8RXR

Crystal structure of VPS34 in complex with inhibitor SB02024

This is a non-PDB format compatible entry.

Summary for 8RXR

• Entry DOI: 10.2210/pdb8rxr/pdb
• Descriptor: Phosphatidylinositol 3-kinase catalytic subunit type 3, 4-[(3R)-3-methylmorpholin-4-yl]-2-[(2R)-2-(trifluoromethyl)piperidin-1-yl]-3H-pyridin-6-one, DI(HYDROXYETHYL)ETHER, ... (7 entities in total)
• Functional Keywords: inhibitor, complex, kinase, autophagy, drug discovery, signaling, signaling protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 138801.88

Authors

Tresaugues, L.,Yu, Y.,Bogdan, M.,Parpal, S.,Silvander, C.,Lindstrom, J.,Simeon, J.,Timson, M.J.,Al-Hashimi, H.,Smith, B.D.,Flynn, D.L.,Viklund, J.,Martinsson, J.,De Milito, A.,Andersson, M. (deposition date: 2024-02-07, release date: 2024-03-20, Last modification date: 2024-03-27)

• Primary citation: Yu, Y.,Bogdan, M.,Noman, M.Z.,Parpal, S.,Bartolini, E.,Van Moer, K.,Kleinendorst, S.C.,Bilgrav Saether, K.,Tresaugues, L.,Silvander, C.,Lindstrom, J.,Simeon, J.,Timson, M.J.,Al-Hashimi, H.,Smith, B.D.,Flynn, D.L.,Alexeyenko, A.,Viklund, J.,Andersson, M.,Martinsson, J.,Pokrovskaja Tamm, K.,De Milito, A.,Janji, B.; Combining VPS34 inhibitors with STING agonists enhances type I interferon signaling and anti-tumor efficacy.; Mol Oncol, 2024; PubMed: 38506049; DOI: 10.1002/1878-0261.13619

Experimental method

X-RAY DIFFRACTION (2.06 Å)