Author results

2J8A
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X-RAY STRUCTURE OF THE N-TERMINUS RRM DOMAIN OF SET1
Descriptor:HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-4 SPECIFIC
Authors:Tresaugues, L., Dehe, P.M., Guerois, R., Rodriguez-Gil, A., Varlet, I., Salah, P., Pamblanco, M., Luciano, P., Quevillon-Cheruel, S., Sollier, J., Leulliot, N., Couprie, J., Tordera, V., Zinn-Justin, S., Chavez, S., Van Tilbeurgh, H., Geli, V.
Deposit date:2006-10-24
Release date:2007-03-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:X-Ray Structure of the N-Terminus Rrm Domain of Set1
To be Published
3COU
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CRYSTAL STRUCTURE OF HUMAN NUDIX MOTIF 16 (NUDT16)
Descriptor:Nucleoside diphosphate-linked moiety X motif 16
Authors:Tresaugues, L., Moche, M., Arrowsmith, C.H., Berglund, H., Busam, R.D., Collins, R., Dahlgren, L.G., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Herman, M.D., Johansson, A., Johansson, I., Kallas, A., Karlberg, T., Kotenyova, T., Lehtio, L., Nilsson, M.E., Nyman, T., Persson, C., Sagemark, J., Schueler, H., Svensson, L., Thorsell, A.G., Van Den Berg, S., Welin, M., Weigelt, J., Wikstrom, M., Nordlund, P., Structural Genomics Consortium (SGC)
Deposit date:2008-03-29
Release date:2008-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of human Nudix motif 16 (NUDT16).
To be Published
3D3L
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THE 2.6 A CRYSTAL STRUCTURE OF THE LIPOXYGENASE DOMAIN OF HUMAN ARACHIDONATE 12-LIPOXYGENASE, 12S-TYPE (CASP TARGET)
Descriptor:Arachidonate 12-lipoxygenase, 12S-type, FE (III) ION
Authors:Tresaugues, L., Moche, M., Arrowsmith, C.H., Berglund, H., Busam, R.D., Collins, R., Dahlgren, L.G., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Herman, M.D., Johansson, A., Johansson, I., Kallas, A., Karlberg, T., Kotenyova, T., Lehtio, L., Nilsson, M.E., Nyman, T., Olesen, K., Persson, C., Sagemark, J., Schueler, H., Svensson, L., Thorsell, A.G., Van Den Berg, S., Welin, M., Weigelt, J., Wikstrom, M., Nordlund, P., Structural Genomics Consortium (SGC)
Deposit date:2008-05-12
Release date:2008-09-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of the lipoxygenase domain of human Arachidonate 12-lipoxygenase, 12S-type.
To be Published
3EQ5
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CRYSTAL STRUCTURE OF FRAGMENT 137 TO 238 OF THE HUMAN SKI-LIKE PROTEIN
Descriptor:Ski-like protein
Authors:Tresaugues, L., Wisniewska, M., Andersson, J., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Dahlgren, L.G., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, A., Johansson, I., Karlberg, T., Kotenyova, T., Lehtio, L., Moche, M., Nilsson, M.E., Nyman, T., Olesen, K., Persson, C., Sagemark, J., Schueler, H., Thorsell, A.G., Van Den Berg, S., Welin, M., Wikstrom, M., Weigelt, J., Nordlund, P., Structural Genomics Consortium (SGC)
Deposit date:2008-09-30
Release date:2009-01-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal structure of fragment 137 to 238 of the human Ski-like protein.
To be Published
3FXT
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CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF HUMAN NUDT6
Descriptor:Nucleoside diphosphate-linked moiety X motif 6, GLYCEROL
Authors:Tresaugues, L., Welin, M., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Dahlgren, L.G., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, A., Johansson, I., Karlberg, T., Kotenyova, T., Lehtio, L., Moche, M., Nilsson, M.E., Nyman, T., Persson, C., Sagemark, J., Schueler, H., Siponen, M.I., Thorsell, A.G., Van Den Berg, S., Weigelt, J., Wikstrom, M., Nordlund, P., Structural Genomics Consortium (SGC)
Deposit date:2009-01-21
Release date:2009-03-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the N-terminal domain of human NUDT6
To be Published
3GG6
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CRYSTAL STRUCTURE OF THE NUDIX DOMAIN OF HUMAN NUDT18
Descriptor:Nucleoside diphosphate-linked moiety X motif 18
Authors:Tresaugues, L., Siponen, M.I., Lehtio, L., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Dahlgren, L.G., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, A., Johansson, I., Karlberg, T., Kotenyova, T., Moche, M., Nilsson, M.E., Nyman, T., Persson, C., Sagemark, J., Schueler, H., Thorsell, A.G., Van Den Berg, S., Weigelt, J., Welin, M., Wisniewska, M., Nordlund, P., Structural Genomics Consortium (SGC)
Deposit date:2009-02-27
Release date:2009-03-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of the NUDIX domain of human NUDT18
To be Published
3H95
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CRYSTAL STRUCTURE OF THE NUDIX DOMAIN OF NUDT6
Descriptor:Nucleoside diphosphate-linked moiety X motif 6, CITRATE ANION, GLYCEROL
Authors:Tresaugues, L., Moche, M., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, A., Johansson, I., Karlberg, T., Kotyenova, T., Kotzch, A., Nielsen, T.K., Nyman, T., Persson, C., Sagemark, J., Schueler, H., Schutz, P., Siponen, M.I., Svensson, L., Thorsell, A.G., Van Den Berg, S., Weigelt, J., Welin, M., Wisniewska, M., Nordlund, P., Structural Genomics Consortium (SGC)
Deposit date:2009-04-30
Release date:2009-07-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of the NUDIX domain of NUDT6
To be Published
3HNG
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CRYSTAL STRUCTURE OF VEGFR1 IN COMPLEX WITH N-(4-CHLOROPHENYL)-2-((PYRIDIN-4-YLMETHYL)AMINO)BENZAMIDE
Descriptor:Vascular endothelial growth factor receptor 1, N-(4-chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide, CHLORIDE ION
Authors:Tresaugues, L., Roos, A., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, A., Johansson, I., Karlberg, T., Kotenyova, T., Moche, M., Nyman, T., Persson, C., Kragh-Nielsen, T., Kotzch, A., Sagemark, J., Schueler, H., Schutz, P., Siponen, M.I., Svensson, L., Thorsell, A.G., Van der Berg, S., Weigelt, J., Welin, M., Wisniewska, M., Nordlund, P., Structural Genomics Consortium (SGC)
Deposit date:2009-05-31
Release date:2009-06-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of VEGFR1 in complex with N-(4-Chlorophenyl)-2-((pyridin-4-ylmethyl)amino)benzamide
To be Published
2XSQ
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CRYSTAL STRUCTURE OF HUMAN NUDIX MOTIF 16 (NUDT16) IN COMPLEX WITH IMP AND MAGNESIUM
Descriptor:U8 SNORNA-DECAPPING ENZYME, INOSINIC ACID, MAGNESIUM ION, ...
Authors:Tresaugues, L., Welin, M., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, I., Karlberg, T., Kol, S., Kotenyova, T., Kouznetsova, E., Moche, M., Nyman, T., Persson, C., Schuler, H., Schutz, P., Siponen, M.I., Thorsell, A.G., van den Berg, S., Wahlberg, E., Weigelt, J., Nordlund, P.
Deposit date:2010-09-29
Release date:2010-11-17
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Structural Basis for the Specificity of Human Nudt16 and its Regulation by Inosine Monophosphate.
Plos One, 10, 2015
2XSW
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CRYSTAL STRUCTURE OF HUMAN INPP5E
Descriptor:72 KDA INOSITOL POLYPHOSPHATE 5-PHOSPHATASE, CHLORIDE ION, GLYCEROL
Authors:Tresaugues, L., Schutz, P., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, I., Karlberg, T., Kol, S., Kotenyova, T., Kouznetsova, E., Moche, M., Nyman, T., Persson, C., Schuler, H., Schutz, P., Siponen, M.I., Thorsell, A.G., Van Der Berg, S., Wahlberg, E., Weigelt, J., Welin, M., Nordlund, P.
Deposit date:2010-09-30
Release date:2010-11-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of Human Inpp5E
To be Published
2YBX
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CRYSTAL STRUCTURE OF HUMAN PHOSPHATIDYLINOSITOL-5-PHOSPHATE 4-KINASE TYPE-2 ALPHA
Descriptor:PHOSPHATIDYLINOSITOL-5-PHOSPHATE 4-KINASE TYPE-2 ALPHA, PHOSPHATE ION
Authors:Tresaugues, L., Moche, M., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Ekblad, T., Flodin, S., Graslund, S., Karlberg, T., Kotenyova, T., Kouznetsova, E., Nyman, T., Persson, C., Schuler, H., Siponen, M.I., Thorsell, A.G., Wahlberg, E., Weigelt, J., Nordlund, P.
Deposit date:2011-03-30
Release date:2012-01-25
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Crystal Structure of Human Phosphatidylinositol-5-Phosphate 4-Kinase Type-2 Alpha
To be Published
3KVH
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CRYSTAL STRUCTURE OF HUMAN PROTEIN SYNDESMOS (NUDT16-LIKE PROTEIN)
Descriptor:Protein syndesmos, GLYCEROL, CHLORIDE ION
Authors:Tresaugues, L., Siponen, M.I., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, A., Johansson, I., Kallas, A., Karlberg, T., Kotenyova, T., Kotzsch, A., Kraulis, P., Moche, M., Nielsen, T.K., Nyman, T., Persson, C., Roos, A.K., Schuler, H., Schutz, P., Thorsell, A.G., Van Den Berg, S., Weigelt, J., Welin, M., Wisniewska, M., Nordlund, P., Structural Genomics Consortium (SGC)
Deposit date:2009-11-30
Release date:2010-01-19
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of human protein syndesmos (NUDT16L1)
To be Published
3LS8
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CRYSTAL STRUCTURE OF HUMAN PIK3C3 IN COMPLEX WITH 3-[4-(4-MORPHOLINYL)THIENO[3,2-D]PYRIMIDIN-2-YL]-PHENOL
Descriptor:Phosphatidylinositol 3-kinase catalytic subunit type 3, 3-(4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)phenol, CHLORIDE ION, ...
Authors:Tresaugues, L., Welin, M., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, I., Karlberg, T., Kotenyova, T., Kraulis, P., Moche, M., Nyman, T., Persson, C., Schuler, H., Schutz, P., Siponen, M.I., Thorsell, A.G., Van den Berg, S., Wahlberg, E., Weigelt, J., Wisniewska, M., Nordlund, P., Structural Genomics Consortium (SGC)
Deposit date:2010-02-12
Release date:2010-03-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal structure of human PIK3C3 in complex with 3-[4-(4-Morpholinyl)thieno[3,2-d]pyrimidin-2-yl]-phenol
To be Published
3MCF
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CRYSTAL STRUCTURE OF HUMAN DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE 3-ALPHA
Descriptor:Diphosphoinositol polyphosphate phosphohydrolase 3-alpha, CITRATE ANION, GLYCEROL
Authors:Tresaugues, L., Welin, M., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, I., Karlberg, T., Kol, S., Kotenyova, T., Moche, M., Nyman, T., Persson, C., Schuler, H., Schutz, P., Siponen, M.I., Thorsell, A.G., van der Berg, S., Wahlberg, E., Weigelt, J., Wisniewska, M., Nordlund, P., Structural Genomics Consortium (SGC)
Deposit date:2010-03-29
Release date:2010-04-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of human diphosphoinositol polyphosphate phosphohydrolase 3-alpha
To be Published
3MTC
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CRYSTAL STRUCTURE OF INPP5B IN COMPLEX WITH PHOSPHATIDYLINOSITOL 4-PHOSPHATE
Descriptor:Type II inositol-1,4,5-trisphosphate 5-phosphatase, GLYCEROL, MAGNESIUM ION, ...
Authors:Tresaugues, L., Welin, M., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, I., Karlberg, T., Kol, S., Kotenyova, T., Moche, M., Nyman, T., Persson, C., Schuler, H., Schutz, P., Siponen, M.I., Thorsell, A.G., van der Berg, S., Wahlberg, E., Weigelt, J., Wisniewska, M., Nordlund, P., Structural Genomics Consortium (SGC)
Deposit date:2010-04-30
Release date:2010-06-30
Last modified:2014-05-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for phosphoinositide substrate recognition, catalysis, and membrane interactions in human inositol polyphosphate 5-phosphatases
Structure, 22, 2014
3N9U
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CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE 25 KDA SUBUNIT AND THE 59 KDA SUBUNIT (RRM DOMAIN) OF HUMAN CLEAVAGE FACTOR IM
Descriptor:Cleavage and polyadenylation specificity factor subunit 5, Cleavage and polyadenylation specificity factor subunit 7, GLYCEROL
Authors:Tresaugues, L., Welin, M., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, I., Karlberg, T., Kol, S., Kotenyova, T., Moche, M., Nielsen, T.N., Nyman, T., Persson, C., Schuler, H., Schutz, P., Siponen, M.I., Thorsell, A.G., van der Berg, S., Wahlberg, E., Weigelt, J., Wisniewska, M., Nordlund, P., Structural Genomics Consortium (SGC)
Deposit date:2010-05-31
Release date:2010-07-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Crystal Structure of the Complex between the 25 kDa Subunit and the 59 kDa Subunit (RRM domain) of Human Cleavage Factor Im
To be Published
3N9V
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CRYSTAL STRUCTURE OF INPP5B
Descriptor:Type II inositol-1,4,5-trisphosphate 5-phosphatase, MAGNESIUM ION, CALCIUM ION, ...
Authors:Tresaugues, L., Welin, M., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, I., Karlberg, T., Kol, S., Kotenyova, T., Moche, M., Nyman, T., Persson, C., Schuler, H., Schutz, P., Siponen, M.I., Thorsell, A.G., van der Berg, S., Wahlberg, E., Weigelt, J., Wisniewska, M., Nordlund, P., Structural Genomics Consortium (SGC)
Deposit date:2010-05-31
Release date:2010-07-28
Last modified:2014-05-28
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural basis for phosphoinositide substrate recognition, catalysis, and membrane interactions in human inositol polyphosphate 5-phosphatases
Structure, 22, 2014
3NR8
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CRYSTAL STRUCTURE OF HUMAN SHIP2
Descriptor:Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2, CHLORIDE ION
Authors:Tresaugues, L., Welin, M., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, I., Karlberg, T., Kol, S., Kotenyova, T., Kouznetsova, E., Moche, M., Nyman, T., Persson, C., Schuler, H., Schutz, P., Siponen, M.I., Thorsell, A.G., van der Berg, S., Wahlberg, E., Weigelt, J., Nordlund, P., Structural Genomics Consortium (SGC)
Deposit date:2010-06-30
Release date:2010-08-25
Last modified:2014-05-28
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for phosphoinositide substrate recognition, catalysis, and membrane interactions in human inositol polyphosphate 5-phosphatases
Structure, 22, 2014
3Q91
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CRYSTAL STRUCTURE OF HUMAN URIDINE DIPHOSPHATE GLUCOSE PYROPHOSPHATASE (NUDT14)
Descriptor:Uridine diphosphate glucose pyrophosphatase
Authors:Tresaugues, L., Siponen, M.I., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Ekblad, T., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, I., Karlberg, T., Kol, S., Kotenyova, T., Kouznetsova, E., Moche, M., Nyman, T., Persson, C., Schuler, H., Schutz, P., Thorsell, A.G., Van Der Berg, S., Wahlberg, E., Weigelt, J., Welin, M., Nordlund, P., Structural Genomics Consortium (SGC)
Deposit date:2011-01-07
Release date:2011-02-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structure of Human Uridine Diphosphate Glucose Pyrophosphatase (NUDT14)
To be Published
3Q93
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CRYSTAL STRUCTURE OF HUMAN 8-OXO-DGTPASE (MTH1)
Descriptor:7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION, IMIDAZOLE, ...
Authors:Tresaugues, L., Siponen, M.I., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Ekblad, T., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, I., Karlberg, T., Kol, S., Kotenyova, T., Kouznetsova, E., Moche, M., Nyman, T., Persson, C., Schuler, H., Schutz, P., Thorsell, A.G., Van Der Berg, S., Wahlberg, E., Weigelt, J., Welin, M., Nordlund, P., Structural Genomics Consortium (SGC)
Deposit date:2011-01-07
Release date:2011-03-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of Human 8-oxo-dGTPase (MTH1)
To be Published
3ZZW
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CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF ROR2
Descriptor:TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR2, CHLORIDE ION, SULFATE ION
Authors:Tresaugues, L., Moche, M., Arrowsmith, C.H., Berglund, H., Bountra, C., Edwards, A.M., Ekblad, T., Graslund, S., Karlberg, T., Nyman, T., Schuler, H., Thorsell, A.G., Weigelt, J., Nordlund, P., Structural Genomics Consortium (SGC)
Deposit date:2011-09-05
Release date:2011-09-14
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal Structure of the Kinase Domain of Ror2
To be Published
4CML
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CRYSTAL STRUCTURE OF INPP5B IN COMPLEX WITH PHOSPHATIDYLINOSITOL 3,4- BISPHOSPHATE
Descriptor:TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5- PHOSPHATASE, ISOFORM 2, 1,2-dioctanoyl phosphatidyl epi-inositol (3,4)-bisphosphate, ...
Authors:Tresaugues, L., Arrowsmith, C.H., Berglund, H., Bountra, C., Edwards, A.M., Ekblad, T., Flodin, S., Graslund, S., Karlberg, T., Moche, M., Nyman, T., Schuler, H., Silvander, C., Thorsell, A.G., Weigelt, J., Welin, M., Nordlund, P.
Deposit date:2014-01-16
Release date:2014-04-16
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Basis for Phosphoinositide Substrate Recognition, Catalysis, and Membrane Interactions in Human Inositol Polyphosphate 5-Phosphatases.
Structure, 22, 2014
4CMN
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CRYSTAL STRUCTURE OF OCRL IN COMPLEX WITH A PHOSPHATE ION
Descriptor:INOSITOL POLYPHOSPHATE 5-PHOSPHATASE OCRL-1, PHOSPHATE ION, MAGNESIUM ION, ...
Authors:Tresaugues, L., Moche, M., Arrowsmith, C.H., Berglund, H., Bountra, C., Edwards, A.M., Ekblad, T., Flodin, S., Graslund, S., Karlberg, T., Nyman, T., Schuler, H., Silvander, C., Thorsell, A.G., Weigelt, J., Welin, M., Nordlund, P.
Deposit date:2014-01-16
Release date:2014-04-16
Last modified:2014-05-21
Method:X-RAY DIFFRACTION (3.13 Å)
Cite:Structural Basis for Phosphoinositide Substrate Recognition, Catalysis, and Membrane Interactions in Human Inositol Polyphosphate 5-Phosphatases.
Structure, 22, 2014
2XS6
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CRYSTAL STRUCTURE OF THE RHOGAP DOMAIN OF HUMAN PIK3R2
Descriptor:PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA, CHLORIDE ION
Authors:Tresaugues, L., Welin, M., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, I., Karlberg, T., Kol, S., Kotenyova, T., Kouznetsova, E., Moche, M., Nyman, T., Persson, C., Schuler, H., Schutz, P., Siponen, M.I., Thorsell, A.G., van der Berg, S., Wahlberg, E., Weigelt, J., Nordlund, P.
Deposit date:2010-09-24
Release date:2010-11-17
Last modified:2016-04-06
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:The Structure and Catalytic Mechanism of Human Sphingomyelin Phosphodiesterase Like 3A - an Acid Sphingomyelinase Homolog with a Novel Nucleotide Hydrolase Activity.
FEBS J., 283, 2016
4A9C
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CRYSTAL STRUCTURE OF HUMAN SHIP2 IN COMPLEX WITH BIPHENYL 2,3',4,5',6- PENTAKISPHOSPHATE
Descriptor:PHOSPHATIDYLINOSITOL-3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2, BIPHENYL 2,3',4,5',6-PENTAKISPHOSPHATE
Authors:Tresaugues, L., Arrowsmith, C.H., Berglund, H., Bountra, C., Edwards, A.M., Ekblad, T., Graslund, S., Karlberg, T., Mills, S.J., Moche, M., Nyman, T., Persson, C., Potter, B.V.L., Schuler, H., Thorsell, A.G., Weigelt, J., Nordlund, P.
Deposit date:2011-11-25
Release date:2012-05-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A Synthetic Polyphosphoinositide Headgroup Surrogate in Complex with Ship2 Provides a Rationale for Drug Discovery.
Acs Chem.Biol., 7, 2012