4LQD

The crystal structures of the Brucella protein TcpB and the TLR adaptor protein TIRAP show structural differences in microbial TIR mimicry

Summary for 4LQD

Entry DOI	10.2210/pdb4lqd/pdb
Related	4LQC
Descriptor	Toll/interleukin-1 receptor domain-containing adapter protein, GLYCEROL (3 entities in total)
Functional Keywords	flavodoxin fold, toll-like receptor signaling adaptor, myd88, immune system
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P58753
Total number of polymer chains	1
Total formula weight	16100.38
Authors	Snyder, G.A.,Smith, P.,Jiang, J.,Xiao, T.S. (deposition date: 2013-07-17, release date: 2013-12-04, Last modification date: 2014-04-09)
Primary citation	Snyder, G.A.,Deredge, D.,Waldhuber, A.,Fresquez, T.,Wilkins, D.Z.,Smith, P.T.,Durr, S.,Cirl, C.,Jiang, J.,Jennings, W.,Luchetti, T.,Snyder, N.,Sundberg, E.J.,Wintrode, P.,Miethke, T.,Xiao, T.S. Crystal structures of the Toll/Interleukin-1 receptor (TIR) domains from the Brucella protein TcpB and host adaptor TIRAP reveal mechanisms of molecular mimicry. J.Biol.Chem., 289:669-679, 2014 Cited by PubMed: 24275656 DOI: 10.1074/jbc.M113.523407 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.451 Å)

Structure validation