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3D3L

The 2.6 A crystal structure of the lipoxygenase domain of human arachidonate 12-lipoxygenase, 12S-type

Functional Information from GO Data
ChainGOidnamespacecontents
A0005506molecular_functioniron ion binding
A0016702molecular_functionoxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
A0034440biological_processlipid oxidation
A0046872molecular_functionmetal ion binding
B0005506molecular_functioniron ion binding
B0016702molecular_functionoxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
B0034440biological_processlipid oxidation
B0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE FE A 801
ChainResidue
AHIS360
AHIS365
AHIS540
AASN544
AHOH802

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE FE B 801
ChainResidue
BHIS360
BHIS365
BHIS540
BHOH802

Functional Information from PROSITE/UniProt
site_idPS00081
Number of Residues11
DetailsLIPOXYGENASE_2 Lipoxygenases iron-binding region signature 2. LHPIfKFLiPH
ChainResidueDetails
ALEU382-HIS392

site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. FTCTAQH
ChainResidueDetails
APHE534-HIS540

site_idPS00711
Number of Residues15
DetailsLIPOXYGENASE_1 Lipoxygenases iron-binding region signature 1. HEiqyHlLNTHLVaE
ChainResidueDetails
AHIS355-GLU369

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00726
ChainResidueDetails
ALEU172
BLEU172

Catalytic Information from CSA
site_idCSA1
Number of Residues1
DetailsAnnotated By Reference To The Literature 1lnh
ChainResidueDetails
AASN544

site_idCSA2
Number of Residues1
DetailsAnnotated By Reference To The Literature 1lnh
ChainResidueDetails
BASN544

226707

PDB entries from 2024-10-30

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