Author results

1MNM
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YEAST MATALPHA2/MCM1/DNA TERNARY TRANSCRIPTION COMPLEX CRYSTAL STRUCTURE
Descriptor:DNA (STE6 OPERATOR DNA), PROTEIN (MCM1 TRANSCRIPTIONAL REGULATOR), PROTEIN (MAT ALPHA-2 TRANSCRIPTIONAL REPRESSOR)
Authors:Tan, S., Richmond, T.J.
Deposit date:1997-11-03
Release date:1998-03-18
Last modified:2017-02-15
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal structure of the yeast MATalpha2/MCM1/DNA ternary complex.
Nature, 391, 1998
5WT9
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COMPLEX STRUCTURE OF PD-1 AND NIVOLUMAB-FAB
Descriptor:Heavy Chain of Nivolumab, Light Chain of Nivolumab, Programmed cell death protein 1, ...
Authors:Tan, S., Zhang, H., Chai, Y., Song, H., Tong, Z., Wang, Q., Qi, J., Wong, G., Zhu, X., Liu, W.J., Gao, S., Wang, Z., Shi, Y., Yang, F., Gao, G.F., Yan, J.
Deposit date:2016-12-10
Release date:2017-02-15
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (2.401 Å)
Cite:An unexpected N-terminal loop in PD-1 dominates binding by nivolumab.
Nat Commun, 8, 2017
5XJ4
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COMPLEX STRUCTURE OF DURVALUMAB-SCFV/PD-L1
Descriptor:Programmed cell death 1 ligand 1, durvalumab-VH, durvalumab-VL
Authors:Tan, S., Liu, K., Chai, Y., Gao, G.F., Qi, J.
Deposit date:2017-04-29
Release date:2018-04-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Distinct PD-L1 binding characteristics of therapeutic monoclonal antibody durvalumab
Protein Cell, 9, 2018
1YTF
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YEAST TFIIA/TBP/DNA COMPLEX
Descriptor:DNA (5'-D(*TP*GP*TP*AP*TP*GP*TP*AP*TP*AP*TP*AP*AP*AP*AP*C)-3'), DNA (5'-D(*GP*TP*TP*TP*TP*AP*TP*AP*TP*AP*CP*AP*TP*AP*CP*A)-3'), PROTEIN (TATA BINDING PROTEIN (TBP)), ...
Authors:Tan, S., Hunziker, Y., Sargent, D.F., Richmond, T.J.
Deposit date:1996-04-05
Release date:1996-06-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of a yeast TFIIA/TBP/DNA complex.
Nature, 381, 1996
5GRJ
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CRYSTAL STRUCTURE OF HUMAN PD-L1 WITH MONOCLONAL ANTIBODY AVELUMAB
Descriptor:avelumab H chain, avelumab L chain, Programmed cell death 1 ligand 1
Authors:Liu, K., Tan, S., Chai, Y., Chen, D., Song, H., Zhang, C.W.-H., Shi, Y., Liu, J., Tan, W., Lyu, J., Gao, S., Yan, J., Qi, J., Gao, G.F.
Deposit date:2016-08-11
Release date:2016-11-02
Last modified:2017-01-18
Method:X-RAY DIFFRACTION (3.206 Å)
Cite:Structural basis of anti-PD-L1 monoclonal antibody avelumab for tumor therapy.
Cell Res., 27, 2017
3RL1
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HIV RT DERIVED PEPTIDE COMPLEXED TO HLA-A*0301
Descriptor:HLA class I histocompatibility antigen, A-3 alpha chain, Beta-2-microglobulin, ...
Authors:Zhang, S., Liu, J., Cheng, H., Tan, S., Qi, J., Yan, J., Gao, G.F.
Deposit date:2011-04-19
Release date:2012-02-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis of cross-allele presentation by HLA-A*0301 and HLA-A*1101 revealed by two HIV-derived peptide complexes
Mol.Immunol., 49, 2011
3RL2
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HIV NEF DERIVED PEPTIDE NEF73 COMPLEXED TO HLA-A*0301
Descriptor:HLA class I histocompatibility antigen, A-3 alpha chain, Beta-2-microglobulin, ...
Authors:Zhang, S., Liu, J., Cheng, H., Tan, S., Qi, J., Yan, J., Gao, G.F.
Deposit date:2011-04-19
Release date:2012-02-29
Method:X-RAY DIFFRACTION (2.386 Å)
Cite:Structural basis of cross-allele presentation by HLA-A*0301 and HLA-A*1101 revealed by two HIV-derived peptide complexes
Mol.Immunol., 49, 2011
4F7M
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CRYSTAL STRUCTURE OF HLA-A*2402 COMPLEXED WITH A NEWLY IDENTIFIED PEPTIDE FROM 2009 H1N1 PA (649-658)
Descriptor:HLA class I histocompatibility antigen, A-24 alpha chain, Beta-2-microglobulin, ...
Authors:Liu, J., Zhang, S., Tan, S., Yi, Y., Wu, B., Zhu, F., Wang, H., Qi, J., George, F.G.
Deposit date:2012-05-16
Release date:2012-10-10
Last modified:2012-12-05
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Cross-Allele Cytotoxic T Lymphocyte Responses against 2009 Pandemic H1N1 Influenza A Virus among HLA-A24 and HLA-A3 Supertype-Positive Individuals.
J.Virol., 86, 2012
4F7P
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CRYSTAL STRUCTURE OF HLA-A*2402 COMPLEXED WITH A NEWLY IDENTIFIED PEPTIDE FROM 2009H1N1 PB1 (496-505)
Descriptor:HLA class I histocompatibility antigen, A-24 alpha chain, Beta-2-microglobulin, ...
Authors:Liu, J., Zhang, S., Tan, S., Yi, Y., Wu, B., Zhu, F., Wang, H., Qi, J., Gao, G.F.
Deposit date:2012-05-16
Release date:2012-10-10
Last modified:2012-12-05
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Cross-Allele Cytotoxic T Lymphocyte Responses against 2009 Pandemic H1N1 Influenza A Virus among HLA-A24 and HLA-A3 Supertype-Positive Individuals.
J.Virol., 86, 2012
4F7T
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CRYSTAL STRUCTURE OF HLA-A*2402 COMPLEXED WITH A NEWLY IDENTIFIED PEPTIDE FROM 2009 H1N1 PB1 (498-505)
Descriptor:HLA class I histocompatibility antigen, A-24 alpha chain, Beta-2-microglobulin, ...
Authors:Liu, J., Zhang, S., Tan, S., Yi, Y., Wu, B., Zhu, F., Wang, H., Qi, J., Gao, G.F.
Deposit date:2012-05-16
Release date:2012-10-10
Last modified:2012-12-05
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Cross-Allele Cytotoxic T Lymphocyte Responses against 2009 Pandemic H1N1 Influenza A Virus among HLA-A24 and HLA-A3 Supertype-Positive Individuals.
J.Virol., 86, 2012
4HWZ
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STRUCTURE OF HLA-A68 COMPLEXED WITH AN HIV DERIVED PEPTIDE
Descriptor:HLA class I histocompatibility antigen, A-68 alpha chain, Beta-2-microglobulin, ...
Authors:Niu, L., Cheng, H., Zhang, S., Tan, S., Zhang, Y., Qi, J., Liu, J., Gao, G.F.
Deposit date:2012-11-09
Release date:2013-10-16
Method:X-RAY DIFFRACTION (2.397 Å)
Cite:Structural basis for the differential classification of HLA-A*6802 and HLA-A*6801 into the A2 and A3 supertypes
Mol.Immunol., 55, 2013
4HX1
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STRUCTURE OF HLA-A68 COMPLEXED WITH A TUMOR ANTIGEN DERIVED PEPTIDE
Descriptor:MHC class I antigen, Beta-2-microglobulin, 9-mer peptide from Tyrosinase-related protein-2, ...
Authors:Niu, L., Cheng, H., Zhang, S., Tan, S., Zhang, Y., Qi, J., Liu, J., Gao, G.F.
Deposit date:2012-11-09
Release date:2013-10-02
Method:X-RAY DIFFRACTION (1.802 Å)
Cite:Structural basis for the differential classification of HLA-A*6802 and HLA-A*6801 into the A2 and A3 supertypes
Mol.Immunol., 55, 2013
4I48
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STRUCTURE OF HLA-A68 COMPLEXED WITH AN HIV ENV DERIVED PEPTIDE
Descriptor:HLA class I histocompatibility antigen, A-68 alpha chain, Beta-2-microglobulin, ...
Authors:Niu, L., Cheng, H., Zhang, S., Tan, S., Zhang, Y., Qi, J., Liu, J., Gao, G.F.
Deposit date:2012-11-27
Release date:2013-10-02
Method:X-RAY DIFFRACTION (2.799 Å)
Cite:Structural basis for the differential classification of HLA-A*6802 and HLA-A*6801 into the A2 and A3 supertypes
Mol.Immunol., 55, 2013
4MJ5
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CRYSTAL STRUCTURE OF HLA-A*1101 IN COMPLEX WITH H1-22, AN INFLUENZA A(H1N1) VIRUS EPITOPE
Descriptor:HLA class I histocompatibility antigen, A-11 alpha chain, Beta-2-microglobulin, ...
Authors:Liu, J., Tan, S., Zhao, M., Qi, J., Gao, G.F.
Deposit date:2013-09-03
Release date:2014-10-08
Last modified:2016-12-07
Method:X-RAY DIFFRACTION (2.401 Å)
Cite:Cross-Immunities against Avian Influenza H7N9 Virus in the Healthy Population Affected by Antigenicity-Dependent Substitutions.
J.INFECT.DIS., 2016
4MJ6
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CRYSTAL STRUCTURE OF HLA-A*1101 IN COMPLEX WITH H7-22, AN INFLUENZA A(H7N9) VIRUS EPITOPE
Descriptor:HLA class I histocompatibility antigen, A-11 alpha chain, Beta-2-microglobulin, ...
Authors:Liu, J., Tan, S., Zhao, M., Qi, J., Gao, G.F.
Deposit date:2013-09-03
Release date:2014-10-08
Last modified:2016-12-07
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:Cross-Immunities against Avian Influenza H7N9 Virus in the Healthy Population Affected by Antigenicity-Dependent Substitutions.
J.INFECT.DIS., 2016
6A3W
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COMPLEX STRUCTURE OF 4-1BB AND UTOMILUMAB
Descriptor:utomilumab VH, utomilumab VL, Tumor necrosis factor receptor superfamily member 9, ...
Authors:Li, Y., Tan, S., Zhang, C., Chai, Y., Qi, J., Tien, P., Gao, S., Gao, G.F.
Deposit date:2018-06-17
Release date:2018-10-10
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Limited Cross-Linking of 4-1BB by 4-1BB Ligand and the Agonist Monoclonal Antibody Utomilumab.
Cell Rep, 25, 2018
6CW2
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CRYSTAL STRUCTURE OF A YEAST SAGA TRANSCRIPTIONAL COACTIVATOR ADA2/GCN5 HAT SUBCOMPLEX, CRYSTAL FORM 1
Descriptor:Histone acetyltransferase GCN5, Transcriptional adapter 2, antibody heavy chain, ...
Authors:Sun, J., Paduch, M., Kim, S.A., Kramer, R.M., Barrios, A.F., Lu, V., Luke, J., Usatyuk, S., Kossiakoff, A.A., Tan, S.
Deposit date:2018-03-29
Release date:2018-09-19
Last modified:2018-10-10
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Structural basis for activation of SAGA histone acetyltransferase Gcn5 by partner subunit Ada2.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6CW3
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CRYSTAL STRUCTURE OF A YEAST SAGA TRANSCRIPTIONAL COACTIVATOR ADA2/GCN5 HAT SUBCOMPLEX, CRYSTAL FORM 2
Descriptor:antibody heavy chain, antibody light chain, Histone acetyltransferase GCN5, ...
Authors:Sun, J., Paduch, M., Kim, S.A., Kramer, R.M., Barrios, A.F., Lu, V., Luke, J., Usatyuk, S., Kossiakoff, A.A., Tan, S.
Deposit date:2018-03-29
Release date:2018-09-19
Last modified:2018-10-10
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Structural basis for activation of SAGA histone acetyltransferase Gcn5 by partner subunit Ada2.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6ISA
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MCD226
Descriptor:CD226 antigen
Authors:Wang, H., Qi, J., Zhang, S., Li, Y., Tan, S., Gao, G.F.
Deposit date:2018-11-16
Release date:2018-12-26
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Binding mode of the side-by-side two-IgV molecule CD226/DNAM-1 to its ligand CD155/Necl-5.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6ISB
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CRYSTAL STRUCTURE OF HUMAN CD226
Descriptor:CD226 antigen
Authors:Wang, H., Qi, J., Zhang, S., Li, Y., Tan, S., Gao, G.F.
Deposit date:2018-11-16
Release date:2018-12-26
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Binding mode of the side-by-side two-IgV molecule CD226/DNAM-1 to its ligand CD155/Necl-5.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6ISC
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COMPLEX STRUCTURE OF MCD226-ECTO AND HCD155-D1
Descriptor:CD226 antigen, Poliovirus receptor, N-ACETYL-D-GLUCOSAMINE
Authors:Wang, H., Qi, J., Zhang, S., Li, Y., Tan, S., Gao, G.F.
Deposit date:2018-11-16
Release date:2018-12-26
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Binding mode of the side-by-side two-IgV molecule CD226/DNAM-1 to its ligand CD155/Necl-5.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6JBT
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COMPLEX STRUCTURE OF TORIPALIMAB-FAB AND PD-1
Descriptor:Programmed cell death protein 1, Heavy chain, Light chain, ...
Authors:Guo, L., Tan, S., Chai, Y., Qi, J., Gao, G.F., Yan, J.
Deposit date:2019-01-26
Release date:2019-06-19
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:Glycosylation-independent binding of monoclonal antibody toripalimab to FG loop of PD-1 for tumor immune checkpoint therapy.
Mabs, 11, 2019
1F3U
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CRYSTAL STRUCTURE OF THE RAP30/74 INTERACTION DOMAINS OF HUMAN TFIIF
Descriptor:TRANSCRIPTION INITIATION FACTOR IIF, BETA SUBUNIT, ALPHA SUBUNIT
Authors:Gaiser, F., Tan, S., Richmond, T.J.
Deposit date:2000-06-06
Release date:2000-10-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Novel dimerization fold of RAP30/RAP74 in human TFIIF at 1.7 A resolution.
J.Mol.Biol., 302, 2000
1NH2
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CRYSTAL STRUCTURE OF A YEAST TFIIA/TBP/DNA COMPLEX
Descriptor:5'-D(*TP*GP*TP*AP*(5IU)P*GP*TP*AP*TP*AP*(5IU)P*AP*AP*AP*AP*C)-3', 5'-D(*GP*TP*TP*TP*TP*AP*TP*AP*TP*AP*CP*AP*TP*AP*CP*A)-3', Transcription initiation factor TFIID, ...
Authors:Bleichenbacher, M., Tan, S., Richmond, T.J.
Deposit date:2002-12-18
Release date:2003-10-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Novel interactions between the components of human and yeast TFIIA/TBP/DNA complexes.
J.Mol.Biol., 332, 2003
1NVP
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HUMAN TFIIA/TBP/DNA COMPLEX
Descriptor:5'-D(*GP*GP*GP*GP*GP*GP*GP*CP*TP*AP*TP*AP*AP*AP*AP*GP*G)-3', 5'-D(*CP*CP*TP*TP*TP*TP*AP*TP*AP*GP*CP*CP*CP*CP*CP*CP*C)-3', TATA box binding protein, ...
Authors:Bleichenbacher, M., Tan, S., Richmond, T.J.
Deposit date:2003-02-04
Release date:2003-10-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Novel interactions between the components of human and yeast TFIIA/TBP/DNA complexes.
J.Mol.Biol., 332, 2003
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