Author results

2HC1
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ENGINEERED CATALYTIC DOMAIN OF PROTEIN TYROSINE PHOSPHATASE HPTPBETA.
分子名称:Receptor-type tyrosine-protein phosphatase beta, ACETATE ION, CHLORIDE ION
著者Evdokimov, A.G., Pokross, M., Walter, R., Mekel, M.
登録日2006-06-14
公開日2006-06-27
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Engineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery.
Acta Crystallogr.,Sect.D, 62, 2006
2HC2
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ENGINEERED PROTEIN TYROSINE PHOSPHATASE BETA CATALYTIC DOMAIN
分子名称:Receptor-type tyrosine-protein phosphatase beta, MAGNESIUM ION, SODIUM ION
著者Evdokimov, A.G., Pokross, M., Walter, R., Mekel, M.
登録日2006-06-15
公開日2006-06-27
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Engineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery.
Acta Crystallogr.,Sect.D, 62, 2006
1OS1
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STRUCTURE OF PHOSPHOENOLPYRUVATE CARBOXYKINASE COMPLEXED WITH ATP,MG, CA AND PYRUVATE.
分子名称:Phosphoenolpyruvate carboxykinase [ATP], MAGNESIUM ION, CALCIUM ION, ...
著者Sudom, A., Walters, R., Pastushok, L., Goldie, D., Prasad, L., Delbaere, L.T., Goldie, H.
登録日2003-03-18
公開日2003-09-23
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Mechanisms of activation of phosphoenolpyruvate carboxykinase from Escherichia coli by Ca2+ and of desensitization by trypsin.
J.BACTERIOL., 185, 2003
1YGE
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LIPOXYGENASE-1 (SOYBEAN) AT 100K
分子名称:LIPOXYGENASE-1, FE (III) ION
著者Minor, W., Steczko, J., Stec, B., Otwinowski, Z., Bolin, J.T., Walter, R., Axelrod, B.
登録日1996-06-04
公開日1997-07-23
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Crystal structure of soybean lipoxygenase L-1 at 1.4 A resolution.
Biochemistry, 35, 1996
4POU
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VHH-METAL IN COMPLEX WITH RNASE A
分子名称:Ribonuclease pancreatic, VHH Antibody
著者Fanning, S.W., Walter, R., Horn, J.R.
登録日2014-02-26
公開日2014-09-24
最終更新日2014-10-22
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structural basis of an engineered dual-specific antibody: conformational diversity leads to a hypervariable loop metal-binding site.
Protein Eng.Des.Sel., 27, 2014
4POY
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ENGINEERED DUAL SPECIFIC VHH ANTIBODY
分子名称:VHH-metal
著者Fanning, S.W., Walter, R., Horn, J.R.
登録日2014-02-26
公開日2014-09-24
最終更新日2014-10-22
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural basis of an engineered dual-specific antibody: conformational diversity leads to a hypervariable loop metal-binding site.
Protein Eng.Des.Sel., 27, 2014
4PPT
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ENGINEERED DUAL SPECIFIC VHH ANTIBODY IN COMPLEX WITH A NICKEL (II) ION
分子名称:Engineered single domain VHH antibody, NICKEL (II) ION, SULFATE ION
著者Fanning, S.W., Walter, R., Horn, J.R.
登録日2014-02-27
公開日2014-09-03
最終更新日2014-10-22
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural basis of an engineered dual-specific antibody: conformational diversity leads to a hypervariable loop metal-binding site.
Protein Eng.Des.Sel., 27, 2014
4XI3
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ESTROGEN RECEPTOR ALPHA LIGAND BINDING DOMAIN IN COMPLEX WITH BAZEDOXIFENE
分子名称:Estrogen receptor, Bazedoxifene
著者Fanning, S.W., Mayne, C.G., Toy, W., Carlson, K., Greene, B., Nowak, J., Walter, R., Panchamukhi, S., Tajhorshid, E., Nettles, K.W., Chandarlapaty, S., Katzenellenbogen, J., Greene, G.L.
登録日2015-01-06
公開日2016-01-13
最終更新日2019-04-10
実験手法X-RAY DIFFRACTION (2.491 Å)
主引用文献Biochemical and Structural Basis for Constitutive Activity and Reduced SERM Potency in Acquired SERM/AI Resistant Metastatic Breast Cancers via ESR1 Somatic Mutation
To Be Published
2I3R
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ENGINEERED CATALYTIC DOMAIN OF PROTEIN TYROSINE PHOSPHATASE HPTPBETA
分子名称:Receptor-type tyrosine-protein phosphatase beta, CHLORIDE ION
著者Evdokimov, A.G., Pokross, M.E., Walter, R.L., Mekel, M.
登録日2006-08-20
公開日2006-08-29
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Engineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery.
Acta Crystallogr.,Sect.D, 62, 2006
2I3U
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STRUCTURAL STUDIES OF PROTEIN TYROSINE PHOSPHATASE BETA CATALYTIC DOMAIN IN COMPLEX WITH INHIBITORS
分子名称:Receptor-type tyrosine-protein phosphatase beta
著者Evdokimov, A.G., Pokross, M.E., Walter, R.L., Mekel, M.
登録日2006-08-20
公開日2006-08-29
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Engineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery.
Acta Crystallogr.,Sect.D, 62, 2006
2I4E
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STRUCTURAL STUDIES OF PROTEIN TYROSINE PHOSPHATASE BETA CATALYTIC DOMAIN IN COMPLEX WITH INHIBITORS
分子名称:Receptor-type tyrosine-protein phosphatase beta, VANADATE ION
著者Evdokimov, A.G., Pokross, M.E., Walter, R.L., Mekel, M.
登録日2006-08-21
公開日2006-08-29
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Engineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery.
Acta Crystallogr.,Sect.D, 62, 2006
2I4G
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STRUCTURAL STUDIES OF PROTEIN TYROSINE PHOSPHATASE BETA CATALYTIC DOMAIN IN COMPLEX WITH A SULFAMIC ACID (SOAKING EXPERIMENT)
分子名称:Receptor-type tyrosine-protein phosphatase beta, CHLORIDE ION, N-(TERT-BUTOXYCARBONYL)-L-TYROSYL-N-METHYL-4-(SULFOAMINO)-L-PHENYLALANINAMIDE
著者Evdokimov, A.G., Pokross, M.E., Walter, R.L., Mekel, M.
登録日2006-08-21
公開日2006-08-29
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Engineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery.
Acta Crystallogr.,Sect.D, 62, 2006
2I4H
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STRUCTURAL STUDIES OF PROTEIN TYROSINE PHOSPHATASE BETA CATALYTIC DOMAIN CO-CRYSTALLIZED WITH A SULFAMIC ACID INHIBITOR
分子名称:Receptor-type tyrosine-protein phosphatase beta, MAGNESIUM ION, CHLORIDE ION, ...
著者Evdokimov, A.G., Pokross, M.E., Walter, R.L., Mekel, M.
登録日2006-08-21
公開日2006-08-29
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Engineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery.
Acta Crystallogr.,Sect.D, 62, 2006
2I5X
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ENGINEERING THE PTPBETA CATALYTIC DOMAIN WITH IMPROVED CRYSTALLIZATION PROPERTIES
分子名称:Receptor-type tyrosine-protein phosphatase beta, CHLORIDE ION, (4-ETHYLPHENYL)SULFAMIC ACID, ...
著者Evdokimov, A.G., Pokross, M.E., Walter, R.L., Mekel, M., Klopfenstein, S.
登録日2006-08-26
公開日2006-09-05
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Engineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery.
Acta Crystallogr.,Sect.D, 62, 2006
2HFP
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CRYSTAL STRUCTURE OF PPAR GAMMA WITH N-SULFONYL-2-INDOLE CARBOXAMIDE LIGANDS
分子名称:Peroxisome proliferator-activated receptor gamma, SRC Peptide Fragment, 3-(4-METHOXYPHENYL)-N-(PHENYLSULFONYL)-1-[3-(TRIFLUOROMETHYL)BENZYL]-1H-INDOLE-2-CARBOXAMIDE
著者Pokross, M.E., Evdokimov, A.G., Walter, R.L., Mekel, M.J., Hopkins, C.R.
登録日2006-06-25
公開日2006-09-19
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-gamma binding agents with potential application to the treatment of osteoporosis.
Bioorg.Med.Chem.Lett., 16, 2006
2RHQ
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PHERS FROM STAPHYLOCOCCUS HAEMOLYTICUS- RATIONAL PROTEIN ENGINEERING AND INHIBITOR STUDIES
分子名称:Phenylalanyl-tRNA synthetase alpha chain, Phenylalanyl-tRNA synthetase beta chain, ZINC ION, ...
著者Evdokimov, A.G., Mekel, M.
登録日2007-10-09
公開日2007-11-06
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Rational protein engineering in action: the first crystal structure of a phenylalanine tRNA synthetase from Staphylococcus haemolyticus.
J.Struct.Biol., 162, 2008
2RHS
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PHERS FROM STAPHYLOCOCCUS HAEMOLYTICUS- RATIONAL PROTEIN ENGINEERING AND INHIBITOR STUDIES
分子名称:Phenylalanyl-tRNA synthetase alpha chain, Phenylalanyl-tRNA synthetase beta chain, 1-{3-[(4-pyridin-2-ylpiperazin-1-yl)sulfonyl]phenyl}-3-(1,3-thiazol-2-yl)urea, ...
著者Evdokimov, A.G., Mekel, M.
登録日2007-10-09
公開日2007-11-06
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Rational protein engineering in action: the first crystal structure of a phenylalanine tRNA synthetase from Staphylococcus haemolyticus.
J.Struct.Biol., 162, 2008
3D9A
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HIGH RESOLUTION CRYSTAL STRUCTURE STRUCTURE OF HYHEL10 FAB COMPLEXED TO HEN EGG LYSOZYME
分子名称:Lysozyme C, Light Chain of HyHel10 Antibody Fragment (Fab), Heavy Chain of HyHel10 Antibody Fragment (Fab)
著者DeSantis, M.E., Li, M., Shanmuganathan, A., Acchione, M., Walter, R., Wlodawer, A., Smith-Gill, S.
登録日2008-05-27
公開日2008-06-10
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Light chain somatic mutations change thermodynamics of binding and water coordination in the HyHEL-10 family of antibodies.
Mol.Immunol., 47, 2009
1F8N
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LIPOXYGENASE-1 (SOYBEAN) AT 100K, NEW REFINEMENT
分子名称:LIPOXYGENASE-1, FE (II) ION
著者Tomchick, D.R., Minor, W., Holman, T.
登録日2000-06-30
公開日2001-07-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structural and functional characterization of second-coordination sphere mutants of soybean lipoxygenase-1.
Biochemistry, 40, 2001
1FGM
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LIPOXYGENASE-1 (SOYBEAN) AT 100K, N694H MUTANT
分子名称:SEED LIPOXYGENASE-1, FE (III) ION
著者Tomchick, D.R., Minor, W., Holman, T.R.
登録日2000-07-28
公開日2001-10-24
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural and functional characterization of second-coordination sphere mutants of soybean lipoxygenase-1.
Biochemistry, 40, 2001
1FGO
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LIPOXYGENASE-1 (SOYBEAN) AT 100K, Q495A MUTANT
分子名称:SEED LIPOXYGENASE-1, FE (III) ION
著者Tomchick, D.R., Minor, W., Holman, T.
登録日2000-07-28
公開日2001-07-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.62 Å)
主引用文献Structural and functional characterization of second-coordination sphere mutants of soybean lipoxygenase-1.
Biochemistry, 40, 2001
1FGQ
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LIPOXYGENASE-1 (SOYBEAN) AT 100K, Q495E MUTANT
分子名称:SEED LIPOXYGENASE-1, FE (III) ION
著者Tomchick, D.R., Minor, W., Holman, T.
登録日2000-07-28
公開日2001-07-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structural and functional characterization of second-coordination sphere mutants of soybean lipoxygenase-1.
Biochemistry, 40, 2001
1FGR
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LIPOXYGENASE-1 (SOYBEAN) AT 100K, Q697E MUTANT
分子名称:SEED LIPOXYGENASE-1, FE (III) ION
著者Tomchick, D.R., Minor, W., Holman, T.
登録日2000-07-28
公開日2001-07-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural and functional characterization of second-coordination sphere mutants of soybean lipoxygenase-1.
Biochemistry, 40, 2001
1FGT
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LIPOXYGENASE-1 (SOYBEAN) AT 100K, Q697N MUTANT
分子名称:SEED LIPOXYGENASE-1, FE (III) ION
著者Tomchick, D.R., Minor, W., Holman, T.
登録日2000-07-28
公開日2001-07-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.62 Å)
主引用文献Structural and functional characterization of second-coordination sphere mutants of soybean lipoxygenase-1.
Biochemistry, 40, 2001
3PZW
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SOYBEAN LIPOXYGENASE-1 - RE-REFINEMENT
分子名称:Seed lipoxygenase-1, FE (II) ION, 1,2-ETHANEDIOL, ...
著者Chruszcz, M., Minor, W.
登録日2010-12-14
公開日2011-01-19
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Determination of protein structures - a series of fortunate events.
Biophys.J., 95, 2008