7AAZ

Crystal structure of MerTK in complex with a type 1.5 aminopyridine inhibitor

Summary for 7AAZ

Entry DOI	10.2210/pdb7aaz/pdb
Related	7AAX 7AAY
Descriptor	Tyrosine-protein kinase Mer, 2-azanyl-~{N}-[(1~{S},2~{S})-2-[[4-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]phenyl]methoxy]cyclopentyl]-5-(1-methylpyrazol-4-yl)pyridine-3-carboxamide, CHLORIDE ION, ... (5 entities in total)
Functional Keywords	tyrosine kinase inhibitor, structure-based drug design, type 1.5 inhibitor, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	34916.95
Authors	Pflug, A.,Schimpl, M.,McCoull, W.,Nissink, J.W.M.,Overman, R.C.,Rawlins, P.B.,Truman, C.,Underwood, E.,Warwicker, J.,Winter-Holt, J. (deposition date: 2020-09-05, release date: 2020-11-04, Last modification date: 2024-01-31)
Primary citation	Pflug, A.,Schimpl, M.,Nissink, J.W.M.,Overman, R.C.,Rawlins, P.B.,Truman, C.,Underwood, E.,Warwicker, J.,Winter-Holt, J.,McCoull, W. A-loop interactions in Mer tyrosine kinase give rise to inhibitors with two-step mechanism and long residence time of binding. Biochem.J., 477:4443-4452, 2020 Cited by PubMed: 33119085 DOI: 10.1042/BCJ20200735 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.855 Å)

Structure validation