7AAZ
Crystal structure of MerTK in complex with a type 1.5 aminopyridine inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase Mer | polymer | 296 | 34000.4 | 1 | UniProt (Q12866) Pfam (PF07714) | Homo sapiens (Human) | Proto-oncogene c-Mer,Receptor tyrosine kinase MerTK |
| 2 | B (A) | 2-azanyl-~{N}-[(1~{S},2~{S})-2-[[4-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]phenyl]methoxy]cyclopentyl]-5-(1-methylpyrazol-4-yl)pyridine-3-carboxamide | non-polymer | 579.7 | 1 | Chemie (R6K) | |||
| 3 | C, D, E, F, G... (A) | CHLORIDE ION | non-polymer | 35.5 | 6 | Chemie (CL) | |||
| 4 | I, J (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 5 | K (A) | water | water | 18.0 | 132 | Chemie (HOH) |
Sequence modifications
A: 570 - 864 (UniProt: Q12866)
| PDB | External Database | Details |
|---|---|---|
| Gly 569 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34000.4 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 916.6 | |
| All* | Total formula weight | 34916.9 |
