Summary for 5K0K
| Related | 5K0X |
|---|---|
| Descriptor | Tyrosine-protein kinase Mer, CHLORIDE ION, 15-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}-4,5,6,7,9,10,11,12-octahydro-2,16-(azenometheno)pyrrolo[2,1-d][1,3,5,9]tetraazacyclotetradecin-8(3H)-one, ... (5 entities in total) |
| Functional Keywords | macrocyclic, pyrrolopyrimidines, drug design, fibrinolytic agents, protein kinase inhibitors, proto-oncogene proteins, pyrimidines, receptor protein-tyrosine kinases, structure-activity relationship, thrombosis, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (Human) |
| Cellular location | Membrane ; Single-pass type I membrane protein Q12866 |
| Total number of polymer chains | 2 |
| Total molecular weight | 72939.09 |
| Authors | Wang, X.,Liu, J.,Zhang, W.,Stashko, M.A.,Nichols, J.,DeRyckere, D.,Miley, M.J.,Norris-Drouin, J.,Chen, Z.,Machius, M.,Wood, E.,Graham, D.K.,Earp, H.S.,Graham, K.,Kireev, D.,Frye, S.V. (deposition date: 2016-05-17, release date: 2017-01-11) |
| Primary citation | Wang, X.,Liu, J.,Zhang, W.,Stashko, M.A.,Nichols, J.,Miley, M.J.,Norris-Drouin, J.,Chen, Z.,Machius, M.,DeRyckere, D.,Wood, E.,Graham, D.K.,Earp, H.S.,Kireev, D.,Frye, S.V. Design and Synthesis of Novel Macrocyclic Mer Tyrosine Kinase Inhibitors. ACS Med Chem Lett, 7:1044-1049, 2016 PubMed: 27994735 (PDB entries with the same primary citation) DOI: 10.1021/acsmedchemlett.6b00221  Import into Mendeley |
| Experimental method | X-RAY DIFFRACTION (2.545 Å) |
