3LS8

Crystal structure of human PIK3C3 in complex with 3-[4-(4-Morpholinyl)thieno[3,2-d]pyrimidin-2-yl]-phenol

Summary for 3LS8

• Entry DOI: 10.2210/pdb3ls8/pdb
• Related: 3IHY
• Descriptor: Phosphatidylinositol 3-kinase catalytic subunit type 3, 3-(4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)phenol, CHLORIDE ION, ... (5 entities in total)
• Functional Keywords: alpha/beta protein, pik3c3, phosphatidylinositol 3-kinase catalytic subunit type 3, compound 15e, structural genomics, sgc stockholm, structural genomics consortium, sgc, atp-binding, kinase, nucleotide-binding, phosphoprotein, transferase, inhibitor, phosphatidylinositol
• Biological source: Homo sapiens (human)
• Cellular location: Midbody: Q8NEB9
• Total number of polymer chains: 2
• Total formula weight: 141097.06

Authors

Tresaugues, L.,Welin, M.,Arrowsmith, C.H.,Berglund, H.,Bountra, C.,Collins, R.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Johansson, I.,Karlberg, T.,Kotenyova, T.,Kraulis, P.,Moche, M.,Nyman, T.,Persson, C.,Schuler, H.,Schutz, P.,Siponen, M.I.,Thorsell, A.G.,Van den Berg, S.,Wahlberg, E.,Weigelt, J.,Wisniewska, M.,Nordlund, P.,Structural Genomics Consortium (SGC) (deposition date: 2010-02-12, release date: 2010-03-23, Last modification date: 2023-09-06)

• Primary citation: Tresaugues, L.,Welin, M.,Arrowsmith, C.H.,Berglund, H.,Bountra, C.,Collins, R.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Johansson, I.,Karlberg, T.,Kotenyova, T.,Kraulis, P.,Moche, M.,Nyman, T.,Persson, C.,Schuler, H.,Schutz, P.,Siponen, M.I.,Thorsell, A.G.,Van den Berg, S.,Wahlberg, E.,Weigelt, J.,Wisniewska, M.,Nordlund, P.; Crystal structure of human PIK3C3 in complex with 3-[4-(4-Morpholinyl)thieno[3,2-d]pyrimidin-2-yl]-phenol; To be Published,

Experimental method

X-RAY DIFFRACTION (2.25 Å)