8RXR
Crystal structure of VPS34 in complex with inhibitor SB02024
This is a non-PDB format compatible entry.
Summary for 8RXR
Entry DOI | 10.2210/pdb8rxr/pdb |
Descriptor | Phosphatidylinositol 3-kinase catalytic subunit type 3, 4-[(3R)-3-methylmorpholin-4-yl]-2-[(2R)-2-(trifluoromethyl)piperidin-1-yl]-3H-pyridin-6-one, DI(HYDROXYETHYL)ETHER, ... (7 entities in total) |
Functional Keywords | inhibitor, complex, kinase, autophagy, drug discovery, signaling, signaling protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 138801.88 |
Authors | Tresaugues, L.,Yu, Y.,Bogdan, M.,Parpal, S.,Silvander, C.,Lindstrom, J.,Simeon, J.,Timson, M.J.,Al-Hashimi, H.,Smith, B.D.,Flynn, D.L.,Viklund, J.,Martinsson, J.,De Milito, A.,Andersson, M. (deposition date: 2024-02-07, release date: 2024-03-20, Last modification date: 2024-08-21) |
Primary citation | Yu, Y.,Bogdan, M.,Noman, M.Z.,Parpal, S.,Bartolini, E.,Van Moer, K.,Kleinendorst, S.C.,Bilgrav Saether, K.,Tresaugues, L.,Silvander, C.,Lindstrom, J.,Simeon, J.,Timson, M.J.,Al-Hashimi, H.,Smith, B.D.,Flynn, D.L.,Alexeyenko, A.,Viklund, J.,Andersson, M.,Martinsson, J.,Pokrovskaja Tamm, K.,De Milito, A.,Janji, B. Combining VPS34 inhibitors with STING agonists enhances type I interferon signaling and anti-tumor efficacy. Mol Oncol, 18:1904-1922, 2024 Cited by PubMed: 38506049DOI: 10.1002/1878-0261.13619 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.06 Å) |
Structure validation
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