Author results

1A4J
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DIELS ALDER CATALYTIC ANTIBODY GERMLINE PRECURSOR
Descriptor:IMMUNOGLOBULIN, DIELS ALDER CATALYTIC ANTIBODY (LIGHT CHAIN), DIELS ALDER CATALYTIC ANTIBODY (HEAVY CHAIN)
Authors:Spiller, B.W., Romesburg, F.E., Schultz, P.G., Stevens, R.C.
Deposit date:1998-01-30
Release date:1998-05-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Immunological origins of binding and catalysis in a Diels-Alderase antibody.
Science, 279, 1998
1A4K
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DIELS ALDER CATALYTIC ANTIBODY WITH TRANSITION STATE ANALOGUE
Descriptor:ANTIBODY FAB, CADMIUM ION, [4-(4-ACETYLAMINO-PHENYL)-3,5-DIOXO-4-AZA-TRICYCLO[5.2.2.0 2,6]UNDEC-1-YLCARBAMOYLOXY]-ACETIC ACID
Authors:Spiller, B.W., Romesburg, F.E., Schultz, P.G., Stevens, R.C.
Deposit date:1998-01-30
Release date:1998-05-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Immunological origins of binding and catalysis in a Diels-Alderase antibody.
Science, 279, 1998
1ACM
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ARGININE 54 IN THE ACTIVE SITE OF ESCHERICHIA COLI ASPARTATE TRANSCARBAMOYLASE IS CRITICAL FOR CATALYSIS: A SITE-SPECIFIC MUTAGENESIS, NMR AND X-RAY CRYSTALLOGRAPHY STUDY
Descriptor:ASPARTATE CARBAMOYLTRANSFERASE, CATALYTIC CHAIN, ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN, ...
Authors:Stevens, R.C., Kantrowitz, E.R., Lipscomb, W.N.
Deposit date:1992-07-08
Release date:1992-07-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Arginine 54 in the active site of Escherichia coli aspartate transcarbamoylase is critical for catalysis: a site-specific mutagenesis, NMR, and X-ray crystallographic study.
Protein Sci., 1, 1992
1AJ7
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IMMUNOGLOBULIN 48G7 GERMLINE FAB ANTIBODY COMPLEXED WITH HAPTEN 5-(PARA-NITROPHENYL PHOSPHONATE)-PENTANOIC ACID. AFFINITY MATURATION OF AN ESTEROLYTIC ANTIBODY
Descriptor:IMMUNOGLOBULIN 48G7 FAB (LIGHT CHAIN), IMMUNOGLOBULIN 48G7 FAB (HEAVY CHAIN), 5-(PARA-NITROPHENYL PHOSPHONATE)-PENTANOIC ACID
Authors:Wedemayer, G.J., Wang, L.H., Patten, P.A., Schultz, P.G., Stevens, R.C.
Deposit date:1997-05-15
Release date:1997-11-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural insights into the evolution of an antibody combining site.
Science, 276, 1997
1AT1
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CRYSTAL STRUCTURES OF PHOSPHONOACETAMIDE LIGATED T AND PHOSPHONOACETAMIDE AND MALONATE LIGATED R STATES OF ASPARTATE CARBAMOYLTRANSFERASE AT 2.8-ANGSTROMS RESOLUTION AND NEUTRAL P*H
Descriptor:ASPARTATE CARBAMOYLTRANSFERASE, CATALYTIC CHAIN, ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN, ...
Authors:Gouaux, J.E., Lipscomb, W.N.
Deposit date:1989-09-22
Release date:1990-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of phosphonoacetamide ligated T and phosphonoacetamide and malonate ligated R states of aspartate carbamoyltransferase at 2.8-A resolution and neutral pH.
Biochemistry, 29, 1990
1AXS
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MATURE OXY-COPE CATALYTIC ANTIBODY WITH HAPTEN
Descriptor:OXY-COPE CATALYTIC ANTIBODY, CADMIUM ION, (1S,2S,5S)2-(4-GLUTARIDYLBENZYL)-5-PHENYL-1-CYCLOHEXANOL
Authors:Mundorff, E.C., Ulrich, H.D., Stevens, R.C.
Deposit date:1997-10-20
Release date:1998-02-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The interplay between binding energy and catalysis in the evolution of a catalytic antibody.
Nature, 389, 1997
1C7I
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THERMOPHYLIC PNB ESTERASE
Descriptor:PROTEIN (PARA-NITROBENZYL ESTERASE), CALCIUM ION
Authors:Spiller, B., Gershenson, A., Arnold, F., Stevens, R.
Deposit date:2000-02-21
Release date:2000-03-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A structural view of evolutionary divergence.
Proc.Natl.Acad.Sci.USA, 96, 1999
1C7J
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PNB ESTERASE 56C8
Descriptor:PROTEIN (PARA-NITROBENZYL ESTERASE), SULFATE ION, POTASSIUM ION
Authors:Spiller, B., Gershenson, A., Arnold, F., Stevens, R.C.
Deposit date:2000-02-21
Release date:2000-03-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:A structural view of evolutionary divergence.
Proc.Natl.Acad.Sci.USA, 96, 1999
1D5B
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UNLIGANDED MATURE OXY-COPE CATALYTIC ANTIBODY
Descriptor:chimeric OXY-COPE catalytic ANTIBODY AZ-28 (light chain), chimeric OXY-COPE catalytic ANTIBODY AZ-28 (HEAVY chain), CADMIUM ION
Authors:Mundorff, E.C., Hanson, M.A., Schultz, P.G., Stevens, R.C.
Deposit date:1999-10-06
Release date:2000-02-09
Last modified:2017-06-21
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Conformational effects in biological catalysis: an antibody-catalyzed oxy-cope rearrangement.
Biochemistry, 39, 2000
1D5I
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UNLIGANDED GERMLINE PRECURSOR OF AN OXY-COPE CATALYTIC ANTIBODY
Descriptor:CHIMERIC GERMLINE PRECURSOR OF OXY-COPE CATALYTIC ANTIBODY AZ-28 (LIGHT CHAIN), CHIMERIC GERMLINE PRECURSOR OF OXY-COPE CATALYTIC ANTIBODY AZ-28 (HEAVY CHAIN), CADMIUM ION
Authors:Mundorff, E.C., Hanson, M.A., Schultz, P.G., Stevens, R.C.
Deposit date:1999-10-07
Release date:2000-02-09
Last modified:2017-06-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Conformational effects in biological catalysis: an antibody-catalyzed oxy-cope rearrangement.
Biochemistry, 39, 2000
1D6V
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CONFORMATION EFFECTS IN BIOLOGICAL CATALYSIS INTRODUCED BY OXY-COPE ANTIBODY MATURATION
Descriptor:CHIMERIC GERMLINE PRECURSOR OF OXY-COPE CATALYTIC ANTIBODY AZ-28 (LIGHT CHAIN), CHIMERIC GERMLINE PRECURSOR OF OXY-COPE CATALYTIC ANTIBODY AZ-28 (HEAVY CHAIN), CADMIUM ION, ...
Authors:Mundorff, E.C., Hanson, M.A., Schultz, P.G., Stevens, R.C.
Deposit date:1999-10-15
Release date:2000-02-09
Last modified:2017-06-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Conformational effects in biological catalysis: an antibody-catalyzed oxy-cope rearrangement.
Biochemistry, 39, 2000
1DMW
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CRYSTAL STRUCTURE OF DOUBLE TRUNCATED HUMAN PHENYLALANINE HYDROXYLASE WITH BOUND 7,8-DIHYDRO-L-BIOPTERIN
Descriptor:PHENYLALANINE HYDROXYLASE, FE (III) ION, 7,8-DIHYDROBIOPTERIN
Authors:Erlandsen, H., Stevens, R.C., Flatmark, T.
Deposit date:1999-12-15
Release date:2000-03-24
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure and site-specific mutagenesis of pterin-bound human phenylalanine hydroxylase.
Biochemistry, 39, 2000
1E74
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NMR SOLUTION STRUCTURE OF ALPHA-CONOTOXIN IM1 POINT MUTATION VARIANT R11E
Descriptor:ALPHA-CONOTOXIN IM1(R11E)
Authors:Rogers, J.P., Luginbuhl, P., Pemberton, K., Harty, P., Wemmer, D.E., Stevens, R.C.
Deposit date:2000-08-24
Release date:2000-12-27
Last modified:2017-06-14
Method:SOLUTION NMR
Cite:Structure-Activity Relationships in a Peptidic Alpha7 Nicotinic Acetylcholine Receptor Antagonist
J.Mol.Biol., 304, 2000
1E75
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NMR SOLUTION STRUCTURE OF ALPHA-CONOTOXIN IM1 POINT MUTATION VARIANT R7L
Descriptor:ALPHA-CONOTOXIN IM1(R7L)
Authors:Rogers, J.P., Luginbuhl, P., Pemberton, K., Harty, P., Wemmer, D.E., Stevens, R.C.
Deposit date:2000-08-24
Release date:2000-12-27
Last modified:2017-06-14
Method:SOLUTION NMR
Cite:Structure-Activity Relationships in a Peptidic Alpha7 Nicotinic Acetylcholine Receptor Antagonist
J.Mol.Biol., 304, 2000
1E76
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NMR SOLUTION STRUCTURE OF ALPHA-CONOTOXIN IM1 POINT MUTATION VARIANT D5N
Descriptor:ALPHA-CONOTOXIN IM1(D5N)
Authors:Rogers, J.P., Luginbuhl, P., Pemberton, K., Harty, P., Wemmer, D.E., Stevens, R.C.
Deposit date:2000-08-24
Release date:2000-12-27
Last modified:2017-06-14
Method:SOLUTION NMR
Cite:Structure-Activity Relationships in a Peptidic Alpha7 Nicotinic Acetylcholine Receptor Antagonist
J.Mol.Biol., 304, 2000
1EZZ
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CRYSTAL STRUCTURE OF E. COLI ASPARTATE TRANSCARBAMOYLASE P268A MUTANT IN THE T-STATE
Descriptor:ASPARTATE CARBAMOYLTRANSFERASE CATALYTIC CHAIN, ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN, ZINC ION
Authors:Jin, L., Stec, B., Kantrowitz, E.R.
Deposit date:2000-05-12
Release date:2000-11-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A cis-proline to alanine mutant of E. coli aspartate transcarbamoylase: kinetic studies and three-dimensional crystal structures.
Biochemistry, 39, 2000
1F82
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BOTULINUM NEUROTOXIN TYPE B CATALYTIC DOMAIN
Descriptor:BOTULINUM NEUROTOXIN TYPE B, ZINC ION
Authors:Hanson, M.A., Stevens, R.C.
Deposit date:2000-06-28
Release date:2000-08-16
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Cocrystal structure of synaptobrevin-II bound to botulinum neurotoxin type B at 2.0 A resolution.
Nat.Struct.Biol., 7, 2000
1FL3
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CRYSTAL STRUCTURE OF THE BLUE FLUORESCENT ANTIBODY (19G2) IN COMPLEX WITH STILBENE HAPTEN AT 277K
Descriptor:BLUE FLUORESCENT ANTIBODY (19G2)-HEAVY CHAIN, BLUE FLUORESCENT ANTIBODY (19G2)-LIGHT CHAIN, 4-(4-STYRYL-PHENYLCARBAMOYL)-BUTYRIC ACID
Authors:Stevens, R.C., Beuscher IV, A.E.
Deposit date:2000-08-11
Release date:2000-11-01
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Blue-fluorescent antibodies.
Science, 290, 2000
1FL5
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THE UNLIGANDED GERMLINE PRECURSOR TO THE SULFIDE OXIDASE CATALYTIC ANTIBODY 28B4.
Descriptor:ANTIBODY GERMLINE PRECURSOR TO ANTIBODY 28B4, SULFATE ION
Authors:Yin, J., Mundorff, E.C., Yang, P.L., Wendt, K.U., Hanway, D., Stevens, R.C., Schultz, P.G.
Deposit date:2000-08-11
Release date:2001-11-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A comparative analysis of the immunological evolution of antibody 28B4.
Biochemistry, 40, 2001
1FL6
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THE HAPTEN COMPLEXED GERMLINE PRECURSOR TO SULFIDE OXIDASE CATALYTIC ANTIBODY 28B4
Descriptor:ANTIBODY GERMLINE PRECURSOR TO 28B4, 1-[N-4'-NITROBENZYL-N-4'-CARBOXYBUTYLAMINO]METHYLPHOSPHONIC ACID
Authors:Yin, J., Mundorff, E.C., Yang, P.L., Wendt, K.U., Hanway, D., Stevens, R.C., Schultz, P.G.
Deposit date:2000-08-11
Release date:2001-11-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A comparative analysis of the immunological evolution of antibody 28B4.
Biochemistry, 40, 2001
1G2G
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MINIMAL CONFORMATION OF THE ALPHA-CONOTOXIN IMI FOR THE ALPHA7 NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR RECOGNITION
Descriptor:ALPHA-CONOTOXIN IMI
Authors:Lamthanh, H., Jegou-Matheron, C., Servent, D., Menez, A., Lancelin, J.M.
Deposit date:2000-10-19
Release date:2000-11-08
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Minimal conformation of the alpha-conotoxin ImI for the alpha7 neuronal nicotinic acetylcholine receptor recognition: correlated CD, NMR and binding studies.
FEBS Lett., 454, 1999
1GAF
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48G7 HYBRIDOMA LINE FAB COMPLEXED WITH HAPTEN 5-(PARA-NITROPHENYL PHOSPHONATE)-PENTANOIC ACID
Descriptor:CHIMERIC 48G7 FAB, 5-(PARA-NITROPHENYL PHOSPHONATE)-PENTANOIC ACID
Authors:Wedemayer, G.J., Patten, P.A., Stevens, R.C., Schultz, P.G.
Deposit date:1996-02-06
Release date:1996-07-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The immunological evolution of catalysis.
Science, 271, 1996
1HKL
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FREE AND LIGANDED FORM OF AN ESTEROLYTIC CATALYTIC ANTIBODY
Descriptor:48G7 FAB
Authors:Wedemayer, G.J., Wang, L.H., Patten, P.A., Schultz, P.G., Stevens, R.C.
Deposit date:1996-12-20
Release date:1997-03-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Crystal structures of the free and liganded form of an esterolytic catalytic antibody.
J.Mol.Biol., 268, 1997
1HTZ
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CRYSTAL STRUCTURE OF TEM52 BETA-LACTAMASE
Descriptor:BETA-LACTAMASE MUTANT TEM52
Authors:Stevens, R.C., Orencia, M.C.
Deposit date:2001-01-03
Release date:2001-03-21
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Predicting the emergence of antibiotic resistance by directed evolution and structural analysis.
Nat.Struct.Biol., 8, 2001
1I5O
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CRYSTAL STRUCTURE OF MUTANT R105A OF E. COLI ASPARTATE TRANSCARBAMOYLASE
Descriptor:ASPARTATE TRANSCARBAMOYLASE CATALYTIC CHAIN, ASPARTATE TRANSCARBAMOYLASE REGULATORY CHAIN, ZINC ION, ...
Authors:Macol, C.P., Tsuruta, H., Stec, B., Kantrowitz, E.R.
Deposit date:2001-02-28
Release date:2001-05-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Direct structural evidence for a concerted allosteric transition in Escherichia coli aspartate transcarbamoylase.
Nat.Struct.Biol., 8, 2001