3LS8
Crystal structure of human PIK3C3 in complex with 3-[4-(4-Morpholinyl)thieno[3,2-d]pyrimidin-2-yl]-phenol
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Phosphatidylinositol 3-kinase catalytic subunit type 3 | polymer | 614 | 70118.2 | 2 | UniProt (Q8NEB9) Pfam (PF00613) Pfam (PF00454) | Homo sapiens (human) | PtdIns-3-kinase type 3, PI3-kinase type 3, PI3K type 3, Phosphoinositide-3-kinase class 3, Phosphatidylinositol 3-kinase p100 subunit |
| 2 | C, G (A, B) | 3-(4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)phenol | non-polymer | 313.4 | 2 | Chemie (AJZ) | |||
| 3 | D, E, H, I (A, B) | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
| 4 | F (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | J, K (A, B) | water | water | 18.0 | 260 | Chemie (HOH) |
Sequence modifications
A, B: 268 - 879 (UniProt: Q8NEB9)
| PDB | External Database | Details |
|---|---|---|
| Ser 266 | - | expression tag |
| Met 267 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 140236.4 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 860.7 | |
| All* | Total formula weight | 141097.1 |
