8RXR
Crystal structure of VPS34 in complex with inhibitor SB02024
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Phosphatidylinositol 3-kinase catalytic subunit type 3 | polymer | 600 | 68556.3 | 2 | UniProt (Q8NEB9) Pfam (PF00613) Pfam (PF00454) | Homo sapiens (human) | PI3-kinase type 3,PI3K type 3,PtdIns-3-kinase type 3,Phosphatidylinositol 3-kinase p100 subunit,Phosphoinositide-3-kinase class 3,hVps34 |
| 2 | C, K (A, B) | 4-[(3R)-3-methylmorpholin-4-yl]-2-[(2R)-2-(trifluoromethyl)piperidin-1-yl]-3H-pyridin-6-one | non-polymer | 345.4 | 2 | Chemie (A1H4E) | |||
| 3 | D, I (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 2 | Chemie (PEG) | |||
| 4 | E (A) | IMIDAZOLE | non-polymer | 69.1 | 1 | Chemie (IMD) | |||
| 5 | F, G, H, L, M... (A, B) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 8 | Chemie (DMS) | |||
| 6 | J (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 7 | Q, R (A, B) | water | water | 18.0 | 590 | Chemie (HOH) |
Sequence modifications
A, B: 282 - 879 (UniProt: Q8NEB9)
| PDB | External Database | Details |
|---|---|---|
| Ser 280 | - | expression tag |
| Met 281 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 137112.7 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 1689.2 | |
| All* | Total formula weight | 138801.9 |
