2HFP

Crystal Structure of PPAR Gamma with N-sulfonyl-2-indole carboxamide ligands

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE NSI A 478

Chain	Residue
A	HOH56
A	ALA292
A	ILE326
A	LEU330
A	ILE341
A	SER342
A	NSI479
A	HOH128
A	GLU259
A	LYS265
A	HIS266
A	ILE281
A	GLY284
A	CYS285
A	ARG288

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site_id	AC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE NSI A 479

Chain	Residue
A	ALA278
A	CYS285
A	GLN286
A	HIS323
A	TYR327
A	PHE360
A	PHE363
A	LYS367
A	HIS449
A	LEU452
A	LEU453
A	LEU469
A	TYR473
A	NSI478

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	265
Details	Domain: {"description":"NR LBD","evidences":[{"source":"PROSITE-ProRule","id":"PRU01189","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	8
Details	Motif: {"description":"9aaTAD","evidences":[{"source":"PubMed","id":"30468856","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"9744270","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2PRG","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"36737649","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	4
Details	Motif: {"description":"LXXLL motif 4"}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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