7AAX

Crystal structure of MerTK kinase domain in complex with LDC1267

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue R6H A 901

Chain	Residue
A	VAL601
A	MET674
A	LYS675
A	MET730
A	ALA740
A	ASP741
A	PHE742
A	ALA617
A	LYS619
A	PHE634
A	MET641
A	ILE650
A	LEU652
A	LEU671
A	PRO672

---

site_id	AC2
Number of Residues	1
Details	binding site for residue CL A 902

Chain	Residue
A	LYS820

---

site_id	AC3
Number of Residues	4
Details	binding site for residue CL A 903

Chain	Residue
A	ARG687
A	ARG687
A	MET798
A	HOH1050

---

site_id	AC4
Number of Residues	3
Details	binding site for residue CL A 904

Chain	Residue
A	ARG584
A	ILE588
A	LEU589

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	27
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGEFGSVMeGnlkqedgtslk.......VAVK

Chain	Residue	Details
A	LEU593-LYS619

---

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FLHrDLAARNCML

Chain	Residue	Details
A	PHE719-LEU731

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---