8EK5

Engineered scFv 10LH bound to PHOX2B/HLA-A24:02

Summary for 8EK5

Entry DOI	10.2210/pdb8ek5/pdb
Descriptor	MHC class I antigen, Beta-2-microglobulin, Paired mesoderm homeobox protein 2B peptide, ... (7 entities in total)
Functional Keywords	neuroblastoma, phox2b, antitumor protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	95135.66
Authors	Garfinkle, S.E.,Florio, T.J.,Sgourakis, N.G. (deposition date: 2022-09-20, release date: 2023-12-06, Last modification date: 2023-12-13)
Primary citation	Sun, Y.,Florio, T.J.,Gupta, S.,Young, M.C.,Marshall, Q.F.,Garfinkle, S.E.,Papadaki, G.F.,Truong, H.V.,Mycek, E.,Li, P.,Farrel, A.,Church, N.L.,Jabar, S.,Beasley, M.D.,Kiefel, B.R.,Yarmarkovich, M.,Mallik, L.,Maris, J.M.,Sgourakis, N.G. Structural principles of peptide-centric chimeric antigen receptor recognition guide therapeutic expansion. Sci Immunol, 8:eadj5792-eadj5792, 2023 Cited by PubMed: 38039376 DOI: 10.1126/sciimmunol.adj5792 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.11 Å)

Structure validation