3D3L
The 2.6 A crystal structure of the lipoxygenase domain of human arachidonate 12-lipoxygenase, 12S-type
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Arachidonate 12-lipoxygenase, 12S-type | polymer | 541 | 61160.1 | 2 | UniProt (P18054) Pfam (PF00305) | Homo sapiens | 12-LOX, Platelet-type lipoxygenase 12 |
| 2 | C, D (A, B) | FE (III) ION | non-polymer | 55.8 | 2 | Chemie (FE) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 106 | Chemie (HOH) |
Sequence modifications
A, B: 172 - 663 (UniProt: P18054)
| PDB | External Database | Details |
|---|---|---|
| Met 155 | - | expression tag |
| His 156 | - | expression tag |
| His 157 | - | expression tag |
| His 158 | - | expression tag |
| His 159 | - | expression tag |
| His 160 | - | expression tag |
| His 161 | - | expression tag |
| Ser 162 | - | expression tag |
| Ser 163 | - | expression tag |
| Gly 164 | - | expression tag |
| Val 165 | - | expression tag |
| Asp 166 | - | expression tag |
| Leu 167 | - | expression tag |
| Gly 168 | - | expression tag |
| Thr 169 | - | expression tag |
| Glu 170 | - | expression tag |
| Asn 171 | - | expression tag |
| Arg 261 | Gln 261 | variant |
| Ser 663 | Ile 663 | engineered mutation |
| Asp 664 | - | expression tag |
| Ser 665 | - | expression tag |
| Lys 666 | - | expression tag |
| Gly 667 | - | expression tag |
| Gly 668 | - | expression tag |
| Tyr 669 | - | expression tag |
| Gly 670 | - | expression tag |
| Ser 671 | - | expression tag |
| Glu 672 | - | expression tag |
| Phe 673 | - | expression tag |
| Glu 674 | - | expression tag |
| Leu 675 | - | expression tag |
| Arg 676 | - | expression tag |
| Arg 677 | - | expression tag |
| Gln 678 | - | expression tag |
| Ala 679 | - | expression tag |
| Cys 680 | - | expression tag |
| Gly 681 | - | expression tag |
| Arg 682 | - | expression tag |
| Thr 683 | - | expression tag |
| Arg 684 | - | expression tag |
| Ala 685 | - | expression tag |
| Pro 686 | - | expression tag |
| Pro 687 | - | expression tag |
| Pro 688 | - | expression tag |
| Pro 689 | - | expression tag |
| Pro 690 | - | expression tag |
| Leu 691 | - | expression tag |
| Arg 692 | - | expression tag |
| Ser 693 | - | expression tag |
| Gly 694 | - | expression tag |
| Cys 695 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 122320.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 111.7 | |
| All* | Total formula weight | 122431.9 |
