2I5X
Engineering the PTPbeta catalytic domain with improved crystallization properties
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| A | 0006470 | biological_process | protein dephosphorylation |
| A | 0016311 | biological_process | dephosphorylation |
| B | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| B | 0006470 | biological_process | protein dephosphorylation |
| B | 0016311 | biological_process | dephosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG B 601 |
| Chain | Residue |
| B | HOH330 |
| B | HOH475 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 602 |
| Chain | Residue |
| A | ARG1743 |
| A | VAL1744 |
| A | TYR1757 |
| A | ILE1758 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 603 |
| Chain | Residue |
| B | HOH171 |
| B | CYS1804 |
| B | HIS1864 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE UA5 A 701 |
| Chain | Residue |
| A | TYR1733 |
| A | ASP1870 |
| A | HIS1871 |
| A | CYS1904 |
| A | SER1905 |
| A | ALA1906 |
| A | GLY1907 |
| A | VAL1908 |
| A | GLY1909 |
| A | ARG1910 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE UA5 B 702 |
| Chain | Residue |
| B | ASP1870 |
| B | HIS1871 |
| B | CYS1904 |
| B | SER1905 |
| B | ALA1906 |
| B | VAL1908 |
| B | GLY1909 |
| B | ARG1910 |
Functional Information from PROSITE/UniProt
| site_id | PS00383 |
| Number of Residues | 11 |
| Details | TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. VHCsaGvgRTG |
| Chain | Residue | Details |
| A | VAL1902-GLY1912 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Phosphocysteine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00160","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10044","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17139078","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1ytw |
| Chain | Residue | Details |
| A | ARG1910 | |
| A | GLU1806 | |
| A | CYS1904 | |
| A | ASP1870 | |
| A | THR1911 | |
| A | HIS1903 |
| site_id | CSA2 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1ytw |
| Chain | Residue | Details |
| B | ARG1910 | |
| B | GLU1806 | |
| B | CYS1904 | |
| B | ASP1870 | |
| B | THR1911 | |
| B | HIS1903 |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1ytw |
| Chain | Residue | Details |
| A | ARG1910 | |
| A | CYS1904 | |
| A | ASP1870 | |
| A | THR1911 |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1ytw |
| Chain | Residue | Details |
| B | ARG1910 | |
| B | CYS1904 | |
| B | ASP1870 | |
| B | THR1911 |
