2HFP
Crystal Structure of PPAR Gamma with N-sulfonyl-2-indole carboxamide ligands
Summary for 2HFP
Entry DOI | 10.2210/pdb2hfp/pdb |
Descriptor | Peroxisome proliferator-activated receptor gamma, SRC Peptide Fragment, 3-(4-METHOXYPHENYL)-N-(PHENYLSULFONYL)-1-[3-(TRIFLUOROMETHYL)BENZYL]-1H-INDOLE-2-CARBOXAMIDE, ... (4 entities in total) |
Functional Keywords | ppar ppargamma lbd, transcription |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: Q86U60 |
Total number of polymer chains | 2 |
Total formula weight | 36028.53 |
Authors | Pokross, M.E.,Evdokimov, A.G.,Walter, R.L.,Mekel, M.J.,Hopkins, C.R. (deposition date: 2006-06-25, release date: 2006-09-19, Last modification date: 2024-02-14) |
Primary citation | Hopkins, C.R.,O'neil, S.V.,Laufersweiler, M.C.,Wang, Y.,Pokross, M.,Mekel, M.,Evdokimov, A.,Walter, R.,Kontoyianni, M.,Petrey, M.E.,Sabatakos, G.,Roesgen, J.T.,Richardson, E.,Demuth Jr., T.P. Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-gamma binding agents with potential application to the treatment of osteoporosis. Bioorg.Med.Chem.Lett., 16:5659-5663, 2006 Cited by PubMed: 16919947DOI: 10.1016/j.bmcl.2006.08.003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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