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5K0K
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTO-ONCOGENE TYROSINE-PROTEIN KINASE MER IN COMPLEX WITH INHIBITOR UNC2434
Descriptor:Tyrosine-protein kinase Mer, CHLORIDE ION, 15-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}-4,5,6,7,9,10,11,12-octahydro-2,16-(azenometheno)pyrrolo[2,1-d][1,3,5,9]tetraazacyclotetradecin-8(3H)-one, ...
Authors:Wang, X., Liu, J., Zhang, W., Stashko, M.A., Nichols, J., DeRyckere, D., Miley, M.J., Norris-Drouin, J., Chen, Z., Machius, M., Wood, E., Graham, D.K., Earp, H.S., Graham, K., Kireev, D., Frye, S.V.
Deposit date:2016-05-17
Release date:2017-01-11
Method:X-RAY DIFFRACTION (2.545 Å)
Cite:Design and Synthesis of Novel Macrocyclic Mer Tyrosine Kinase Inhibitors.
ACS Med Chem Lett, 7, 2016
5K0X
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTO-ONCOGENE TYROSINE-PROTEIN KINASE MER IN COMPLEX WITH INHIBITOR UNC2541
Descriptor:Tyrosine-protein kinase Mer, CHLORIDE ION, (7S)-7-amino-N-[(4-fluorophenyl)methyl]-8-oxo-2,9,16,18,21-pentaazabicyclo[15.3.1]henicosa-1(21),17,19-triene-20-carboxamide
Authors:McIver, A.L., Zhang, W., Liu, Q., Jiang, X., Stashko, M.A., Nichols, J., Miley, M.J., Norris-Drouin, J., Machius, M., DeRyckere, D., Wood, E., Graham, D.K., Earp, H.S., Kireev, D., Frye, S.V., Wang, X.
Deposit date:2016-05-17
Release date:2017-02-22
Method:X-RAY DIFFRACTION (2.231 Å)
Cite:Discovery of Macrocyclic Pyrimidines as MerTK-Specific Inhibitors.
ChemMedChem, 12, 2017
4ZVZ
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CO-CRYSTAL STRUCTURES OF PP5 IN COMPLEX WITH 5-METHYL-7-OXABICYCLO[2.2.1]HEPTANE-2,3-DICARBOXYLIC ACID
Descriptor:Serine/threonine-protein phosphatase 5, MANGANESE (II) ION, (1R,2S,3R,4S,5S)-5-(propoxymethyl)-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid, ...
Authors:Chattopadhyay, D., Swingle, M.R., Salter, E.A., Wierzbicki, A., Honkanen, R.E.
Deposit date:2015-05-18
Release date:2016-04-27
Last modified:2017-02-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C.
Biochem. Pharmacol., 109, 2016
4ZX2
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CO-CRYSTAL STRUCTURES OF PP5 IN COMPLEX WITH 5-METHYL-7-OXABICYCLO[2.2.1]HEPTANE-2,3-DICARBOXYLIC ACID
Descriptor:Serine/threonine-protein phosphatase 5, MANGANESE (II) ION, (1S,2R,3S,4R,5S)-5-methyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid, ...
Authors:Chattopadhyay, D., Swingle, M.R., Salter, E.A., Wierzbicki, A., Honkanen, R.E.
Deposit date:2015-05-19
Release date:2016-04-27
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.23 Å)
Cite:Crystal structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C.
Biochem. Pharmacol., 109, 2016