4UXB

Human ARTD1 (PARP1) - Catalytic domain in complex with inhibitor PJ34

Summary for 4UXB

Entry DOI	10.2210/pdb4uxb/pdb
Descriptor	POLY ADP-RIBOSE POLYMERASE 1, N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE, SULFATE ION, ... (4 entities in total)
Functional Keywords	transferase, nad, adp-ribose, parp1, artd1, artd transferase domain, adp- ribosylation, transferase-transferase inhibitor complex
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Nucleus: P09874
Total number of polymer chains	2
Total formula weight	79460.89
Authors	Tresaugues, L.,Thorsell, A.G.,Karlberg, T.,Schuler, H. (deposition date: 2014-08-21, release date: 2015-09-02, Last modification date: 2024-01-10)
Primary citation	Thorsell, A.G.,Ekblad, T.,Karlberg, T.,Low, M.,Pinto, A.F.,Tresaugues, L.,Moche, M.,Cohen, M.S.,Schuler, H. Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors. J. Med. Chem., 60:1262-1271, 2017 Cited by PubMed: 28001384 DOI: 10.1021/acs.jmedchem.6b00990 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.22 Å)

Structure validation