8WKZ

Crystal structure of the Melanocortin-4 Receptor (MC4R) in complex with S31

Summary for 8WKZ

Entry DOI	10.2210/pdb8wkz/pdb
Descriptor	Melanocortin receptor 4, [N-(3-{bis[2-(pyridin-2-yl-kappaN)ethyl]amino-kappaN}propyl)-5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide](azido)(hydroxy)copper, CALCIUM ION, ... (5 entities in total)
Functional Keywords	ca++ cofactor, gpcr, pgs fusion, membrane protein, lcp
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	62844.16
Authors	Gimenez, L.E.,Martin, C.,Yu, J.,Hollanders, C.,Hernandez, C.,Dahir, N.S.,Wu, Y.,Yao, D.,Han, G.W.,Wu, L.,Poorten, O.V.,Lamouroux, A.,Mannes, M.,Tourwe, D.,Zhao, S.,Stevens, R.C.,Cone, R.D.,Ballet, S. (deposition date: 2023-09-28, release date: 2024-08-07)
Primary citation	Gimenez, L.E.,Martin, C.,Yu, J.,Hollanders, C.,Hernandez, C.C.,Wu, Y.,Yao, D.,Han, G.W.,Dahir, N.S.,Wu, L.,Van der Poorten, O.,Lamouroux, A.,Mannes, M.,Zhao, S.,Tourwe, D.,Stevens, R.C.,Cone, R.D.,Ballet, S. Novel Cocrystal Structures of Peptide Antagonists Bound to the Human Melanocortin Receptor 4 Unveil Unexplored Grounds for Structure-Based Drug Design. J.Med.Chem., 67:2690-2711, 2024 Cited by PubMed: 38345933 DOI: 10.1021/acs.jmedchem.3c01822 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.3 Å)

Structure validation