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2HFP

Crystal Structure of PPAR Gamma with N-sulfonyl-2-indole carboxamide ligands

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0004879molecular_functionnuclear receptor activity
A0005634cellular_componentnucleus
A0006355biological_processregulation of DNA-templated transcription
Functional Information from PDB Data
site_idAC1
Number of Residues15
DetailsBINDING SITE FOR RESIDUE NSI A 478
ChainResidue
AHOH56
AALA292
AILE326
ALEU330
AILE341
ASER342
ANSI479
AHOH128
AGLU259
ALYS265
AHIS266
AILE281
AGLY284
ACYS285
AARG288

site_idAC2
Number of Residues14
DetailsBINDING SITE FOR RESIDUE NSI A 479
ChainResidue
AALA278
ACYS285
AGLN286
AHIS323
ATYR327
APHE360
APHE363
ALYS367
AHIS449
ALEU452
ALEU453
ALEU469
ATYR473
ANSI478

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues265
DetailsDomain: {"description":"NR LBD","evidences":[{"source":"PROSITE-ProRule","id":"PRU01189","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues8
DetailsMotif: {"description":"9aaTAD","evidences":[{"source":"PubMed","id":"30468856","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"9744270","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2PRG","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"36737649","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues4
DetailsMotif: {"description":"LXXLL motif 4"}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

243083

PDB entries from 2025-10-15

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