4LQC

The crystal structures of the Brucella protein TcpB and the TLR adaptor protein TIRAP show structural differences in microbial TIR mimicry.

Summary for 4LQC

Entry DOI	10.2210/pdb4lqc/pdb
Related	4LQD
Descriptor	TcpB (2 entities in total)
Functional Keywords	tir, tirap molecular mimic, myd88 binding, innate immunity, flavodoxin fold, bacterial tir like domain, myd88, proteolytic fragment from alpha 2 chymotrypsin, cytoplasmic, immune system
Biological source	Brucella melitensis
Total number of polymer chains	2
Total formula weight	33760.30
Authors	Snyder, G.A.,Smith, P.,Fresquez, T.,Cirl, C.,Jiang, J.,Snyder, N.,Luchetti, T.,Miethke, T.,Xiao, T.S. (deposition date: 2013-07-17, release date: 2013-12-04, Last modification date: 2024-02-28)
Primary citation	Snyder, G.A.,Deredge, D.,Waldhuber, A.,Fresquez, T.,Wilkins, D.Z.,Smith, P.T.,Durr, S.,Cirl, C.,Jiang, J.,Jennings, W.,Luchetti, T.,Snyder, N.,Sundberg, E.J.,Wintrode, P.,Miethke, T.,Xiao, T.S. Crystal structures of the Toll/Interleukin-1 receptor (TIR) domains from the Brucella protein TcpB and host adaptor TIRAP reveal mechanisms of molecular mimicry. J.Biol.Chem., 289:669-679, 2014 Cited by PubMed: 24275656 DOI: 10.1074/jbc.M113.523407 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation