2I3R

Engineered catalytic domain of protein tyrosine phosphatase HPTPbeta

Summary for 2I3R

Entry DOI	10.2210/pdb2i3r/pdb
Related	2HC1 2HC2 2I3U
Descriptor	Receptor-type tyrosine-protein phosphatase beta, CHLORIDE ION (3 entities in total)
Functional Keywords	protein tyrosine phosphatase, wpd-loop, sulfamic acid, phosphatase, inhibitor, drug design, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass type I membrane protein (Potential): P23467
Total number of polymer chains	2
Total formula weight	72646.98
Authors	Evdokimov, A.G.,Pokross, M.E.,Walter, R.L.,Mekel, M. (deposition date: 2006-08-20, release date: 2006-08-29, Last modification date: 2023-08-30)
Primary citation	Evdokimov, A.G.,Pokross, M.,Walter, R.,Mekel, M.,Cox, B.,Li, C.,Bechard, R.,Genbauffe, F.,Andrews, R.,Diven, C.,Howard, B.,Rastogi, V.,Gray, J.,Maier, M.,Peters, K.G. Engineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery. Acta Crystallogr.,Sect.D, 62:1435-1445, 2006 Cited by PubMed: 17139078 DOI: 10.1107/S0907444906037784 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation