Author results

2KDI
  • Download 2kdi
  • View 2kdi
Molmil generated image of 2kdi
SOLUTION STRUCTURE OF A UBIQUITIN/UIM FUSION PROTEIN
Descriptor:Ubiquitin, Vacuolar protein sorting-associated protein 27 fusion protein
Authors:Sgourakis, N.G., Patel, M.M., Garcia, A.E., Makhatadze, G.I., McCallum, S.A.
Deposit date:2009-01-09
Release date:2010-02-09
Last modified:2020-02-19
Method:SOLUTION NMR
Cite:Conformational Dynamics and Structural Plasticity Play Critical Roles in the Ubiquitin Recognition of a UIM Domain.
J.Mol.Biol., 396, 2010
2MIZ
  • Download 2miz
  • View 2miz
Molmil generated image of 2miz
STRUCTURE OF THE M04/GP34 MOUSE CYTOMEGALOVIRUS IMMUNOEVASIN CORE DOMAIN
Descriptor:m04 immunoevasin
Authors:Sgourakis, N.G., Natarajan, K., Margulies, D.H., Bax, A.
Deposit date:2013-12-21
Release date:2014-07-16
Last modified:2014-10-22
Method:SOLUTION NMR
Cite:The Structure of Mouse Cytomegalovirus m04 Protein Obtained from Sparse NMR Data Reveals a Conserved Fold of the m02-m06 Viral Immune Modulator Family.
Structure, 22, 2014
2MPZ
  • Download 2mpz
  • View 2mpz
Molmil generated image of 2mpz
ATOMIC MODEL OF THE ABETA D23N "IOWA" MUTANT USING SOLID-STATE NMR, EM AND ROSETTA MODELING
Descriptor:Amyloid beta A4 protein
Authors:Sgourakis, N.G., Qiang, W.
Deposit date:2014-06-10
Release date:2015-04-22
Method:SOLID-STATE NMR
Cite:Modeling an in-register, parallel "iowa" a beta fibril structure using solid-state NMR data from labeled samples with rosetta.
Structure, 23, 2015
3J1V
  • Download 3j1v
  • View 3j1v
Molmil generated image of 3j1v
A REFINED MODEL OF THE PROTOTYPICAL SALMONELLA TYPHIMURIUM T3SS BASAL BODY REVEALS THE MOLECULAR BASIS FOR ITS ASSEMBLY
Descriptor:Protein InvG
Authors:Sgourakis, N.G., Bergeron, J.R.C., Strynadka, N.J.C., Baker, D.
Deposit date:2012-07-08
Release date:2013-05-22
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (11.7 Å)
Cite:A Refined Model of the Prototypical Salmonella SPI-1 T3SS Basal Body Reveals the Molecular Basis for Its Assembly.
Plos Pathog., 9, 2013
3J1W
  • Download 3j1w
  • View 3j1w
Molmil generated image of 3j1w
A REFINED MODEL OF THE PROTOTYPICAL SALMONELLA TYPHIMURIUM T3SS BASAL BODY REVEALS THE MOLECULAR BASIS FOR ITS ASSEMBLY
Descriptor:Protein PrgH
Authors:Sgourakis, N.G., Worrall, L.J., Strynadka, N.C.J., Baker, D.
Deposit date:2012-07-10
Release date:2013-05-22
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (11.7 Å)
Cite:A Refined Model of the Prototypical Salmonella SPI-1 T3SS Basal Body Reveals the Molecular Basis for Its Assembly.
Plos Pathog., 9, 2013
3J1X
  • Download 3j1x
  • View 3j1x
Molmil generated image of 3j1x
A REFINED MODEL OF THE PROTOTYPICAL SALMONELLA TYPHIMURIUM T3SS BASAL BODY REVEALS THE MOLECULAR BASIS FOR ITS ASSEMBLY
Descriptor:Protein PrgH
Authors:Sgourakis, N.G., Bergeron, J.R.C., Worrall, L.J., Strynadka, N.C.J., Baker, D.
Deposit date:2012-07-10
Release date:2013-05-22
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (11.7 Å)
Cite:A Refined Model of the Prototypical Salmonella SPI-1 T3SS Basal Body Reveals the Molecular Basis for Its Assembly.
Plos Pathog., 9, 2013
2LPZ
  • Download 2lpz
  • View 2lpz
Molmil generated image of 2lpz
ATOMIC MODEL OF THE TYPE-III SECRETION SYSTEM NEEDLE
Descriptor:Protein prgI
Authors:Loquet, A., Sgourakis, N.G., Gupta, R., Giller, K., Riedel, D., Goosmann, C., Griesinger, C., Kolbe, M.G., Baker, D., Becker, S., Lange, A.
Deposit date:2012-02-21
Release date:2012-05-16
Last modified:2012-06-27
Method:SOLID-STATE NMR
Cite:Atomic model of the type III secretion system needle.
Nature, 486, 2012
2M89
  • Download 2m89
  • View 2m89
Molmil generated image of 2m89
SOLUTION STRUCTURE OF THE AHA1 DIMER FROM COLWELLIA PSYCHRERYTHRAEA
Descriptor:Aha1 domain protein
Authors:Rossi, P., Sgourakis, N.G., Shi, L., Liu, G., Barbieri, C.M., Lee, H., Grant, T.D., Luft, J.R., Xiao, R., Acton, T.B., Montelione, G.T., Snell, E.H., Baker, D., Lange, O.A., Northeast Structural Genomics Consortium (NESG)
Deposit date:2013-05-09
Release date:2013-09-04
Last modified:2016-04-27
Method:SOLUTION NMR, SOLUTION SCATTERING
Cite:A hybrid NMR/SAXS-based approach for discriminating oligomeric protein interfaces using Rosetta.
Proteins, 83, 2015
2MJZ
  • Download 2mjz
  • View 2mjz
Molmil generated image of 2mjz
CAPSID MODEL OF M13 BACTERIOPHAGE VIRUS FROM MAGIC-ANGLE SPINNING NMR AND ROSETTA MODELING
Descriptor:Capsid protein G8P
Authors:Morag, O., Sgourakis, N.G., Baker, D., Goldbourt, A.
Deposit date:2014-01-22
Release date:2015-01-07
Last modified:2015-02-11
Method:SOLID-STATE NMR
Cite:The NMR-Rosetta capsid model of M13 bacteriophage reveals a quadrupled hydrophobic packing epitope.
Proc.Natl.Acad.Sci.USA, 112, 2015
2MME
  • Download 2mme
  • View 2mme
Molmil generated image of 2mme
HYBRID STRUCTURE OF THE SHIGELLA FLEXNERI MXIH TYPE THREE SECRETION SYSTEM NEEDLE
Descriptor:MxiH
Authors:Demers, J.P., Habenstein, B., Loquet, A., Vasa, S.K., Becker, S., Baker, D., Lange, A., Sgourakis, N.G.
Deposit date:2014-03-14
Release date:2014-10-08
Last modified:2020-02-05
Method:SOLID-STATE NMR (7.7 Å), ELECTRON MICROSCOPY
Cite:High-resolution structure of the Shigella type-III secretion needle by solid-state NMR and cryo-electron microscopy.
Nat Commun, 5, 2014
2MV0
  • Download 2mv0
  • View 2mv0
Molmil generated image of 2mv0
SOLUTION NMR STRUCTURE OF MALTOSE-BINDING PROTEIN FROM ESCHERICHIA COLI, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET ER690
Descriptor:Maltose-binding periplasmic protein
Authors:Rossi, P., Lange, O.F., Sgourakis, N.G., Song, Y., Lee, H., Aramini, J.M., Ertekin, A., Xiao, R., Acton, T.B., Baker, D., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2014-09-18
Release date:2014-12-10
Last modified:2015-07-01
Method:SOLUTION NMR
Cite:Determination of solution structures of proteins up to 40 kDa using CS-Rosetta with sparse NMR data from deuterated samples.
Proc.Natl.Acad.Sci.USA, 109, 2012
5TXS
  • Download 5txs
  • View 5txs
Molmil generated image of 5txs
CRYSTAL STRUCTURE OF AN ANAPLASTIC LYMPHOMA KINASE-DERIVED NEUROBLASTOMA TUMOR ANTIGEN BOUND TO THE HUMAN MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I MOLECULE HLA-B*1501
Descriptor:HLA class I histocompatibility antigen, B-15 alpha chain, Beta-2-microglobulin, ...
Authors:Toor, J., Rao, A.A., Salama, S., Tripathi, S., Haussler, D., Sgourakis, N.G.
Deposit date:2016-11-17
Release date:2017-11-29
Last modified:2018-03-21
Method:X-RAY DIFFRACTION (1.697 Å)
Cite:A Recurrent Mutation in Anaplastic Lymphoma Kinase with Distinct Neoepitope Conformations.
Front Immunol, 9, 2018
5VZ5
  • Download 5vz5
  • View 5vz5
Molmil generated image of 5vz5
CRYSTAL STRUCTURE OF AN ANAPLASTIC LYMPHOMA KINASE-DERIVED NEUROBLASTOMA TUMOR ANTIGEN BOUND TO THE HUMAN MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I MOLECULE HLA-B*1501
Descriptor:HLA class I histocompatibility antigen, B-15 alpha chain, Beta-2-microglobulin, ...
Authors:Toor, J., Rao, A.A., Salama, S., Tripathi, S., Haussler, D., Sgourakis, N.G.
Deposit date:2017-05-26
Release date:2018-03-21
Method:X-RAY DIFFRACTION (2.5901 Å)
Cite:A Recurrent Mutation in Anaplastic Lymphoma Kinase with Distinct Neoepitope Conformations.
Front Immunol, 9, 2018
5WOT
  • Download 5wot
  • View 5wot
Molmil generated image of 5wot
NMR SOLUTION STRUCTURE OF A-LYTIC PROTEASE USING TWO 4D-SPECTRA
Descriptor:Alpha-lytic protease
Authors:Evangelidis, T., Nerli, S., Sgourakis, N.G., Tripsianes, K.
Deposit date:2017-08-03
Release date:2018-02-07
Last modified:2019-12-11
Method:SOLUTION NMR
Cite:Automated NMR resonance assignments and structure determination using a minimal set of 4D spectra.
Nat Commun, 9, 2018
5WOX
  • Download 5wox
  • View 5wox
Molmil generated image of 5wox
NMR SOLUTION STRUCTURE OF KANY PROTEIN (MS6282) USING TWO 4D-SPECTRA
Descriptor:Uncharacterized protein
Authors:Evangelidis, T., Nerli, S., Sgourakis, N.G., Tripsianes, K.
Deposit date:2017-08-03
Release date:2018-02-07
Method:SOLUTION NMR
Cite:Automated NMR resonance assignments and structure determination using a minimal set of 4D spectra.
Nat Commun, 9, 2018
5WOY
  • Download 5woy
  • View 5woy
Molmil generated image of 5woy
NMR SOLUTION STRUCTURE OF ENZYME I (NEIT) PROTEIN USING TWO 4D-SPECTRA
Descriptor:Phosphoenolpyruvate-protein phosphotransferase
Authors:Evangelidis, T., Nerli, S., Sgourakis, N.G., Tripsianes, K.
Deposit date:2017-08-03
Release date:2018-02-07
Method:SOLUTION NMR
Cite:Automated NMR resonance assignments and structure determination using a minimal set of 4D spectra.
Nat Commun, 9, 2018
5WOZ
  • Download 5woz
  • View 5woz
Molmil generated image of 5woz
NMR SOLUTION STRUCTURE OF RTT103 (RTT) PROTEIN USING TWO 4D-SPECTRA
Descriptor:Regulator of Ty1 transposition protein 103
Authors:Evangelidis, T., Nerli, S., Sgourakis, N.G., Tripsianes, K.
Deposit date:2017-08-03
Release date:2018-02-07
Method:SOLUTION NMR
Cite:Automated NMR resonance assignments and structure determination using a minimal set of 4D spectra.
Nat Commun, 9, 2018
6AT9
  • Download 6at9
  • View 6at9
Molmil generated image of 6at9
CRYSTAL STRUCTURE OF AN ANAPLASTIC LYMPHOMA KINASE-DERIVED NEUROBLASTOMA TUMOR ANTIGEN BOUND TO THE HUMAN MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I MOLECULE HLA-A*0101
Descriptor:HLA class I histocompatibility antigen, A-1 alpha chain, Beta-2-microglobulin, ...
Authors:Toor, J., Rao, A.A., Salama, S., Tripathi, S., Haussler, D., Sgourakis, N.G.
Deposit date:2017-08-28
Release date:2018-03-21
Method:X-RAY DIFFRACTION (2.9503 Å)
Cite:A Recurrent Mutation in Anaplastic Lymphoma Kinase with Distinct Neoepitope Conformations.
Front Immunol, 9, 2018
6DMP
  • Download 6dmp
  • View 6dmp
Molmil generated image of 6dmp
DE NOVO DESIGN OF A PROTEIN HETERODIMER WITH SPECIFICITY MEDIATED BY HYDROGEN BOND NETWORKS
Descriptor:Designed orthogonal protein DHD13_XAAA_A, Designed orthogonal protein DHD13_XAAA_B
Authors:Chen, Z., Flores-Solis, D., Sgourakis, N.G., Baker, D.
Deposit date:2018-06-05
Release date:2018-12-19
Last modified:2019-11-20
Method:SOLUTION NMR
Cite:Programmable design of orthogonal protein heterodimers.
Nature, 565, 2019
6MPP
  • Download 6mpp
  • View 6mpp
Molmil generated image of 6mpp
MHC-I COMPLEX WITH NRAS Q16K MUTATION DETERMINED BY NMR
Descriptor:HLA class I histocompatibility antigen, A-1 alpha chain, NRAS Q16K peptide, ...
Authors:Flores-Solis, D., McShan, A.C., Sgourakis, N.G.
Deposit date:2018-10-08
Release date:2019-10-16
Last modified:2019-12-18
Method:SOLUTION NMR
Cite:MHC-I complex determined by NMR
To Be Published
6NAN
  • Download 6nan
  • View 6nan
Molmil generated image of 6nan
NMR STRUCTURE DETERMINATION OF IXOLARIS AND FACTOR X INTERACTION REVEALS A NONCANONICAL MECHANISM OF KUNITZ INHIBITION
Descriptor:Ixolaris
Authors:De Paula, V.S., Sgourakis, N.G., Francischetti, I.M.B., Almeida, F.C.L., Monteiro, R.Q., Valente, A.P.
Deposit date:2018-12-06
Release date:2019-06-12
Last modified:2019-09-04
Method:SOLUTION NMR
Cite:NMR structure determination of Ixolaris and factor X(a) interaction reveals a noncanonical mechanism of Kunitz inhibition.
Blood, 134, 2019
6NPR
  • Download 6npr
  • View 6npr
Molmil generated image of 6npr
CRYSTAL STRUCTURE OF H-2DD WITH C84-C139 DISULFIDE IN COMPLEX WITH GP120 DERIVED PEPTIDE P18-I10
Descriptor:H-2 class I histocompatibility antigen, D-D alpha chain, Beta-2-microglobulin, ...
Authors:Toor, J., McShan, A.C., Tripathi, S.M., Sgourakis, N.G.
Deposit date:2019-01-18
Release date:2020-01-22
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Molecular determinants of chaperone interactions on MHC-I for folding and antigen repertoire selection.
Proc.Natl.Acad.Sci.USA, 116, 2019
6OSW
  • Download 6osw
  • View 6osw
Molmil generated image of 6osw
AN ORDER-TO-DISORDER STRUCTURAL SWITCH ACTIVATES THE FOXM1 TRANSCRIPTION FACTOR
Descriptor:Forkhead box M1
Authors:Marceau, A.H., Rubin, S.M., Nerli, S., McShane, A.C., Sgourakis, N.G.
Deposit date:2019-05-02
Release date:2019-05-29
Last modified:2019-12-04
Method:SOLUTION NMR
Cite:An order-to-disorder structural switch activates the FoxM1 transcription factor.
Elife, 8, 2019
6B9K
  • Download 6b9k
  • View 6b9k
Molmil generated image of 6b9k
SOLUTION NMR STRUCTURE OF UNBOUND P18-I10
Descriptor:ARG-GLY-PRO-GLY-ARG-ALA-PHE-VAL-THR-ILE
Authors:Flores-Solis, D., McShan, A., Sgourakis, N.
Deposit date:2017-10-10
Release date:2018-07-25
Last modified:2019-04-17
Method:SOLUTION NMR
Cite:Peptide exchange on MHC-I by TAPBPR is driven by a negative allostery release cycle.
Nat. Chem. Biol., 14, 2018
6E5C
  • Download 6e5c
  • View 6e5c
Molmil generated image of 6e5c
SOLUTION NMR STRUCTURE OF A DE NOVO DESIGNED DOUBLE-STRANDED BETA-HELIX
Descriptor:De novo beta protein
Authors:Marcos, E., Chidyausiku, T.M., McShan, A., Evangelidis, T., Nerli, S., Sgourakis, N., Tripsianes, K., Baker, D.
Deposit date:2018-07-19
Release date:2018-11-07
Last modified:2018-11-14
Method:SOLUTION NMR
Cite:De novo design of a non-local beta-sheet protein with high stability and accuracy.
Nat. Struct. Mol. Biol., 25, 2018
<123>