3D3L

The 2.6 A crystal structure of the lipoxygenase domain of human arachidonate 12-lipoxygenase, 12S-type

Summary for 3D3L

• Entry DOI: 10.2210/pdb3d3l/pdb
• Descriptor: Arachidonate 12-lipoxygenase, 12S-type, FE (III) ION (3 entities in total)
• Functional Keywords: alox12, iron-binding protein, arachidonate 12-lipoxygenase, 12-lox, platelet-type lipoxygenase 12, oxygenase, arachidonate, structural genomics, structural genomics consortium, sgc, cytoplasm, dioxygenase, leukotriene biosynthesis, metal-binding, oxidoreductase, polymorphism
• Biological source: Homo sapiens
• Cellular location: Cytoplasm: P18054
• Total number of polymer chains: 2
• Total formula weight: 122431.95

Authors

Tresaugues, L.,Moche, M.,Arrowsmith, C.H.,Berglund, H.,Busam, R.D.,Collins, R.,Dahlgren, L.G.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Herman, M.D.,Johansson, A.,Johansson, I.,Kallas, A.,Karlberg, T.,Kotenyova, T.,Lehtio, L.,Nilsson, M.E.,Nyman, T.,Olesen, K.,Persson, C.,Sagemark, J.,Schueler, H.,Svensson, L.,Thorsell, A.G.,Van Den Berg, S.,Welin, M.,Weigelt, J.,Wikstrom, M.,Nordlund, P.,Structural Genomics Consortium (SGC) (deposition date: 2008-05-12, release date: 2008-09-09, Last modification date: 2023-08-30)

• Primary citation: Tresaugues, L.,Moche, M.,Arrowsmith, C.H.,Berglund, H.,Busam, R.D.,Collins, R.,Dahlgren, L.G.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Herman, M.D.,Johansson, A.,Johansson, I.,Kallas, A.,Karlberg, T.,Kotenyova, T.,Lehtio, L.,Nilsson, M.E.,Nyman, T.,Olesen, K.,Persson, C.,Sagemark, J.,Schueler, H.,Svensson, L.,Thorsell, A.G.,Van Den Berg, S.,Welin, M.,Weigelt, J.,Wikstrom, M.,Nordlund, P.; Crystal structure of the lipoxygenase domain of human Arachidonate 12-lipoxygenase, 12S-type.; To be Published,

Experimental method

X-RAY DIFFRACTION (2.6 Å)