7AAX
Crystal structure of MerTK kinase domain in complex with LDC1267
Summary for 7AAX
Entry DOI | 10.2210/pdb7aax/pdb |
Descriptor | Tyrosine-protein kinase Mer, ~{N}-[4-(6,7-dimethoxyquinolin-4-yl)oxy-3-fluoranyl-phenyl]-4-ethoxy-1-(4-fluoranyl-2-methyl-phenyl)pyrazole-3-carboxamide, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | tyrosine kinase inhibitor, structure-based drug design, type 2 inhibitor, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 35048.66 |
Authors | Schimpl, M.,Pflug, A.,McCoull, W.,Nissink, J.W.M.,Overman, R.C.,Rawlins, P.B.,Truman, C.,Underwood, E.,Warwicker, J.,Winter-Holt, J. (deposition date: 2020-09-05, release date: 2020-10-28, Last modification date: 2024-01-31) |
Primary citation | Pflug, A.,Schimpl, M.,Nissink, J.W.M.,Overman, R.C.,Rawlins, P.B.,Truman, C.,Underwood, E.,Warwicker, J.,Winter-Holt, J.,McCoull, W. A-loop interactions in Mer tyrosine kinase give rise to inhibitors with two-step mechanism and long residence time of binding. Biochem.J., 477:4443-4452, 2020 Cited by PubMed: 33119085DOI: 10.1042/BCJ20200735 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.762 Å) |
Structure validation
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