2I4G

Structural studies of protein tyrosine phosphatase beta catalytic domain in complex with a sulfamic acid (soaking experiment)

Summary for 2I4G

Entry DOI	10.2210/pdb2i4g/pdb
Related	2HC1 2HC2 2I3R 2I3U 2I4E 2I4H
Descriptor	Receptor-type tyrosine-protein phosphatase beta, CHLORIDE ION, N-(TERT-BUTOXYCARBONYL)-L-TYROSYL-N-METHYL-4-(SULFOAMINO)-L-PHENYLALANINAMIDE, ... (4 entities in total)
Functional Keywords	protein tyrosine phosphatase, wpd-loop, sulfamic acid, phosphatase, inhibitor, drug design, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass type I membrane protein (Potential): P23467
Total number of polymer chains	1
Total formula weight	36860.09
Authors	Evdokimov, A.G.,Pokross, M.E.,Walter, R.L.,Mekel, M. (deposition date: 2006-08-21, release date: 2006-08-29, Last modification date: 2023-08-30)
Primary citation	Evdokimov, A.G.,Pokross, M.,Walter, R.,Mekel, M.,Cox, B.,Li, C.,Bechard, R.,Genbauffe, F.,Andrews, R.,Diven, C.,Howard, B.,Rastogi, V.,Gray, J.,Maier, M.,Peters, K.G. Engineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery. Acta Crystallogr.,Sect.D, 62:1435-1445, 2006 Cited by PubMed: 17139078 DOI: 10.1107/S0907444906037784 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation