2HFP
Crystal Structure of PPAR Gamma with N-sulfonyl-2-indole carboxamide ligands
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Peroxisome proliferator-activated receptor gamma | polymer | 282 | 32467.6 | 1 | UniProt (Q86U60) Pfam (PF00104) UniProt (by SIFTS) (P37231) | Homo sapiens (human) | PPAR-gamma |
| 2 | B (B) | SRC Peptide Fragment | polymer | 21 | 2431.8 | 1 | UniProt (Q2T9G5) UniProt (by SIFTS) (Q15788) | ||
| 3 | C, D (A) | 3-(4-METHOXYPHENYL)-N-(PHENYLSULFONYL)-1-[3-(TRIFLUOROMETHYL)BENZYL]-1H-INDOLE-2-CARBOXAMIDE | non-polymer | 564.6 | 2 | Chemie (NSI) | |||
| 4 | E, F (A, B) | water | water | 18.0 | 122 | Chemie (HOH) |
Sequence modifications
A: 206 - 477 (UniProt: Q86U60)
| PDB | External Database | Details |
|---|---|---|
| Met 196 | - | cloning artifact |
| Ser 197 | - | cloning artifact |
| Tyr 198 | - | cloning artifact |
| Tyr 199 | - | cloning artifact |
| His 200 | - | cloning artifact |
| His 201 | - | cloning artifact |
| His 202 | - | cloning artifact |
| His 203 | - | cloning artifact |
| His 204 | - | cloning artifact |
| His 205 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 34899.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1129.2 | |
| All* | Total formula weight | 36028.5 |
