2I5X

Engineering the PTPbeta catalytic domain with improved crystallization properties

Summary for 2I5X

• Entry DOI: 10.2210/pdb2i5x/pdb
• Related: 2I4G 2I4H
• Descriptor: Receptor-type tyrosine-protein phosphatase beta, CHLORIDE ION, (4-ETHYLPHENYL)SULFAMIC ACID, ... (5 entities in total)
• Functional Keywords: protein tyrosine phosphatase, wpd-loop, drug design, protein engineering, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Membrane; Single-pass type I membrane protein (Potential): P23467
• Total number of polymer chains: 2
• Total formula weight: 73073.77

Authors

Evdokimov, A.G.,Pokross, M.E.,Walter, R.L.,Mekel, M.,Klopfenstein, S. (deposition date: 2006-08-26, release date: 2006-09-05, Last modification date: 2023-08-30)

• Primary citation: Evdokimov, A.G.,Pokross, M.,Walter, R.,Mekel, M.,Cox, B.,Li, C.,Bechard, R.,Genbauffe, F.,Andrews, R.,Diven, C.,Howard, B.,Rastogi, V.,Gray, J.,Maier, M.,Peters, K.G.; Engineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery.; Acta Crystallogr.,Sect.D, 62:1435-1445, 2006; PubMed: 17139078; DOI: 10.1107/S0907444906037784

Experimental method

X-RAY DIFFRACTION (1.7 Å)