3HNG

Crystal structure of VEGFR1 in complex with N-(4-Chlorophenyl)-2-((pyridin-4-ylmethyl)amino)benzamide

Summary for 3HNG

• Entry DOI: 10.2210/pdb3hng/pdb
• Descriptor: Vascular endothelial growth factor receptor 1, N-(4-chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: receptor tyrosine kinase, vegfr1, flt1, kinase domain, inhibitor, activation loop, vascular endothelial growth factor receptor, structural genomics, structural genomics consortium, sgc, sgc stockholm, angiogenesis, atp-binding, cell membrane, developmental protein, differentiation, disulfide bond, glycoprotein, immunoglobulin domain, kinase, membrane, nucleotide-binding, phosphoprotein, receptor, secreted, transferase, transmembrane, tyrosine-protein kinase
• Biological source: Homo sapiens (human)
• Cellular location: Isoform Flt1: Cell membrane; Single-pass type I membrane protein. Isoform sFlt1: Secreted: P17948
• Total number of polymer chains: 1
• Total formula weight: 41454.38

Authors

Tresaugues, L.,Roos, A.,Arrowsmith, C.H.,Berglund, H.,Bountra, C.,Collins, R.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Johansson, A.,Johansson, I.,Karlberg, T.,Kotenyova, T.,Moche, M.,Nyman, T.,Persson, C.,Kragh-Nielsen, T.,Kotzch, A.,Sagemark, J.,Schueler, H.,Schutz, P.,Siponen, M.I.,Svensson, L.,Thorsell, A.G.,Van der Berg, S.,Weigelt, J.,Welin, M.,Wisniewska, M.,Nordlund, P.,Structural Genomics Consortium (SGC) (deposition date: 2009-05-31, release date: 2009-06-30, Last modification date: 2023-11-01)

• Primary citation: Tresaugues, L.,Roos, A.,Arrowsmith, C.H.,Berglund, H.,Bountra, C.,Collins, R.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Johansson, A.,Johansson, I.,Karlberg, T.,Kotenyova, T.,Moche, M.,Nyman, T.,Persson, C.,Kragh-Nielsen, T.,Kotzch, A.,Sagemark, J.,Schueler, H.,Schutz, P.,Siponen, M.I.,Svensson, L.,Thorsell, A.G.,Van der Berg, S.,Weigelt, J.,Welin, M.,Wisniewska, M.,Nordlund, P.; Crystal structure of VEGFR1 in complex with N-(4-Chlorophenyl)-2-((pyridin-4-ylmethyl)amino)benzamide; To be Published,

Experimental method

X-RAY DIFFRACTION (2.7 Å)