8HIT

Crystal structure of anti-CTLA-4 humanized IgG1 MAb--JS007 in complex with human CTLA-4

Summary for 8HIT

• Entry DOI: 10.2210/pdb8hit/pdb
• Descriptor: JS007-VH, JS007-VL, Cytotoxic T-lymphocyte protein 4 (3 entities in total)
• Functional Keywords: complex, anti-body, scfv, immune system
• Biological source: Mus musculus; More
• Total number of polymer chains: 3
• Total formula weight: 37671.14

Authors

Tan, S.,Shi, Y.,Wang, Q.,Gao, G.F.,Guan, J.,Chai, Y.,Qi, J. (deposition date: 2022-11-21, release date: 2023-02-01)

• Primary citation: Guan, J.,Liu, H.,Chai, Y.,Yu, J.,Yao, J.,Wang, J.,Pan, Z.,Zhang, J.,Zhou, Y.,Liu, H.,Yao, S.,Qi, J.,Feng, H.,Gao, G.F.,Wang, Q.,Shi, Y.,Tan, S.; Characterization of the high-affinity anti-CTLA-4 monoclonal antibody JS007 for immune checkpoint therapy of cancer.; Mabs, 15:2153409-2153409, 2023; PubMed: 36511654; DOI: 10.1080/19420862.2022.2153409

Experimental method

X-RAY DIFFRACTION (3.2 Å)