4CML

Crystal Structure of INPP5B in complex with Phosphatidylinositol 3,4- bisphosphate

Summary for 4CML

• Entry DOI: 10.2210/pdb4cml/pdb
• Related: 4CMN
• Descriptor: TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5- PHOSPHATASE, ISOFORM 2, 1,2-dioctanoyl phosphatidyl epi-inositol (3,4)-bisphosphate, MAGNESIUM ION, ... (7 entities in total)
• Functional Keywords: hydrolase, sgc, signalling, structural genomics consortium stockholm, magnesium binding
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Cytoplasm, cytosol : P32019
• Total number of polymer chains: 1
• Total formula weight: 37195.57

Authors

Tresaugues, L.,Arrowsmith, C.H.,Berglund, H.,Bountra, C.,Edwards, A.M.,Ekblad, T.,Flodin, S.,Graslund, S.,Karlberg, T.,Moche, M.,Nyman, T.,Schuler, H.,Silvander, C.,Thorsell, A.G.,Weigelt, J.,Welin, M.,Nordlund, P. (deposition date: 2014-01-16, release date: 2014-04-16, Last modification date: 2023-12-20)

• Primary citation: Tresaugues, L.,Silvander, C.,Flodin, S.,Welin, M.,Nyman, T.,Graslund, S.,Hammarstrom, M.,Berglund, H.,Nordlund, P.; Structural Basis for Phosphoinositide Substrate Recognition, Catalysis, and Membrane Interactions in Human Inositol Polyphosphate 5-Phosphatases.; Structure, 22:744-, 2014; PubMed: 24704254; DOI: 10.1016/J.STR.2014.01.013

Experimental method

X-RAY DIFFRACTION (2.3 Å)