6W25

Crystal structure of the Melanocortin-4 Receptor (MC4R) in complex with SHU9119

Summary for 6W25

Entry DOI	10.2210/pdb6w25/pdb
Descriptor	Melanocortin receptor 4,GlgA glycogen synthase,Melanocortin receptor 4, SHU9119, CALCIUM ION, ... (5 entities in total)
Functional Keywords	melanocortin-4 receptor, ca++ cofactor, shu9119, gpcr, pgs fusion, membrane protein, lcp
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	63575.38
Authors	Yu, J.,Gimenez, L.E.,Hernandez, C.C.,Wu, Y.,Wein, A.H.,Han, G.W.,McClary, K.,Mittal, S.R.,Burdsall, K.,Stauch, B.,Wu, L.,Stevens, S.N.,Peisley, A.,Williams, S.Y.,Chen, V.,Millhauser, G.L.,Zhao, S.,Cone, R.D.,Stevens, R.C. (deposition date: 2020-03-04, release date: 2020-04-29, Last modification date: 2023-11-15)
Primary citation	Yu, J.,Gimenez, L.E.,Hernandez, C.C.,Wu, Y.,Wein, A.H.,Han, G.W.,McClary, K.,Mittal, S.R.,Burdsall, K.,Stauch, B.,Wu, L.,Stevens, S.N.,Peisley, A.,Williams, S.Y.,Chen, V.,Millhauser, G.L.,Zhao, S.,Cone, R.D.,Stevens, R.C. Determination of the melanocortin-4 receptor structure identifies Ca2+as a cofactor for ligand binding. Science, 368:428-433, 2020 Cited by PubMed: 32327598 DOI: 10.1126/science.aaz8995 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.75 Å)

Structure validation